11:00 - 12:45 
    Registration, Lunch and Refreshments
    Princes Suite Foyer (Registration) & Princes Suite 2 (Lunch, refreshments & exhibition)
    12:45 - 13:00 
    Welcome & Introduction
    Princes Suite 1
    Chair: Peter McCormick (Liverpool, UK)
    Mon 09 13:00
    Appetite and Metabolism
    Lecture 1 - Nutritional regulation of gut hormone secretion through GPCRs
    Cambridge, United Kingdom
    Mon 09 13:30
    Appetite and Metabolism
    Lecture 2 - Subcellular architecture of glucagon receptor family signalling
    London, UK
    Mon 09 14:00
    OC1
    Oral Presentations 1
    Profiling GIPR signalling mechanisms underlying lipid metabolism rewiring in adipocytes
    London, UK
    Mon 09 14:15
    OC2
    Oral Presentations 1
    Two Succinate GPCR Pathways: Muscle Stem-Cell Sensing and Hypoxia-Induced Epithelial Signalling
    Copenhagen, Denmark
    14:30 - 14:45 
    Coffee Break, exhibition
    Princes Suite 2
    Mon 09 14:45
    Genetics
    Lecture 3 - GLP1 receptor variants and their role in metabolic disease
    Paris, France
    Mon 09 15:15
    Genetics
    Lecture 4 - Mapping expression of metabolically relevant GPCRs in the human brain
    Cambridge, UK
    Mon 09 15:45
    OC3
    Oral Presentations 2
    Circadian rhythm disruption reduces GLP1 and GIP agonist efficacy in pancreatic beta cells
    Oxford, UK
    Mon 09 16:00
    OC4
    Oral Presentations 2
    SSTR2 Receptor States and Recycling Dynamics Shape the Apparent Affinity of 177Lu-DOTATATE
    Uppsala, Sweden
    16:15 - 16:30 
    Coffee Break, exhibition
    Princes Suite 2
    Mon 09 16:30
    Keynote
    Signalling at the nanoscale: spatiotemporal organisation of the cAMP/PKA pathway
    UK
    17:15 - 19:00 
    Networking Drinks & Posters
    Princes Suite 2

    08:00 - 09:00 
    Morning Coffee and refreshments, exhibition
    Princes Suite 2
    Tue 10 09:00
    Drug Discovery
    Lecture 5 - De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
    Denmark
    Tue 10 09:30
    Drug Discovery
    Lecture 6 - More than a gut feeling: amylin, the next wave of obesity therapeutics.
    Indianapolis , USA
    Tue 10 10:00
    Drug Discovery
    Lecture 7 - Three Names: CRN00808, paltusotine, Palsonify
    USA
    10:30 - 10:45 
    Coffee Break, exhibition
    Princes Suite 2
    Tue 10 10:45
    Reproductive
    Lecture 8 - RFamide prolactin-releasing peptide analogue reduces body weight through a mechanism distinct from GLP1RA
    Manchester, UK
    Tue 10 11:15
    Reproductive
    Lecture 9 - Uncovering the molecular control of gonadotrophin hormone receptor actions in reproductive health and ageing
    London, UK
    Tue 10 11:45
    OC5
    Oral Presentations 3
    A GRK-Biased β₂-Adrenergic Receptor Agonist Induces Coordinated Fat Loss and Muscle Gain via Pathway-Selective Signaling
    Solna, Sweden
    Tue 10 12:00
    OC6
    Oral Presentations 3
    Ligand-PTH1R-βarrestin-complex stability dictates compartmentalized signaling
    Boston, MA, USA
    12:15 - 13:00 
    Lunch, exhibition
    Princes Suite 2
    Tue 10 13:00
    Endocrine
    Lecture 10 - From Orphan to Opportunity: Characterising the physiology and pharmacology of GPR75
    Aberdeen, Scotland
    Tue 10 13:30
    Endocrine
    Lecture 11 - Targeting the PTH-1R
    USA
    Tue 10 14:00
    OC7
    Oral Presentations 4
    In vivo role of β-arrestin 2 and GLP-1R and GIPR biased signalling in α-cells
    London, UK
    Tue 10 14:15
    OC8
    Oral Presentations 4
    Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism.
