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Thursday 01 October 23 sessions
    07:30 - 19:00 
    Registration
    Registration
    08:00 - 11:00 
    Working Group WG1 - ESPE Bone and Growth Plate (BGP) Working Group
    Hall 3
    Chairs: Ola Nilsson (Stockholm, Sweden) & Gabriele Häusler (Vienna, Austria)
    WG1.1
    Short stature: blame the chondrocyte
    Jeffery Baron (Bethesda, USA)
    WG1.2
    The role of NFkB in growth plate chondrogenesis
    Francesco Luca (Philadelphia, USA)
    Coffee Break
    WG1.3
    Genetics of juvenile osteoporosis
    Outimaija Mäkitie (Helsinki, Finland)
    WG1.4
    Bone tissue characteristics in pediatric bone disease
    Nadja Fratzl-Zelman (Vienna, Austria)
    WG1.5
    Fracture prevention in cystic fibrosis
    Maria Bianchi (Milan, Italy)
    08:00 - 11:00 
    Working Group WG2 - ESPE Working Group on Diabetes Technology and Therapeutics
    Hall 1
    Chairs: Moshe Phillip (Petah Tikva, Israel) & Tadej Battelino (Ljubljana, Slovenia)
    Introductions
    Moshe Phillip (Petah Tikva, Israel)
    WG2.1
    New technologies in treating patients with type 2 diabetes
    Paolo Pozzilli (Rome, Italy)
    WG2.2
    Debate: Are genetic tests necessary before starting a treatment of a patient with Neonatal Diabetes?
    Michel Polak (Paris, France))
    WG2.3
    Debate: Are genetic tests necessary before starting a treatment of a patient with Neonatal Diabetes?
    Moshe Phillip (Petah Tikva, Israel)
    Coffee Break
    WG2.4
    Debate: Blood glucose monitoring - which is the better: continuous real-time or episodic real-time on demand?
    Revital Nimri (Petah Tikva, Israel)
    WG2.5
    Debate: Blood glucose monitoring - which is the better: continuous real-time or episodic real-time on demand?
    Olga Kordonouri (Hannover, Germany)
    WG2.6
    Type 2 diabetes mellitus in adolescence
    Thomas Reinehr (Datteln, Germany)
    WG2.7
    The rationale and potential role of surgery in the treatment of adolescent diabetes
    Thomas Inge (Cincinnati, USA)
    08:00 - 11:00 
    Working Group WG3 - ESPE Working Group on Disorders of Sex Development (DSD)
    Hall 2
    Chairs: Paul Martin Holterhus (Kiel, Germany) & Anna Nordenström (Stockholm, Sweden)
    Welcome
    Anna Nordenström (Stockholm, Sweden)
    WG3.1
    Maternal, placental and fetal steroid hormone synthesis: the key facts for understanding DSDs
    Christa Flück (Bern, Switzerland)
    WG3.2
    DSD in Indonesia: the course of psychological development in late identified patients
    Arianne Dessens (Rotterdam, The Netherlands)
    Coffee Break
    WG3.3
    Work accomplished by the European Reference Network
    WG3.4
    I-DSD and I-CAH registry update
    Faisal Ahmed (Glasgow, United Kingdom))
    WG3.5
    EU-Study: dsd-LIFE
    Birgit Köhler (Berlin, Germany)
    DSD Open Business Meeting
    Anna Nordenström (Stockholm, Sweden)
    08:00 - 11:00 
    Working Group WG4 - ESPE Obesity Working Group (OWG)
    Hall 7
    Chairs: Jesús Argente (Madrid, Spain) & Bessie Spiliotis (Patras, Greece)
    WG4.1
    The endocrine role of brown adipose tissue
    Francesc Villarroya
    WG4.2
    A monomeric peptide triagonist for the treatment of obesity and diabetes
    Christoffer Clemmensen (Munich, Germany)
    Coffee Break
    WG4.3
    Genetic approach to understanding severe early-onset childhood obesity
    Luis Pérez-Jurado (Barcelona, Spain)
    WG4.4
    Understanding gene-diet interactions as an approach for the treatment of obesity
    José Ordovás (Boston, USA)
    08:00 - 11:00 
    Working Group WG5 - ESPE Working Group on Paediatric and Adolescent Gynaecology (PAG)
    Hall 4
    Chairs: Marco Cappa (Rome, Italy) & Charles Sultan (Montpellier, France)
    WG5.1
    Impact of malignancies and their treatment on reproductive function in girls
    Charles Sklar (New York, USA)
    WG5.2
    Preservation of fertility pre-therapy
    Michaël Grynberg (Bondy, France)
    WG5.3
    Restoration of fertility in cancer adolescents after chemotherapy
    Jacques Donnez (Brussels, Belgium)
    Coffee Break
    WG5.4
    Diagnosis and management of endometriosis in adolescence
    Patrick Puttemans (Leuven, Belgium)
    WG5.5
    Uterus transplantation with live births – an update
    Mats Brännström (Gothenburg, Sweden)
    08:00 - 11:00 
    Working Group WG6 - ESPE Working Group on Turner Syndrome (TS)
    Hall 5
    Chairs: Siska Verlinde & Malcolm Donaldson / Ewa Malecka-Tendera & Jenielle van Alfen
    Welcome
    Berit Kriström (Umea, Sweden)
    WG6.1
    Incidental prenatal diagnosis of Turner Syndrome, perspectives of parents and professionals
    Jacqueline Pieters (Leiderdorp, The Netherlands)
    WG6.2
    The challenges of prenatal diagnosis: the experience of a supportive group for parents of children with TS
    Maura Foresti (Bologna, Italy)
    Coffee Break
    WG6.3
    Impact of age at start and GH dose for height gain and age at adult height in TS girls
    Berit Kriström (Umea, Sweden)
    WG6.4
    Management of middle ear and hearing problems in Turner's syndrome - how can we do better?
    Malcolm Donaldson (Glasgow, United Kingdom)
    WG6.5
    Report on the progress and difficulties on transdermal Estradiol supplementation in Europe
    Theo Sas (Rotterdam, The Netherlands)
    11:15 - 11:30 
    Opening Ceremony
    Hall 1
    11:30 - 12:00 
    Plenary 1
    Joint ESPE-ISPAD Session
    Hall 1
    Chairs: Ragnar Hanas (Uddevalla, Sweden) & Luis Castaño (Bilbao, Spain)
    PL1
    Genetic and environmental determinants of type 1 diabetes
    Marian Rewers (Colorado, USA)
    12:00 - 12:30 
    Plenary 2
    Joint ESPE-ISPAD Session
    Hall 1
    Chairs: Ragnar Hanas (Uddevalla, Sweden) & Luis Castaño (Bilbao, Spain)
    PL2
    New advances in monogenetic diabetes
    Andrew Hattersley
    12:30 - 14:00 
    Lunch, Visit to Posters and Exhibition
    12:30 - 13:30 
    P1 Mini-Poster Presentations
    Adrenal: P1-1 to P1-11
    Bone: P1-12 to P1-22
    Diabetes: P1-23 to P1-33
    Growth Hormone: P1-78 to P1-88
    Perinatal: P1-100 to P1-110
    12:45 - 13:45 
    Industry Sponsored Satellite Symposium 1
    14:00 - 15:30 
    Symposium 1 - The effect of hormonal abnormalities on Neurocognition
    Hall 3
    Chairs: Jesús Argente (Madrid, Spain) & George Chrousos (Athens, Greece)
    S1.1
    The effect of thyroid hormones on the brain
    Joanne Rovet (Toronto, Canada)
    S1.2
    The effect of diabetes mellitus on neurocognition
    Fergus Cameron (Victoria, Australia)
    S1.3
    The effects of growth hormone and anabolic androgenic steroids on the brain
    Alfhild Grönbladh (Uppsala, Sweden)
    14:00 - 15:30 
    Symposium 2 - Adipose tissue: Beyond classical concepts
    Hall 5
    Chairs: Martin Wabistch (Ulm, Germany) & Antje Körner (Leipzig, Germany)
    S2.1
    Brown adipose tissue and its therapeutic potential
    Sven Enerbäck (Gothenburg, Sweden)
    S2.2
    Is brown adipose tissue relevant to paediatrics?
    Vicente Gilsanz (Los Angeles, USA)
    S2.3
    Lipodystrophies: new approaches for diagnostic workup and treatment
    Corinne Vigouroux (Paris, France)
    14:00 - 15:30 
    Symposium 3 - Disorders of sex development: An update
    Hall 2
    Chairs: Nils Krone (Sheffield, UK) & Olaf Hiort (Luebeck, Germany)
    S3.1
    Novel genes identified in male and female sex development
    Ken McElreavey (Paris, France)
    S3.2
    Decision Making in DSD: Development of a Decision Support Tool.