    Bath, UK
    14:30 - 14:45 
    Coffee Break, exhibition
    Princes Suite 2
    14:45 - 15:15 
    Panel Discussion
    Our final session brings a selection of our speakers together for an in‑depth closing panel, offering a fast‑paced overview of the key themes explored across the two‑day programme. This concluding discussion will highlight major insights, emerging trends, and shared challenges raised throughout the event.
    Princes Suite 1
    15:15 - 15:30 
    Poster Awards and Closing remarks from the Founding Group
    Princes Suite 1
Manuela Zaccolo
UK
Mon 09 16:30
Keynote
Signalling at the nanoscale: spatiotemporal organisation of the cAMP/PKA pathway
UK
Stephen Betz
USA
Tue 10 10:00
Drug Discovery
Lecture 7 - Three Names: CRN00808, paltusotine, Palsonify
USA
Hamza Bokhari
Solna, Sweden
Tue 10 11:45
OC5
Oral Presentations 3
A GRK-Biased β₂-Adrenergic Receptor Agonist Induces Coordinated Fat Loss and Muscle Gain via Pathway-Selective Signaling
Solna, Sweden
Sina Bondza
Uppsala, Sweden
Mon 09 16:00
OC4
Oral Presentations 2
SSTR2 Receptor States and Recycling Dynamics Shape the Apparent Affinity of 177Lu-DOTATATE
Uppsala, Sweden
Daniel A. Briere
Indianapolis , USA
Tue 10 09:30
Drug Discovery
Lecture 6 - More than a gut feeling: amylin, the next wave of obesity therapeutics.
Indianapolis , USA
Charlotte Frazer-Morris
Oxford, UK
Mon 09 15:45
OC3
Oral Presentations 2
Circadian rhythm disruption reduces GLP1 and GIP agonist efficacy in pancreatic beta cells
Oxford, UK
Tom Gardella
USA
Tue 10 13:30
Endocrine
Lecture 11 - Targeting the PTH-1R
USA
Fiona Gribble
Cambridge, United Kingdom
Mon 09 13:00
Appetite and Metabolism
Lecture 1 - Nutritional regulation of gut hormone secretion through GPCRs
Cambridge, United Kingdom
Salim Hanna
Copenhagen, Denmark
Mon 09 14:15
OC2
Oral Presentations 1
Two Succinate GPCR Pathways: Muscle Stem-Cell Sensing and Hypoxia-Induced Epithelial Signalling
Copenhagen, Denmark
Jakob Höppner
Boston, MA, USA
Tue 10 12:00
OC6
Oral Presentations 3
Ligand-PTH1R-βarrestin-complex stability dictates compartmentalized signaling
Boston, MA, USA
Ralf Jockers
Paris, France
Mon 09 14:45
Genetics
Lecture 3 - GLP1 receptor variants and their role in metabolic disease
Paris, France
Kim Jonas
London, UK
Tue 10 11:15
Reproductive
Lecture 9 - Uncovering the molecular control of gonadotrophin hormone receptor actions in reproductive health and ageing
London, UK
Simon Luckman
Manchester, UK
Tue 10 10:45
Reproductive
Lecture 8 - RFamide prolactin-releasing peptide analogue reduces body weight through a mechanism distinct from GLP1RA
Manchester, UK
Yusman Manchanda
London, UK
Tue 10 14:00
OC7
Oral Presentations 4
In vivo role of β-arrestin 2 and GLP-1R and GIPR biased signalling in α-cells
London, UK
Annabelle Milner
London, UK
Mon 09 14:00
OC1
Oral Presentations 1
Profiling GIPR signalling mechanisms underlying lipid metabolism rewiring in adipocytes
London, UK
Fiona Murray
Aberdeen, Scotland
Tue 10 13:00
Endocrine
Lecture 10 - From Orphan to Opportunity: Characterising the physiology and pharmacology of GPR75
Aberdeen, Scotland
Maria Shchepinova
Bath, UK
Tue 10 14:15
OC8
Oral Presentations 4
Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism.