    David Sandberg (Michigan, USA)
    S3.3
    Genetic and enviromental disruption of testicular function
    Olle Söder (Stockholm, Sweden)
    14:00 - 15:30 
    Symposium 4 - Management of thyroid disorders: Current best practice
    Hall 1
    Chairs: Jan-Maarten Wit (Leiden, The Netherlands) & Annette Greuters-Kieslich (Berlin, Germany)
    S4.1
    Screening, diagnosis and management of congenital hypothyroidism
    Heiko Krude (Berlin, Germany)
    S4.2
    Management of hyperthyroidism in children
    Scott Rivkees (Gainesville, USA)
    S4.3
    Genetics of congenital hypothyroidism and associated problems
    Jose Moreno (Madrid, Spain)
    15:30 - 16:00 
    Coffee Break
    16:00 - 17:00 
    Meet the Expert Sessions
    MTE1.1
    Management of adrenal tumours
    Constantine Stratakis (Rockville, USA)
    MTE2.1
    Translation of diabetes technologies to clinical practice
    Olga Kordonouri (Hannover, Germany)
    MTE3.1
    Challenges in the management of short stature
    Jesús Argente (Madrid, Spain)
    MTE4.1
    Use of hormone replacement in females with endocrine disorders
    Sophie Christin-Maitre (Paris, France)
    16:00 - 17:00 
    Controversies 1: Debate - Is bariatric surgery the management of choice for obese adolescents?
    Hall 4
    Chairs: Wieland Kiess (Leipzig, Germany) & Bessie Spiliotis (Athens, Greece)
    For the Motion
    Thomas Inge (Cincinnati, USA)
    Against the Motion
    Thomas Reinehr (Datteln, Germany)
    16:00 - 17:00 
    Yearbook of Paediatric Endocrinology
    Hall 1
    Chair: Franco Chiarelli (Chieti, Italy)
    YB1
    YB1.1
    Obesity and weight regulation
    Martin Wabitsch (Ulm, Germany))
    YB1.2
    Type 2 diabetes, metabolic syndrome and lipids
    Orit Pinhas-Hamiel (Tel Aviv, Israel))
    YB1.3
    Type 1 diabetes
    Wieland Kiess (Leipzig, Germany)
    YB1.4
    Evidence based medicine in pediatric endocrinology
    Rod Mitchell (Edinburgh, UK)
    YB1.5
    Editor's choice
    Ken Ong (Cambridge, United Kingdom))
    17:15 - 18:45 
    Industry Sponsored Satellite Symposium 2 - 4
    18:45 -  
    Welcome Reception
    Exhibition area
Friday 02 October 24 sessions
    07:30 - 19:00 
    Registration
    08:00 - 09:00 
    Meet the Expert Sessions
    MTE8.1
    Looking beyond nutritional rickets: From the foetus to the infant
    Wolfgang Högler (Linz, Austria)
    MTE5.1
    Management of the adolescent with CAH
    Peter Hindmarsh
    MTE6.1
    Management of Prader-Willi syndrome in toddlers
    Maithé Tauber (Toulouse, France)
    MTE7.1
    Management of late-effects in the child/adolescent with cancer
    Charles Sklar (New York, USA)
    09:15 - 10:15 
    Free Communications 1 - Adrenal
    Hall 2
    Chairs: Berenice Mendonca (Sao Paulo, Brazil) & Christa Flück (Bern, Switzerland)
    FC1.1
    A genomic atlas of human gonad and adrenal development
    John Achermann (London, United Kingdom)
    FC1.2
    Involvement of the Wnt/beta-catenin pathway, SF1, DAX1 and stem/progenitor cell markers in paediatric adrenocortical tumors (ACTs)
    Marcelo Cavalcanti (San Paolo, Brazil)
    FC1.3
    Aldosterone and mineralocorticoid receptor as inducers of immune markers in peripheral blood mononuclear cells: beyond elevating blood pressure
    Andrea Vecchiola (Santiago, Chile)
    FC1.4
    Congenital adrenal hyperplasia due to 21 OH deficiency: final height before and after newborn screening era in Emilia-Romagna region, Italy
    Bologna, Italy
    FC1.5
    Atypical presentation of six patients with mutations in the side chain cleavage enzyme CYP11A1
    Louise Metherell (London, UK)
    FC1.6
    An update on noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free foetal DNA in maternal plasma
    Maria New (New York, USA)
    09:15 - 10:15 
    Free Communications 2 - Bone & Mineral Metabolism
    Hall 3
    Chairs: Dov Tosiano (Israel) & Serap Turan (Istanbul, Turkey)
    FC2.1
    Whole exome sequencing analysis of patients with autosomal recessive hypophophatemic rickets identified mutations in DMP1, ENPP1 and SLC34A3
    Dong Li (Philadelphia, USA)
    FC2.2
    Identification of mutations in TBX1 and AIRE in isolated hypoparathyroidism patients
    Dong Li (Philadelphia, USA)
    FC2.3
    High success of a next generation sequencing panel for the molecular diagnosis of rare skeletal dysplasias
    Karen Heath (Madrid, Spain)
    FC2.4
    Asfotase alfa: sustained efficacy and tolerability in children with hypophosphatasia treated for 5 years
    Katherine Madson (St. Louis, USA)
    FC2.5
    Methyl donor deficiency impairs differentiation of pre-osteoblasts through disruption of functional interaction between peroxisome proliferator-activated receptor-gamma coactivator-1 alpha and vitamin D receptor
    Eva Feigerlova (Nancy, France)
    FC2.6
    A contextual feature-based recognition approach to quantify trabecular microstructure using 1.5T axial-MRI: an innovative methodology
    Paul Dimitri (Sheffield, UK)
    09:15 - 10:15 
    Free Communications 3 - Diabetes
    Hall 4
    Chairs: Alfonso Lechuga (Spain) & Silva Arslanian
    FC3.1
    RNA-based MAFA over-expression is sufficient to drive human pancreatic duct-derived cells toward a -cell-like phenotype
    Elisa Corritore (Brussels, Belgium)
    FC3.2
    Experience with molecular diagnosis in 48 cases of neonatal diabetes mellitus using targeted next-generation sequencing
    Yulia Tikhonvich (Moscow, Russia)
    FC3.3
    Clinical characteristics and molecular genetic analysis of 6 patients with pancreas aplasia and neonatal diabetes: predominance of PTF1A-enhancer mutations
    Klemens Raile (Berlin, Germany)
    FC3.4
    Wolfram syndrome: natural history and genotype-phenotype correlation based on EURO-WABB Registry show gender differences in disease severity
    Renuka Dias
    FC3.5
    C-peptide levels and glycemic control in children, adolescents and young adults with type 1 diabetes (TID)
    Maria Xatzipsalti (Athens, Greece)
    FC3.6
    First report of nationwide incidence and prevalence of type 1 diabetes among children in Turkey
    Ediz Yesilkaya (Ankara, Turkey)
    09:15 - 10:15 
    Free Communications 4 - Growth
    Hall 5
    Chairs: Jovanna Dahlgren & Gary Butler (London, UK)
    FC4.1
    Heterozygous dominant negative STAT5B variants associated with short stature and GH insensitivity
    Evelien Pease-Gevers (London, UK)
    FC4.2
    A recurrent homozygous NDUFB3 mutation, p.Trp22Arg causes a short stature disorder and mitochondrial protein complex I deficiency with a variable metabolic phenotype
    Philip Murray (Manchester, UK)
    FC4.3
    An updated and final analysis of a randomised placebo-controlled trial of the effect of oxandrolone and timing of pubertal induction on final height in Turner syndrome
    Emma-Jane Gault (Glasgow, UK)
    FC4.4
    Modulation of GH-1 splicing as potential strategy to rescue growth hormone deficiency type II
    Maria Mileta (Bern, Switzerland)
    FC4.5
    Stunted growth after inhaled corticosteroid use during the first 24 months of life
    Antti Saari (Kuopio, Finland)
    FC4.6
    Positive association between height and cancer in the Swedish population
    Emelie Benyi (Stockholm, Sweden)
    09:15 - 10:15 
    Free Communications 5 - Endocrine Oncology / Turner Syndrome
    Hall 7
    Chairs: (Mohammed Maghnie (Genoa, Italy) & Cristina Azcona (Pamplona, Spain)
    FC5.1
    Resveratrol potentiates growth inhibitory effects of rapamycin in PTEN-deficient lipoma cells by suppressing p70S6 kinase activity
    Jenny Leipert (Leipzig, Germany)
    FC5.2
    MEN1 syndrome because of combined germline and somatic mosaicism, with important consequences for relatives
    Marlies Kempers (Nijmegen, The Netherlands)
    FC5.3
    Screening in children with Succinate dehydrogenase B (SDHB) mutations: a single centre’s family clinic experience
    Lucy Shapiro (London, UK)
    FC5.4
    X chromosome gene dosage and the risk of developing congenital and acquired traits in Turner syndrome: a cross-sectional database analysis of the French national rare disease network
    Delphine Zenaty (Paris, France)
    FC5.5
    Hereditary Turner syndrome 46,X,rec(X)inv(p21q28) in six women and four generations: estimation of skeletal effects of growth hormone treatment
    Judith Stoklasova (Prague, Czech Republic)
    FC5.6
    Anti-Müllerian hormone levels in patients with Turner syndrome: relation to karyotype, pubertal development and growth hormone therapy
    Rasha Hamza (Cairo, Egypt)
    09:15 - 10:15 
    Yearbook of Paediatric Endocrinology
    Hall 1
    Chair: Primus Mullis (Bern, Switzerland)
    YB2
    YB2.1
    Pituitary and neuroendocrinology
    Nicolas Roux (Paris, France))
    YB2.2
    Reproductive Endocrinology
    Olle Söder (Stockholm, Sweden)
    YB2.3
    Antenatal and Neonatal Endocrinology
    Khalid Hussain (Doha, Qatar))
    YB2.4
    Growth and growth factors
    Stefano Cianfarani (Rome, Italy)
    YB2.5
    Type 1 diabetes
    Wieland Kiess (Leipzig, Germany)
    09:15 - 10:15 
    New Perspectives Session 1
    Hall 6
    Chair: Cheri Deal (Montreal, Canada)
    NP1.1
    Pancreatic development using zebrafish as a model
    Didier Stainier (Bad Nauheim, Germany)
    NP1.2
    Optogenetic control of neuroendocrine hormone secretion
    Allan Herbison
    10:45 - 11:15 
    Plenary 3
    Hall 1
    Chairs: Jean-Claude Carel (Paris, France) & Mehul Dattani (London, UK)
    PL3
    New advances in human evolution from the analysis of ancient genomes
    Carles Lalueza-Fox (Barcelona, Spain)
    11:15 - 12:15 
    ESPE Awards and Activities 1
    Hall 1
    Chairs: Anita Hokken-Koelega (Rotterdam, The Netherlands) & Jan Lebl (Prague, Czech Republic)
    ESPE Young Investigator Award 1 & 2 – sponsored by Pfizer
    ESPE Schools – sponsored by ESPE (Diabetes, Obesity and Metabolism School), Ferring Pharmaceuticals (Summer, Winter and Caucasus & Central Asia Schools), Novo Nordisk Gulf (ASPED-ESPE School), and Pfizer (Maghreb School)
    ESPE Fellowships and Sabbatical Leave Programme – sponsored by Novo Nordisk A/S (Research Fellowship), Merck Serono SA (Clinical Fellowship) and Eli Lilly and Company (Sabbatical Leave Programme)
    ESPE Hormone Research in Paediatrics Prizes – sponsored by Karger A.G.
    ESPE International Award – sponsored by Pfizer
    ESPE Research Award – sponsored by Pfizer
    12:15 - 12:45 
    Plenary 4
    Hall 1
    Chairs: Jean-Claude Carel (Paris, France) & Mehul Dattani (London, UK)
    PL4
    Genomic diversity in present day humans: Evolutionary aspects
    Alan Templeton (St Louis, USA)
    12:45 - 14:30 
    Lunch, Visit to the Posters and Exhibition
    12:45 - 13:45 
    P1 Mini Poster Presentations
    Diabetes: P1-34 to P1-44
    DSD: P1-56 to P1-66
    Growth: P1-89 to P1-99
    Turner & Puberty: P1-133 to P1-143
    Misc: P1-144 to P1-154
    13:15 - 14:15 
    Industry Sponsored Satellite Symposium 5
    14:15 - 16:15 
    ESPE Working Group for Paediatic Endocrine Nurse Specialists and Allied Health Professionals (PENSWG)
    Hall 6
    Chairs: Kate Davies (London, UK) & Christine Derycke (Brussels, Belgium)
    WG7.1
    Nurse run short stature screening clinic
    Wendy Schwarz
    WG7.2
    Quality management initiatives in pediatric endocrinology: Selected case study and clinical initiatives
    Irena Hozjan
    Q & A from the first two speakers
    WG7.3
    Getting a patient off of medication due to coaching and care. A case report
    Viviane Crommert
    WG7.4
    Long-term outcome of a male preschooler treated for central precocious puberty
    Jan Foote (Iowa, USA)
    WG7.5
    Pan-Canadian experience of pediatric endocrine nurses assisting youth through gender transition
    Nicole Kirouac (Manitoba, Canada)
    Q & A from the above case study speakers
    WG7.6
    Sharing Resources:  Hypothyroidism 
    Christine Davies
    14:30 - 16:00 
    Symposium 5 - Developmental Programming: Novel concepts
    Hall 5
    Chairs: Stefano Cianfarani (Rome, Italy) & Ruben Diaz (Spain)
    S5.1
    Developmental programming of reproductive function: Early life nutritional impacts
    Deborah Sloboda (Hamilton, Canada)
    S5.2
    Transgenerational developmental programming of endocrine disease
    Susan Ozanne
    S5.3
    Intergenerational programming of metabolic disease
    Mary Patti (Boston, USA)
    14:30 - 16:00 
    Symposium 6 - Type 2 Diabetes & Obesity
    Hall 1
    Chairs: Tadej Battelino (Ljubljana, Slovenia) & Jan Lebl (Prague, Czech Republic)
    S6.1
    Can genotype be used to tailor treatment of obesity?
    José Ordovás (Boston, USA)
    S6.2
    New and old drugs for treatment of type 2 diabetes in children
    David Dunger
    S6.3
    From obesity to type 2 diabetes
    Silva Arslanian (Pittsburgh, USA)
    14:30 - 16:00 
    Symposium 7 - Hypogonadotropic hypogonadism: diagnostic and therapeutic approach
    Hall 2
    Chairs: Nicholas de Roux (Paris, France) & Maria Clemente
    S7.1
    Early therapeutic approach to the male patient with HH
    Claire Bouvattier (Paris, France)
    S7.2
    Pubertal induction and fertility prospects in the male
    Nelly Pitteloud (Lausanne, Switzerland)
    S7.3
    Modeling GnRH deficiency with the use of human pluripotent cells
    Taneli Raivio (Helsinki, Finland)
    14:30 - 15:30 
    Controversies 2: Debate - Should pre-natal treatment for CAH be offered?
    Hall 4
    Chair: Peter Hindmarsh (London, UK)
    For the Motion
    Véronique Tardy-Guidollet (Lyon, France)
    Against the Motion
    Svetlana Lajic (Stockholm, Sweden)
    14:30 - 16:00 
    Special Symposium - Recommendations for surveillance for thyroid cancer in survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
    Hall 3
    Chair: Hanneke van Santen
    SS1.1
    Introduction of the IGHG-thyroid group, its members and aims
    Dr endocrinologist,
    SS1.2
    Methodology of the IGHG recommendations
    Drs recommendation,
    SS1.3
    Which cancer survivors are at risk for thyroid cancer; summary of the evidence
    Dr endocrinologist, (Tennessee, USA)
    SS1.4
    Is detection of thyroid cancer in an early stage beneficial ?
    Drs Clement,
    SS1.5
    Which evaluation modality is most sensitive and specific for detecting thyroid carcinoma in an early stage; summary of the evidence and decision tree analysis.
    Dr Goldfarb (California, USA)
    SS1.6
    Pro-Con debate - Arguments in favour of screening survivors at risk with palpation of the neck
    Dr Frey, (Vienna, Austria)
    SS1.6
    Pro - Con Debate: Arguments in favour of screening survivors at risk with thyroid ultrasound
    Scott Rivkees (Gainesville, USA)
    SS1.7
    Further steps of the IGHG group; forming a decision aid.
    HM Santen
    14:30 - 16:00 
    Special Symposium - Opportunities and challenges in accessing essential medications in low and middle income countries
    Hall 7
    Chair: Reiko Horikawa (Japan)
    SS2.1
    Facilitating Access to Essential Medicines: role of WHO
    Suzanne Hill ((Geneva, Switzerland))
    SS2.2
    Bringing essential medicines into low income countries: opportunities and challenges for the pharmaceutical
    Avinash Shejale ((Mumbai, India))
    SS2.3
    A model for the sustainable access to medicines for the management of congenital adrenal hyperplasia (CAH) in a low income setting
    Jean-Pierre Chanoine (Vancouver, Canada))
    16:15 - 17:45 
    ESPE Annual Business Meeting
    ESPE Members Only
    18:00 - 19:30 
    Industry Sponsored Satellite Symposium 6 - 8
Saturday 03 October 30 sessions
    07:30 - 18:30 
    Registration
    08:00 - 09:00 
    Meet the Expert Sessions
    MTE1.2
    Management of adrenal tumours
    Constantine Stratakis (Rockville, USA)
    MTE3.2
    Challenges in the management of short stature
    Jesús Argente (Madrid, Spain)
    MTE4.2
    Use of hormone replacement in females with endocrine disorders
    Sophie Christin-Maitre (Paris, France)
    MTE7.2
    Management of late-effects in the child/adolescent with cancer
    Charles Sklar (New York, USA)
    MTE2.2
    Translation of diabetes technologies to clinical practice
    Olga Kordonouri (Hannover, Germany)
    09:15 - 10:15 
    New Perspectives Session 2
    Hall 7
    Chairs: Ze'ev Hochberg (Haifa, Israel) & Gabriele Haeusler
    NP2.1
    Engineering cartilage
    Marcel Karperien (Enschede, The Netherlands)
    NP2.2
    Astrocytes and neuroendocrine control
    Julie Chowen (Madrid, Spain)
    09:15 - 10:15 
    New Technologies Session
    Hall 6
    Chairs: Ken Ong (Cambridge, UK) & Laura De Graff (The Netherlands)
    NT1
    New technologies in imaging
    Chris Clark (London, UK)
    NT2
    Next Generation Sequencing: Implementing the 100,000 genome project for treatment of NHS patients
    Tim Hubbard (London, UK)
    09:15 - 10:15 
    Free Communications 6 - Gonads & DSD
    Hall 1
    Chairs: Tsutomu Ogata (Japan) & John Achermann (London, UK)
    FC6.1
    Correlation of AR expression and AR transcriptional activity in cultured human genital fibroblasts
    Nadine Hornig (Kiel, Germany)
    FC6.2
    A role for DMRT1 in human primary sex-determination
    Sandra Rojo (Minneapolis, USA)
    FC6.3
    Establishing the role of the steroid backdoor pathway for androgen biosynthesis in the human ovary
    Nesa May (Bern, Switzerland)
    FC6.4
    Severe 46, XY disorder of sex development (DSD) due to CBX2 isoform 2 mutation is distinct from CBX2.1 deficiency and is likely due to EMX2 dysregulation in the human developing gonad
    Wassim Eid (Fribourg, Switzerland)
    FC6.5
    Characterisation of mutations in the androgen receptor (AR) identified in 38 Brazilian families with complete or partial androgen insensitivity syndrome (AIS)
    Rafael Batista (Sao Paulo, Brazil)
    FC6.6
    Frequency of gonadal tumour in complete androgen insensitivity syndrome (CAIS): a retrospective case-series analysis
    Saduf Chaudhry (Cambridge, UK)
    09:15 - 10:15 
    Free Communications 7 - Growth promoting therapies
    Hall 2
    Chairs: Gerhard Binder (Tuebingen, Germany) & Alexander Augusto de Lima Jorge (São Paulo, Brazil)
    FC7.1
    Safety and effectiveness of Increlex® therapy in children with Laron syndrome and enrolled in the European Increlex® Growth Forum Database (EU-IGFD) in Europe
    Peter Bang (Linköping, Sweden)
    FC7.2
    Topicon™ ThermoMatrix™-mediated passive transdermal delivery of insulin-like growth factor 1 (IGF-1) Across EpidermFT™ full-thickness human skin equivalent (HSE): towards an extended-wear IGF-1 Patch
    Stephen Hsu (Florida, USA)
    FC7.3
    IGF-I levels, complex formation and igf-bioactivity in growth hormone treated children with Prader-Willi syndrome
    Nienke Bakker (Rotterdam, The Netherlands)
    FC7.4
    A novel reversible albumin-binding growth hormone derivative possesses a promising once-weekly treatment profile in children with growth hormone deficiency
    Tadej Battelino (Ljubljana, Slovenia)
    FC7.5
    12 month safety and efficacy of a weekly long-acting growth hormone (GH, MOD-4023) compared to daily recombinant human GH (rh)GH) therapy in pre-pubertal growth hormone deficient children; Phase 2 study – Study CP-4-004 Summary
    Ron Rosenfeld (Oregon, USA)
    FC7.6
    Pharmacokinetic (PK) and pharmacodynamics (PD) modelling of MOD 4023 (a long-acting human growth hormone (hGH)) in growth hormone deficient (GHD) children
    Gili Hart (Nes Ziona, Israel)
    09:15 - 10:15 
    Free Communications 8 - Obesity Basic
    Hall 3
    Chairs: Jean-Pierre Chanoine & Carlo Acerini (Cambridge, UK)
    FC8.1
    DLK1 expression in adipose tissue following fetal growth restriction: relation to visceral fat expansion and catch-up growth in Wistar rats
    Gemma Carreras-Badosa (Girona, Spain)
    FC8.2
    Apoptosis inhibitor of macrophages (AIM): an anti-inflammatory adipocyte factor in mild adolescent obesity?