Bath, UK
Alejandra Tomas Catala
London, UK
Mon 09 13:30
Appetite and Metabolism
Lecture 2 - Subcellular architecture of glucagon receptor family signalling
London, UK
Jan Voss
Denmark
Tue 10 09:00
Drug Discovery
Lecture 5 - De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
Denmark
Professor Giles Yeo
Cambridge, UK
Mon 09 15:15
Genetics
Lecture 4 - Mapping expression of metabolically relevant GPCRs in the human brain
Cambridge, UK
Mon 09 11:00
Registration, Lunch and Refreshments
Princes Suite Foyer (Registration) & Princes Suite 2 (Lunch, refreshments & exhibition)
Mon 09 12:45
Welcome & Introduction
Princes Suite 1
Chair: Peter McCormick (Liverpool, UK)
Mon 09 13:00
Appetite and Metabolism
Lecture 1 - Nutritional regulation of gut hormone secretion through GPCRs
Cambridge, United Kingdom
Mon 09 13:30
Appetite and Metabolism
Lecture 2 - Subcellular architecture of glucagon receptor family signalling
London, UK
Mon 09 14:00
OC1
Oral Presentations 1
Profiling GIPR signalling mechanisms underlying lipid metabolism rewiring in adipocytes
London, UK
Mon 09 14:15
OC2
Oral Presentations 1
Two Succinate GPCR Pathways: Muscle Stem-Cell Sensing and Hypoxia-Induced Epithelial Signalling
Copenhagen, Denmark
Mon 09 14:30
Coffee Break, exhibition
Princes Suite 2
Mon 09 14:45
Genetics
Lecture 3 - GLP1 receptor variants and their role in metabolic disease
Paris, France
Mon 09 15:15
Genetics
Lecture 4 - Mapping expression of metabolically relevant GPCRs in the human brain
Cambridge, UK
Mon 09 15:45
OC3
Oral Presentations 2
Circadian rhythm disruption reduces GLP1 and GIP agonist efficacy in pancreatic beta cells
Oxford, UK
Mon 09 16:00
OC4
Oral Presentations 2
SSTR2 Receptor States and Recycling Dynamics Shape the Apparent Affinity of 177Lu-DOTATATE
Uppsala, Sweden
Mon 09 16:15
Coffee Break, exhibition
Princes Suite 2
Mon 09 16:30
Keynote
Signalling at the nanoscale: spatiotemporal organisation of the cAMP/PKA pathway
UK
Mon 09 17:15
Networking Drinks & Posters
Princes Suite 2
Tue 10 08:00
Morning Coffee and refreshments, exhibition
Princes Suite 2
Tue 10 09:00
Drug Discovery
Lecture 5 - De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
Denmark
Tue 10 09:30
Drug Discovery
Lecture 6 - More than a gut feeling: amylin, the next wave of obesity therapeutics.
Indianapolis , USA
Tue 10 10:00
Drug Discovery
Lecture 7 - Three Names: CRN00808, paltusotine, Palsonify
USA
Tue 10 10:30
Coffee Break, exhibition
Princes Suite 2
Tue 10 10:45
Reproductive
Lecture 8 - RFamide prolactin-releasing peptide analogue reduces body weight through a mechanism distinct from GLP1RA
Manchester, UK
Tue 10 11:15
Reproductive
Lecture 9 - Uncovering the molecular control of gonadotrophin hormone receptor actions in reproductive health and ageing
London, UK
Tue 10 11:45
OC5
Oral Presentations 3
A GRK-Biased β₂-Adrenergic Receptor Agonist Induces Coordinated Fat Loss and Muscle Gain via Pathway-Selective Signaling
Solna, Sweden
Tue 10 12:00
OC6
Oral Presentations 3
Ligand-PTH1R-βarrestin-complex stability dictates compartmentalized signaling
Boston, MA, USA
Tue 10 12:15
Lunch, exhibition
Princes Suite 2
Tue 10 13:00
Endocrine
Lecture 10 - From Orphan to Opportunity: Characterising the physiology and pharmacology of GPR75
Aberdeen, Scotland
Tue 10 13:30
Endocrine
Lecture 11 - Targeting the PTH-1R
USA
Tue 10 14:00
OC7
Oral Presentations 4
In vivo role of β-arrestin 2 and GLP-1R and GIPR biased signalling in α-cells
London, UK
Tue 10 14:15
OC8
Oral Presentations 4
Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism.
Bath, UK
Tue 10 14:30
Coffee Break, exhibition
Princes Suite 2
Tue 10 14:45
Panel Discussion
Our final session brings a selection of our speakers together for an in‑depth closing panel, offering a fast‑paced overview of the key themes explored across the two‑day programme. This concluding discussion will highlight major insights, emerging trends, and shared challenges raised throughout the event.
Princes Suite 1
Tue 10 15:15
Poster Awards and Closing remarks from the Founding Group
Princes Suite 1

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