    Alexia Karvela (Patras, Greece)
    FC8.3
    Testing the Appetite Suppressing Effects of Vitamin B12 Conjugates of Peptide YY
    Christian Roth (Seattle, USA)
    FC8.4
    Severe early-onset obesity caused by bioinactive leptin due to a N103K mutation
    Martin Wabitsch (Ulm, Germany))
    FC8.5
    Adipocytokines in placenta and cord blood in relation to maternal obesity, and foetal and postnatal growth of the child
    Maria Lodefalk (Örebro, Sweden)
    FC8.6
    Metabolic effects of ADP355, protein-based adiponectin receptor agonist, on mice with high-fat diet induced fatty liver disease
    Eun Lee (Inchon, Republic of Korea)
    09:15 - 10:15 
    Free Communications 9 - Beta cell disorders
    Hall 4
    Chairs: John Gregory (Cardiff, UK) & Ritika Kapoor
    FC9.1
    Islet δ-cells contribute to the pathobiology of atypical congenital hyperinsulinism
    Bing Han (Manchester, UK)
    FC9.2
    A novel source of mesenchymal stem cells lines from the human neonatal pancreas of patients with congenital hyperinsulinism in infancy
    Sophie Kellaway (Manchester, UK)
    FC9.3
    Failure to terminate cell proliferation contributes to the pathobiology of congenital hyperinsulinism in infancy
    Bing Han (Manchester, UK)
    FC9.4
    Novel molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8
    Azizun Nessa (London, UK)
    FC9.5
    The use of glucagon for management of severe-persistent hypoglycaemia in patients with congenital hyperinsulinism
    Klaus Mohnike (Magdeburg, Germany)
    FC9.6
    Pharmacokinetics (PK) of a new suspension of glibenclamide for use in young patients and infants with neonatal diabetes
    Jacques Beltrand (Paris, France))
    10:45 - 11:45 
    ESPE Awards and Activities 2
    Hall 1
    Chairs: Laura Audí (Barcelona, Spain) & Lars Sävendahl (Stockholm, Sweden)
    Henning Andersen Prizes – sponsored by Novo Nordisk A/S
    ESPE Research Unit – sponsored by ESPE and Sandoz International GmbH
    IFCAH-ESPE award – supported by The International Fund for Research on Congenital Adrenal Hyperplasia
    ESPE Outstanding Clinician Award – sponsored by Pfizer
    ESPE International Outstanding Clinician Award – sponsored by Pfizer
    Andrea Prader Prize – sponsored by Pfizer
    11:45 - 12:15 
    Plenary 5
    Hall 1
    Chair: Lourdes Ibanez
    PL5
    Ontogeny of FGF21 in the human: Implications for metabolic health
    Francesc Villarroya
    12:30 - 13:30 
    Yearbook of Paediatric Endocrinology
    Hall 1
    Chair: Juliane Léger (Paris, France)
    YB3
    YB3.1
    Adrenals
    Evangelia Charmandari (Athens, Greece))
    YB3.2
    THyroid
    Gabor Szinnai (Basel, Switzerland)
    YB3.3
    Bone, Growth plate and mineral metabolism
    Outi Mäkitie (Helsinki, Finland)
    YB3.4
    Oncology and chronic disease
    Carla Bizzarri (Rome, Italy))
    YB3.5
    The Year in Science and Medicine
    Ze'ev Hochberg (Haifa, Isreal))
    12:30 - 13:30 
    Free Communications 10 - Perinatal endocrinology
    Hall 2
    Chairs: Rod Mitchell (Edinburgh, UK) & Irène Netchine (Paris, France)
    FC10.1
    Effect of sonic hedgehog signalling on regulation the expression of 11β-HSD2 in the placenta
    Chao Zou (Hangzhou, China)
    FC10.2
    The altered circulating miRNA profile in maternal obesity associate with pre- and post-natal growth
    Judit Bassols (Salt, Spain)
    FC10.3
    Circulating miRNA expression profile in pregestational and gestational obesity
    Judit Bassols (Salt, Spain)
    FC10.4
    Effect of P450 oxidoreductase variants on metabolism by cytochrome P450 proteins
    Shaheena Parween (Bern, Switzerland)
    FC10.5
    Lack of association between transient hypothyroxinaemia of prematurity and neurodevelopmental and behavioral outcomes in young adulthood
    Josephina Hollanders (Amsterdam, The Netherlands)
    FC10.6
    Heterozygous hypomorphic mutation in the INS gene could cause transient neonatal diabetes in extremely low birth weight neonates
    Tohru Yorifuji (Osaka, Japan)
    12:30 - 13:30 
    Free Communications 11 - Neuroendocrinology
    Hall 3
    Chairs: Ivo Arnhold (Sao Paulo, Brazil) & Malcolm Donaldson (Glasgow, Scotland)
    FC11.1
    Mutations in BRAF are associated with septo-optic dysplasia and cardiofaciocutaneous syndrome
    Rachel Besser
    FC11.2
    Functional characterisation of a POU1F1 mutation unexpectedly associated with isolated growth hormone deficiency (IGHD): a novel aetiology of IGHD
    Marie-Laure Sobrier (Paris, France)
    FC11.3
    Next generation sequencing: towards a new clinical frontier in the diagnosis and management of pituitary tumours
    Mark McCabe (New South Wales, Australia)
    FC11.4
    Idiopathic multiple pituitary hormone deficiency (IMPHD): radiological and perinatal factors
    Nimasari Ginige (Birmingham, UK)
    FC11.5
    Endocrinopathy after intracranial germ cell tumours (IGCT) is disease not radiation- related: two decades of surveillance in a large tertiary paediatric cohort
    Eftychia Dimitrakopoulou (London, UK)
    FC11.6
    Long-term outcome of patients treated for paediatric Cushing's disease
    Galina Yordanova (London, UK)
    12:30 - 13:30 
    Free Communications 12 - Obesity clinical
    Hall 4
    Chairs: Juan-Pedro Lopez-Siguero & Veronica Mericq
    FC12.1
    Evaluation of cardiovascular risk in childhood: data from a survey of dyslipidaemic children
    Patrizia Bruzzi (Modena, Italy)
    FC12.2
    Soluble CD163, a circulating marker of macrophage activation, associates with a less favourable metabolic profile in children
    Gemma Carreras-Baosa (Girona, Spain)
    FC12.3
    Re-classification of childhood obesity by steroid metabolomic disease signature
    Aneta Gawlik (Katowice, Poland)
    FC12.4
    RM-493, a melanocortin-4 receptor (MC4R) agonist, is being therapeutically evaluated in patients with deficiencies in the Leptin – Proopiomelanocortin (POMC) – MC4R hypothalamic pathway, including Prader-Willi syndrome (PWS)
    Peter Kühnen (Berlin, Germany)
    FC12.5
    Link between body mass index and insulin requirement in children and young people with type 1 diabetes mellitus
    Swathi Upadrasta (Ormskirk, UK)
    FC12.6
    Initial experience with endoscopically placed duodenal-jejunal bypass liner (Endobarrier®) in morbidly obese adolescents
    12:30 - 13:30 
    Free Communications 13 - Thyroid
    Hall 5
    Chair: Michel Polak (Paris, France)
    FC13.1
    Gain of function STAT3 mutation in a boy with early onset autoimmune diabetes and thyroid disease, prenatal and postnatal growth impairment and lymphoproliferation
    Hana Sediva (Prague, Czech Republic)
    FC13.2
    Analysis of chosen polymorphisms rs2476601 A/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 A/G - TSHR in pathogenesis of autoimmune thyroid diseases in children
    Aleksandra Goralczyk (Bialystok, Poland)
    FC13.3
    Targeted next-generation sequencing demonstrates high frequency of ‘dyshormonogenesis genes’ mutations in severe congenital hypothyroidism
    Nina Makretskaya (Moscow, Russia)
    FC13.4
    Effects of initial levothyroxine dose on growth and neurodevelopmental outcomes during the first year of life in children with congenital hypothyroidism
    Andrea Esposito (Naples, Italy)
    FC13.5
    Effect of two years of treatment with levothyroxine on cardiovascular risk factors in children with mild idiopathic subclinical hypothyroidism
    Manuela Cerbone (London, UK)
    FC13.6
    TRIAC treatment of allan-herndon-dudley syndrome (AHDS) due to defects in thyroid hormone transporter MCT8
    A Iglesias (Madrid, Spain)
    12:30 - 13:30 
    Free Communications 14 - Puberty
    Hall 7
    Chairs: Dolores Rodriquez-Amao & Abdullah Bereket
    FC14.1
    KLB, encoding the co-receptor for FGF21, is mutated in congenital hypogonadotropic hypogonadism
    Cheng Xu (Lausanne, Switzerland)
    FC14.2
    A mutation in HS6ST1 causes self-limited delayed puberty
    Sasha Howard
    FC14.3
    The new syndrome of hypogonadotropic hypogonadism, arrythmogenic right ventricular dysplasia, facial dysmorphism and absence of corpus callosum is associated to TAX1 binding protein 3 gene mutation
    Eli Hershkovitz (Beer Sheva, Israel)
    FC14.4
    Genetic variation of AMH signaling affects AMH and inhibin B levels in healthy peripubertal girls
    Casper Hagen (Copenhagen, Denmark)
    FC14.5
    Polybrominated diphenyl ethers (PBDEs) and timing of puberty in girls
    Annalisa Deodati (Rome, Italy)
    FC14.6
    An evaluation of glandular breast tissue development and volume by MRI in 121 healthy peripubertal girls
    Louise Fugl (Copenhagen, Denmark)
    12:30 - 13:30 
    Free Communications 15 - Late Breaking
    Hall 6
    Chairs: Carlos Longui & Olle Söder (Stockholm, Sweden)
    FC-LB-1
    RNA Sequencing Reveals The Pathways Perturbed by Redox Imbalance in Nicotinamide Nucleotide Transhydrogenase null mice.
    Eirini Meimaridou
    FC-LB-2
    Loss of Neuronal Dmxl2 impairs the maturation and the activation of GnRH neurons: a new mechanism of GnRH deficiency.
    Carole Harbulot (Paris, France)
    FC-LB-3
    Pharmacokinetic and Pharmacodynamic Studies of Topicon™-Mediated Patch Delivery of Insulin Glargine in a Streptozotocin-Induced Hairless Rat Model
    Stephen Hsu (Florida, USA)
    FC-LB-4
    Long-term cognitive effects of antenatal dexamethasone treatment in Swedish adolescents with and without CAH
    Lena Wallensteen (Stockholm, Sweden)
    FC-LB-5
    Paternally inherited IGF2 mutation results in intrauterine and postnatal growth retardation
    Gerhard Binder (Tübingen, Germany)
    FC-LB-6
    PROP1 mutations cause hypopituitarism by disrupting the transition of pituitary stem cells to differentiation
    Maria Millan (Michigan, USA)
    13:30 -  
    Lunch, Visit to the Posters and Exhibition
    13:30 - 14:30 
    P1 Mini Poster Presentations
    Diabetes: P1-45 to P1-55
    Fat: P1-67 to P1-77
    Puberty: P1-111 to P1-121
    Thyroid: P1-122 to P1-132
    Misc: P1-155 to P1-165
    13:45 - 15:15 
    ESPE Education and Training
    Hall 6
    14:00 - 15:00 
    Industry Sponsored Satellite Symposium 9
    15:30 - 17:00 
    Symposium 8 - Diabetes & Obesity as infectious diseases
    Hall 1
    Chairs: Maria Chueca (Spain) & Zdenek Sumnik (Prague, Czech Republic)
    S8.1
    Disentangling disease and drug signatures in the human gut microbiome
    Oluf Pedersen (Copenhagen, Denmark)
    S8.2
    The role of the gut microbiome for immunity and metabolism
    Rémy Burcelin (Toulouse, France)
    S8.3
    Gut microbiome modulates the risk for islet autoimmunity
    Ondrej Cinek (Prague, Czech Republic)
    15:30 - 17:00 
    Symposium 9 - Childhood Craniopharyngioma: Recent Advances
    Hall 2
    Chairs: Lidia Castro (Santiago de Compostela, Spain) & Helen Spoudeas (London, UK)
    S9.1
    Outcomes in patients with childhood craniopharyngioma
    Hermann Mueller (Oldenburg, Germany)
    S9.2
    Surgical approach to craniopharyngioma
    Michael Buchfelder (Erlangen, Germany)
    S9.3
    Potential novel therapies for craniopharyngioma: Insights from a mouse model
    Carles Gaston-Massuet
    15:30 - 17:00 
    Symposium 10 - Growth plate & nutrition
    Hall 4
    Chairs: Faisal Ahmed (Glasgow, UK) & Agnes Linglart (Paris, France)
    S10.1
    Molecular mechanisms of growth plate adaptation during undernutrition
    Francesco Luca (Philadelphia, USA)
    S10.2
    Molecular response of the growth plate to inflammatory cytokines
    Lars Sävendahl (Stockholm, Sweden)
    S10.3
    Bone health in chronic disease
    Jarod Wong
    15:30 - 16:30 
    Meet the Expert Sessions
    MTE5.2
    Management of the adolescent with CAH
    Peter Hindmarsh
    MTE6.2
    Management of Prader-Willi syndrome in toddlers
    Maithé Tauber (Toulouse, France)
    MTE8.2
    Looking beyond nutritional rickets: From the foetus to the infant
    Wolfgang Högler (Linz, Austria)
    17:00 - 17:30 
    Coffee Break
    17:30 - 17:45 
    President Poster Award
    Hall 1
    Chair: Laura Audí (Barcelona, Spain)
    17:45 - 18:15 
    Plenary 6
    Hall 1
    Chairs: Peter Clayton (Manchester, UK) & Mitch Geffner (Los Angeles, UK)
    PL6
    The complex relationship between the GH/IGF axis and aging and longevity – the interface with diet and mitochondrial peptides
    Pinchas Cohen (Los Angeles, USA)
    18:15 - 18:30 
    Closing Ceremony
    Hall 1
    Chairs: Laura Audí (Barcelona, Spain), Peter Clayton (Manchester, UK) & Jean-Claude Carel (Paris, France)
    19:00 - 23:59 
    ESPE Evening
Allan Herbison
Allan Herbison
NP1.2
Fri 02 09:15 New Perspectives Session 1
Optogenetic control of neuroendocrine hormone secretion
Carles Gaston-Massuet
Carles Gaston-Massuet
S9.3
Sat 03 15:30 Symposium 9 - Childhood Craniopharyngioma: Recent Advances
Potential novel therapies for craniopharyngioma: Insights from a mouse model
Francesc Villarroya
Francesc Villarroya
WG4.1
Thu 01 08:00 Working Group WG4 - ESPE Obesity Working Group (OWG)
The endocrine role of brown adipose tissue
Francesc Villarroya
Francesc Villarroya
PL5
Sat 03 11:45 Plenary 5
Ontogeny of FGF21 in the human: Implications for metabolic health
Olga Kordonouri
Olga Kordonouri
WG2.5
Thu 01 08:00 Working Group WG2 - ESPE Working Group on Diabetes Technology and Therapeutics
Debate: Blood glucose monitoring - which is the better: continuous real-time or episodic real-time on demand?
Olga Kordonouri
Olga Kordonouri
MTE2.1
Thu 01 16:00 Meet the Expert Sessions
Translation of diabetes technologies to clinical practice
Olga Kordonouri
Olga Kordonouri
MTE2.2
Sat 03 08:00 Meet the Expert Sessions
Translation of diabetes technologies to clinical practice
Rod Mitchell
Rod Mitchell
YB1.4
Thu 01 16:00 Yearbook of Paediatric Endocrinology
Evidence based medicine in pediatric endocrinology
Ron Rosenfeld
Ron Rosenfeld
FC7.5
Sat 03 09:15 Free Communications 7 - Growth promoting therapies
12 month safety and efficacy of a weekly long-acting growth hormone (GH, MOD-4023) compared to daily recombinant human GH (rh)GH) therapy in pre-pubertal growth hormone deficient children; Phase 2 study – Study CP-4-004 Summary
Dong Li
Dong Li
FC2.1
Fri 02 09:15 Free Communications 2 - Bone & Mineral Metabolism
Whole exome sequencing analysis of patients with autosomal recessive hypophophatemic rickets identified mutations in DMP1, ENPP1 and SLC34A3
Dong Li
Dong Li
FC2.2
Fri 02 09:15 Free Communications 2 - Bone & Mineral Metabolism
Identification of mutations in TBX1 and AIRE in isolated hypoparathyroidism patients
Maria Lodefalk
Maria Lodefalk
FC8.5
Sat 03 09:15 Free Communications 8 - Obesity Basic
Adipocytokines in placenta and cord blood in relation to maternal obesity, and foetal and postnatal growth of the child
Outimaija Mäkitie
Outimaija Mäkitie
WG1.3
Thu 01 08:00 Working Group WG1 - ESPE Bone and Growth Plate (BGP) Working Group
Genetics of juvenile osteoporosis
Stefano Cianfarani
Stefano Cianfarani
YB2.4
Fri 02 09:15 Yearbook of Paediatric Endocrinology
Growth and growth factors
Eva Feigerlova
Eva Feigerlova
FC2.5
Fri 02 09:15 Free Communications 2 - Bone & Mineral Metabolism
Methyl donor deficiency impairs differentiation of pre-osteoblasts through disruption of functional interaction between peroxisome proliferator-activated receptor-gamma coactivator-1 alpha and vitamin D receptor
Manuela Cerbone
Manuela Cerbone
FC13.5
Sat 03 12:30 Free Communications 13 - Thyroid
Effect of two years of treatment with levothyroxine on cardiovascular risk factors in children with mild idiopathic subclinical hypothyroidism
Olle Söder
Olle Söder
S3.3
Thu 01 14:00 Symposium 3 - Disorders of sex development: An update
Genetic and enviromental disruption of testicular function
Olle Söder
Olle Söder
YB2.2
Fri 02 09:15 Yearbook of Paediatric Endocrinology
Reproductive Endocrinology
Peter Hindmarsh
Peter Hindmarsh
MTE5.1
Fri 02 08:00 Meet the Expert Sessions
Management of the adolescent with CAH
Peter Hindmarsh
Peter Hindmarsh
MTE5.2
Sat 03 15:30 Meet the Expert Sessions
Management of the adolescent with CAH
David Dunger
David Dunger
S6.2
Fri 02 14:30 Symposium 6 - Type 2 Diabetes & Obesity
New and old drugs for treatment of type 2 diabetes in children
Renuka Dias
Renuka Dias
FC3.4
Fri 02 09:15 Free Communications 3 - Diabetes
Wolfram syndrome: natural history and genotype-phenotype correlation based on EURO-WABB Registry show gender differences in disease severity
Sophie Christin-Maitre
Sophie Christin-Maitre
MTE4.1
Thu 01 16:00 Meet the Expert Sessions
Use of hormone replacement in females with endocrine disorders
Sophie Christin-Maitre
Sophie Christin-Maitre
MTE4.2
Sat 03 08:00 Meet the Expert Sessions
Use of hormone replacement in females with endocrine disorders
Revital Nimri
Revital Nimri
WG2.4
Thu 01 08:00 Working Group WG2 - ESPE Working Group on Diabetes Technology and Therapeutics
Debate: Blood glucose monitoring - which is the better: continuous real-time or episodic real-time on demand?
Heiko Krude
Heiko Krude
S4.1
Thu 01 14:00 Symposium 4 - Management of thyroid disorders: Current best practice
Screening, diagnosis and management of congenital hypothyroidism
Aneta Gawlik
Aneta Gawlik
FC12.3
Sat 03 12:30 Free Communications 12 - Obesity clinical
Re-classification of childhood obesity by steroid metabolomic disease signature
Peter Bang
Peter Bang
FC7.1
Sat 03 09:15 Free Communications 7 - Growth promoting therapies
Safety and effectiveness of Increlex® therapy in children with Laron syndrome and enrolled in the European Increlex® Growth Forum Database (EU-IGFD) in Europe
Gili Hart
Gili Hart
FC7.6
Sat 03 09:15 Free Communications 7 - Growth promoting therapies
Pharmacokinetic (PK) and pharmacodynamics (PD) modelling of MOD 4023 (a long-acting human growth hormone (hGH)) in growth hormone deficient (GHD) children
Lucy Shapiro
Lucy Shapiro
FC5.3
Fri 02 09:15 Free Communications 5 - Endocrine Oncology / Turner Syndrome
Screening in children with Succinate dehydrogenase B (SDHB) mutations: a single centre’s family clinic experience
Annalisa Deodati
Annalisa Deodati
FC14.5
Sat 03 12:30 Free Communications 14 - Puberty
Polybrominated diphenyl ethers (PBDEs) and timing of puberty in girls
Peter Kühnen
Peter Kühnen
FC12.4
Sat 03 12:30 Free Communications 12 - Obesity clinical
RM-493, a melanocortin-4 receptor (MC4R) agonist, is being therapeutically evaluated in patients with deficiencies in the Leptin – Proopiomelanocortin (POMC) – MC4R hypothalamic pathway, including Prader-Willi syndrome (PWS)
Jeffery Baron
Jeffery Baron
WG1.1
Thu 01 08:00 Working Group WG1 - ESPE Bone and Growth Plate (BGP) Working Group
Short stature: blame the chondrocyte
Francesco Luca
Francesco Luca
WG1.2
Thu 01 08:00 Working Group WG1 - ESPE Bone and Growth Plate (BGP) Working Group
The role of NFkB in growth plate chondrogenesis
Francesco Luca
Francesco Luca
S10.1
Sat 03 15:30 Symposium 10 - Growth plate & nutrition
Molecular mechanisms of growth plate adaptation during undernutrition
Nadja Fratzl-Zelman
Nadja Fratzl-Zelman
WG1.4
Thu 01 08:00 Working Group WG1 - ESPE Bone and Growth Plate (BGP) Working Group
Bone tissue characteristics in pediatric bone disease
Maria Bianchi
Maria Bianchi
WG1.5
Thu 01 08:00 Working Group WG1 - ESPE Bone and Growth Plate (BGP) Working Group
Fracture prevention in cystic fibrosis
Paolo Pozzilli
Paolo Pozzilli
WG2.1
Thu 01 08:00 Working Group WG2 - ESPE Working Group on Diabetes Technology and Therapeutics
New technologies in treating patients with type 2 diabetes
Thomas Inge
Thomas Inge
WG2.7
Thu 01 08:00 Working Group WG2 - ESPE Working Group on Diabetes Technology and Therapeutics
The rationale and potential role of surgery in the treatment of adolescent diabetes
Arianne Dessens
Arianne Dessens
WG3.2
Thu 01 08:00 Working Group WG3 - ESPE Working Group on Disorders of Sex Development (DSD)
DSD in Indonesia: the course of psychological development in late identified patients
Birgit Köhler
Birgit Köhler
WG3.5
Thu 01 08:00 Working Group WG3 - ESPE Working Group on Disorders of Sex Development (DSD)
EU-Study: dsd-LIFE
Christoffer Clemmensen
Christoffer Clemmensen
WG4.2
Thu 01 08:00 Working Group WG4 - ESPE Obesity Working Group (OWG)
A monomeric peptide triagonist for the treatment of obesity and diabetes
Luis Pérez-Jurado
Luis Pérez-Jurado
WG4.3
Thu 01 08:00 Working Group WG4 - ESPE Obesity Working Group (OWG)
Genetic approach to understanding severe early-onset childhood obesity
José Ordovás
José Ordovás
WG4.4
Thu 01 08:00 Working Group WG4 - ESPE Obesity Working Group (OWG)
Understanding gene-diet interactions as an approach for the treatment of obesity
José Ordovás
José Ordovás
S6.1
Fri 02 14:30 Symposium 6 - Type 2 Diabetes & Obesity
Can genotype be used to tailor treatment of obesity?
Charles Sklar
Charles Sklar
WG5.1
Thu 01 08:00 Working Group WG5 - ESPE Working Group on Paediatric and Adolescent Gynaecology (PAG)
Impact of malignancies and their treatment on reproductive function in girls
Charles Sklar
Charles Sklar
MTE7.1
Fri 02 08:00 Meet the Expert Sessions
Management of late-effects in the child/adolescent with cancer
Charles Sklar
Charles Sklar
MTE7.2
Sat 03 08:00 Meet the Expert Sessions
Management of late-effects in the child/adolescent with cancer
Michaël Grynberg
Michaël Grynberg
WG5.2
Thu 01 08:00 Working Group WG5 - ESPE Working Group on Paediatric and Adolescent Gynaecology (PAG)
Preservation of fertility pre-therapy
Jacques Donnez
Jacques Donnez
WG5.3
Thu 01 08:00 Working Group WG5 - ESPE Working Group on Paediatric and Adolescent Gynaecology (PAG)
Restoration of fertility in cancer adolescents after chemotherapy
Patrick Puttemans
Patrick Puttemans
WG5.4
Thu 01 08:00 Working Group WG5 - ESPE Working Group on Paediatric and Adolescent Gynaecology (PAG)
Diagnosis and management of endometriosis in adolescence
Mats Brännström
Mats Brännström
WG5.5
Thu 01 08:00 Working Group WG5 - ESPE Working Group on Paediatric and Adolescent Gynaecology (PAG)
Uterus transplantation with live births – an update
Berit Kriström
Berit Kriström
Thu 01 08:00 Working Group WG6 - ESPE Working Group on Turner Syndrome (TS)
Welcome
Berit Kriström
Berit Kriström
WG6.3
Thu 01 08:00 Working Group WG6 - ESPE Working Group on Turner Syndrome (TS)
Impact of age at start and GH dose for height gain and age at adult height in TS girls
Jacqueline Pieters
Jacqueline Pieters
WG6.1
Thu 01 08:00 Working Group WG6 - ESPE Working Group on Turner Syndrome (TS)
Incidental prenatal diagnosis of Turner Syndrome, perspectives of parents and professionals
Maura Foresti
Maura Foresti
WG6.2
Thu 01 08:00 Working Group WG6 - ESPE Working Group on Turner Syndrome (TS)
The challenges of prenatal diagnosis: the experience of a supportive group for parents of children with TS
Marian Rewers
Marian Rewers
PL1
Thu 01 11:30 Plenary 1
Genetic and environmental determinants of type 1 diabetes
Joanne Rovet
Joanne Rovet
S1.1
Thu 01 14:00 Symposium 1 - The effect of hormonal abnormalities on Neurocognition
The effect of thyroid hormones on the brain
Fergus Cameron
Fergus Cameron
S1.2
Thu 01 14:00 Symposium 1 - The effect of hormonal abnormalities on Neurocognition
The effect of diabetes mellitus on neurocognition
Alfhild Grönbladh
Alfhild Grönbladh
S1.3
Thu 01 14:00 Symposium 1 - The effect of hormonal abnormalities on Neurocognition
The effects of growth hormone and anabolic androgenic steroids on the brain
Sven Enerbäck
Sven Enerbäck
S2.1
Thu 01 14:00 Symposium 2 - Adipose tissue: Beyond classical concepts
Brown adipose tissue and its therapeutic potential
Vicente Gilsanz
Vicente Gilsanz
S2.2
Thu 01 14:00 Symposium 2 - Adipose tissue: Beyond classical concepts
Is brown adipose tissue relevant to paediatrics?
Corinne Vigouroux
Corinne Vigouroux
S2.3
Thu 01 14:00 Symposium 2 - Adipose tissue: Beyond classical concepts
Lipodystrophies: new approaches for diagnostic workup and treatment
David Sandberg
David Sandberg
S3.2
Thu 01 14:00 Symposium 3 - Disorders of sex development: An update
Decision Making in DSD: Development of a Decision Support Tool.
Scott Rivkees
Scott Rivkees
S4.2
Thu 01 14:00 Symposium 4 - Management of thyroid disorders: Current best practice
Management of hyperthyroidism in children
Scott Rivkees
Scott Rivkees
SS1.6
Fri 02 14:30 Special Symposium - Recommendations for surveillance for thyroid cancer in survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Pro - Con Debate: Arguments in favour of screening survivors at risk with thyroid ultrasound
Jose Moreno
Jose Moreno
S4.3
Thu 01 14:00 Symposium 4 - Management of thyroid disorders: Current best practice
Genetics of congenital hypothyroidism and associated problems
Thomas Inge
Thomas Inge
Thu 01 16:00 Controversies 1: Debate - Is bariatric surgery the management of choice for obese adolescents?
For the Motion
Svetlana Lajic
Svetlana Lajic
Fri 02 14:30 Controversies 2: Debate - Should pre-natal treatment for CAH be offered?
Against the Motion
Marcelo Cavalcanti
Marcelo Cavalcanti
FC1.2
Fri 02 09:15 Free Communications 1 - Adrenal
Involvement of the Wnt/beta-catenin pathway, SF1, DAX1 and stem/progenitor cell markers in paediatric adrenocortical tumors (ACTs)
Andrea Vecchiola
Andrea Vecchiola
FC1.3
Fri 02 09:15 Free Communications 1 - Adrenal
Aldosterone and mineralocorticoid receptor as inducers of immune markers in peripheral blood mononuclear cells: beyond elevating blood pressure
Bologna, Italy
Bologna, Italy
FC1.4
Fri 02 09:15 Free Communications 1 - Adrenal
Congenital adrenal hyperplasia due to 21 OH deficiency: final height before and after newborn screening era in Emilia-Romagna region, Italy
Louise Metherell
Louise Metherell
FC1.5
Fri 02 09:15 Free Communications 1 - Adrenal
Atypical presentation of six patients with mutations in the side chain cleavage enzyme CYP11A1
Maria New
Maria New
FC1.6
Fri 02 09:15 Free Communications 1 - Adrenal
An update on noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free foetal DNA in maternal plasma
Karen Heath
Karen Heath
FC2.3
Fri 02 09:15 Free Communications 2 - Bone & Mineral Metabolism
High success of a next generation sequencing panel for the molecular diagnosis of rare skeletal dysplasias
Katherine Madson
Katherine Madson
FC2.4
Fri 02 09:15 Free Communications 2 - Bone & Mineral Metabolism
Asfotase alfa: sustained efficacy and tolerability in children with hypophosphatasia treated for 5 years
Paul Dimitri
Paul Dimitri
FC2.6
Fri 02 09:15 Free Communications 2 - Bone & Mineral Metabolism
A contextual feature-based recognition approach to quantify trabecular microstructure using 1.5T axial-MRI: an innovative methodology
Elisa Corritore
Elisa Corritore
FC3.1
Fri 02 09:15 Free Communications 3 - Diabetes
RNA-based MAFA over-expression is sufficient to drive human pancreatic duct-derived cells toward a -cell-like phenotype
Yulia Tikhonvich
Yulia Tikhonvich
FC3.2
Fri 02 09:15 Free Communications 3 - Diabetes
Experience with molecular diagnosis in 48 cases of neonatal diabetes mellitus using targeted next-generation sequencing
Maria Xatzipsalti
Maria Xatzipsalti
FC3.5
Fri 02 09:15 Free Communications 3 - Diabetes
C-peptide levels and glycemic control in children, adolescents and young adults with type 1 diabetes (TID)
Ediz Yesilkaya
Ediz Yesilkaya
FC3.6
Fri 02 09:15 Free Communications 3 - Diabetes
First report of nationwide incidence and prevalence of type 1 diabetes among children in Turkey
Evelien Pease-Gevers
Evelien Pease-Gevers
FC4.1
Fri 02 09:15 Free Communications 4 - Growth
Heterozygous dominant negative STAT5B variants associated with short stature and GH insensitivity
Philip Murray
Philip Murray
FC4.2
Fri 02 09:15 Free Communications 4 - Growth
A recurrent homozygous NDUFB3 mutation, p.Trp22Arg causes a short stature disorder and mitochondrial protein complex I deficiency with a variable metabolic phenotype
Emma-Jane Gault
Emma-Jane Gault
FC4.3
Fri 02 09:15 Free Communications 4 - Growth
An updated and final analysis of a randomised placebo-controlled trial of the effect of oxandrolone and timing of pubertal induction on final height in Turner syndrome
Maria Mileta
Maria Mileta
FC4.4
Fri 02 09:15 Free Communications 4 - Growth
Modulation of GH-1 splicing as potential strategy to rescue growth hormone deficiency type II
Antti Saari
Antti Saari
FC4.5
Fri 02 09:15 Free Communications 4 - Growth
Stunted growth after inhaled corticosteroid use during the first 24 months of life
Emelie Benyi
Emelie Benyi
FC4.6
Fri 02 09:15 Free Communications 4 - Growth
Positive association between height and cancer in the Swedish population
Jenny Leipert
Jenny Leipert
FC5.1
Fri 02 09:15 Free Communications 5 - Endocrine Oncology / Turner Syndrome
Resveratrol potentiates growth inhibitory effects of rapamycin in PTEN-deficient lipoma cells by suppressing p70S6 kinase activity
Marlies Kempers
Marlies Kempers
FC5.2
Fri 02 09:15 Free Communications 5 - Endocrine Oncology / Turner Syndrome
MEN1 syndrome because of combined germline and somatic mosaicism, with important consequences for relatives
Delphine Zenaty
Delphine Zenaty
FC5.4
Fri 02 09:15 Free Communications 5 - Endocrine Oncology / Turner Syndrome
X chromosome gene dosage and the risk of developing congenital and acquired traits in Turner syndrome: a cross-sectional database analysis of the French national rare disease network
Judith Stoklasova
Judith Stoklasova
FC5.5
Fri 02 09:15 Free Communications 5 - Endocrine Oncology / Turner Syndrome
Hereditary Turner syndrome 46,X,rec(X)inv(p21q28) in six women and four generations: estimation of skeletal effects of growth hormone treatment
Rasha Hamza
Rasha Hamza
FC5.6
Fri 02 09:15 Free Communications 5 - Endocrine Oncology / Turner Syndrome
Anti-Müllerian hormone levels in patients with Turner syndrome: relation to karyotype, pubertal development and growth hormone therapy
Didier Stainier
Didier Stainier
NP1.1
Fri 02 09:15 New Perspectives Session 1
Pancreatic development using zebrafish as a model
Carles Lalueza-Fox
Carles Lalueza-Fox
PL3
Fri 02 10:45 Plenary 3
New advances in human evolution from the analysis of ancient genomes
Alan Templeton
Alan Templeton
PL4
Fri 02 12:15 Plenary 4
Genomic diversity in present day humans: Evolutionary aspects
Wendy Schwarz
Wendy Schwarz
WG7.1
Fri 02 14:15 ESPE Working Group for Paediatic Endocrine Nurse Specialists and Allied Health Professionals (PENSWG)
Nurse run short stature screening clinic
Irena Hozjan
Irena Hozjan
WG7.2
Fri 02 14:15 ESPE Working Group for Paediatic Endocrine Nurse Specialists and Allied Health Professionals (PENSWG)
Quality management initiatives in pediatric endocrinology: Selected case study and clinical initiatives
Viviane Crommert
Viviane Crommert
WG7.3
Fri 02 14:15 ESPE Working Group for Paediatic Endocrine Nurse Specialists and Allied Health Professionals (PENSWG)
Getting a patient off of medication due to coaching and care. A case report
Jan Foote
Jan Foote
WG7.4
Fri 02 14:15 ESPE Working Group for Paediatic Endocrine Nurse Specialists and Allied Health Professionals (PENSWG)
Long-term outcome of a male preschooler treated for central precocious puberty
Nicole Kirouac
Nicole Kirouac
WG7.5
Fri 02 14:15 ESPE Working Group for Paediatic Endocrine Nurse Specialists and Allied Health Professionals (PENSWG)
Pan-Canadian experience of pediatric endocrine nurses assisting youth through gender transition
Christine Davies
Christine Davies
WG7.6
Fri 02 14:15 ESPE Working Group for Paediatic Endocrine Nurse Specialists and Allied Health Professionals (PENSWG)
Sharing Resources:  Hypothyroidism 
Deborah Sloboda
Deborah Sloboda
S5.1
Fri 02 14:30 Symposium 5 - Developmental Programming: Novel concepts
Developmental programming of reproductive function: Early life nutritional impacts
Mary Patti
Mary Patti
S5.3
Fri 02 14:30 Symposium 5 - Developmental Programming: Novel concepts
Intergenerational programming of metabolic disease
Claire Bouvattier
Claire Bouvattier
S7.1
Fri 02 14:30 Symposium 7 - Hypogonadotropic hypogonadism: diagnostic and therapeutic approach
Early therapeutic approach to the male patient with HH
Véronique Tardy-Guidollet
Véronique Tardy-Guidollet
Fri 02 14:30 Controversies 2: Debate - Should pre-natal treatment for CAH be offered?
For the Motion
Dr endocrinologist,
Dr endocrinologist,
SS1.1
Fri 02 14:30 Special Symposium - Recommendations for surveillance for thyroid cancer in survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Introduction of the IGHG-thyroid group, its members and aims
Drs recommendation,
Drs recommendation,
SS1.2
Fri 02 14:30 Special Symposium - Recommendations for surveillance for thyroid cancer in survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Methodology of the IGHG recommendations
Dr endocrinologist,
Dr endocrinologist,
SS1.3
Fri 02 14:30 Special Symposium - Recommendations for surveillance for thyroid cancer in survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Which cancer survivors are at risk for thyroid cancer; summary of the evidence
Drs Clement,
Drs Clement,
SS1.4
Fri 02 14:30 Special Symposium - Recommendations for surveillance for thyroid cancer in survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Is detection of thyroid cancer in an early stage beneficial ?
Dr Goldfarb
Dr Goldfarb
SS1.5
Fri 02 14:30 Special Symposium - Recommendations for surveillance for thyroid cancer in survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Which evaluation modality is most sensitive and specific for detecting thyroid carcinoma in an early stage; summary of the evidence and decision tree analysis.
Dr Frey,
Dr Frey,
SS1.6
Fri 02 14:30 Special Symposium - Recommendations for surveillance for thyroid cancer in survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Pro-Con debate - Arguments in favour of screening survivors at risk with palpation of the neck
HM Santen
HM Santen
SS1.7
Fri 02 14:30 Special Symposium - Recommendations for surveillance for thyroid cancer in survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Further steps of the IGHG group; forming a decision aid.
Suzanne Hill
Suzanne Hill
SS2.1
Fri 02 14:30 Special Symposium - Opportunities and challenges in accessing essential medications in low and middle income countries
Facilitating Access to Essential Medicines: role of WHO
Avinash Shejale
Avinash Shejale
SS2.2
Fri 02 14:30 Special Symposium - Opportunities and challenges in accessing essential medications in low and middle income countries
Bringing essential medicines into low income countries: opportunities and challenges for the pharmaceutical
Marcel Karperien
Marcel Karperien
NP2.1
Sat 03 09:15 New Perspectives Session 2
Engineering cartilage
Julie Chowen
Julie Chowen
NP2.2
Sat 03 09:15 New Perspectives Session 2
Astrocytes and neuroendocrine control
Chris Clark
Chris Clark
NT1
Sat 03 09:15 New Technologies Session
New technologies in imaging
Tim Hubbard
Tim Hubbard
NT2
Sat 03 09:15 New Technologies Session
Next Generation Sequencing: Implementing the 100,000 genome project for treatment of NHS patients
Sandra Rojo
Sandra Rojo
FC6.2
Sat 03 09:15 Free Communications 6 - Gonads & DSD
A role for DMRT1 in human primary sex-determination
Nesa May
Nesa May
FC6.3
Sat 03 09:15 Free Communications 6 - Gonads & DSD
Establishing the role of the steroid backdoor pathway for androgen biosynthesis in the human ovary
Wassim Eid
Wassim Eid
FC6.4
Sat 03 09:15 Free Communications 6 - Gonads & DSD
Severe 46, XY disorder of sex development (DSD) due to CBX2 isoform 2 mutation is distinct from CBX2.1 deficiency and is likely due to EMX2 dysregulation in the human developing gonad
Rafael Batista
Rafael Batista
FC6.5
Sat 03 09:15 Free Communications 6 - Gonads & DSD
Characterisation of mutations in the androgen receptor (AR) identified in 38 Brazilian families with complete or partial androgen insensitivity syndrome (AIS)
Saduf Chaudhry
Saduf Chaudhry
FC6.6
Sat 03 09:15 Free Communications 6 - Gonads & DSD
Frequency of gonadal tumour in complete androgen insensitivity syndrome (CAIS): a retrospective case-series analysis
Stephen Hsu
Stephen Hsu
FC7.2
Sat 03 09:15 Free Communications 7 - Growth promoting therapies
Topicon™ ThermoMatrix™-mediated passive transdermal delivery of insulin-like growth factor 1 (IGF-1) Across EpidermFT™ full-thickness human skin equivalent (HSE): towards an extended-wear IGF-1 Patch
Stephen Hsu
Stephen Hsu
FC-LB-3
Sat 03 12:30 Free Communications 15 - Late Breaking
Pharmacokinetic and Pharmacodynamic Studies of Topicon™-Mediated Patch Delivery of Insulin Glargine in a Streptozotocin-Induced Hairless Rat Model
Nienke Bakker
Nienke Bakker
FC7.3
Sat 03 09:15 Free Communications 7 - Growth promoting therapies
IGF-I levels, complex formation and igf-bioactivity in growth hormone treated children with Prader-Willi syndrome
Gemma Carreras-Badosa
Gemma Carreras-Badosa
FC8.1
Sat 03 09:15 Free Communications 8 - Obesity Basic
DLK1 expression in adipose tissue following fetal growth restriction: relation to visceral fat expansion and catch-up growth in Wistar rats
Alexia Karvela
Alexia Karvela
FC8.2
Sat 03 09:15 Free Communications 8 - Obesity Basic
Apoptosis inhibitor of macrophages (AIM): an anti-inflammatory adipocyte factor in mild adolescent obesity?
Christian Roth
Christian Roth
FC8.3
Sat 03 09:15 Free Communications 8 - Obesity Basic
Testing the Appetite Suppressing Effects of Vitamin B12 Conjugates of Peptide YY
Eun Lee
Eun Lee
FC8.6
Sat 03 09:15 Free Communications 8 - Obesity Basic
Metabolic effects of ADP355, protein-based adiponectin receptor agonist, on mice with high-fat diet induced fatty liver disease
Bing Han
Bing Han
FC9.1
Sat 03 09:15 Free Communications 9 - Beta cell disorders
Islet δ-cells contribute to the pathobiology of atypical congenital hyperinsulinism
Bing Han
Bing Han
FC9.3
Sat 03 09:15 Free Communications 9 - Beta cell disorders
Failure to terminate cell proliferation contributes to the pathobiology of congenital hyperinsulinism in infancy
Sophie Kellaway
Sophie Kellaway
FC9.2
Sat 03 09:15 Free Communications 9 - Beta cell disorders
A novel source of mesenchymal stem cells lines from the human neonatal pancreas of patients with congenital hyperinsulinism in infancy
Azizun Nessa
Azizun Nessa
FC9.4
Sat 03 09:15 Free Communications 9 - Beta cell disorders
Novel molecular mechanisms of congenital hyperinsulinism due to autosomal dominant mutations in ABCC8
Chao Zou
Chao Zou
FC10.1
Sat 03 12:30 Free Communications 10 - Perinatal endocrinology
Effect of sonic hedgehog signalling on regulation the expression of 11β-HSD2 in the placenta
Josephina Hollanders
Josephina Hollanders
FC10.5
Sat 03 12:30 Free Communications 10 - Perinatal endocrinology
Lack of association between transient hypothyroxinaemia of prematurity and neurodevelopmental and behavioral outcomes in young adulthood
Tohru Yorifuji
Tohru Yorifuji
FC10.6
Sat 03 12:30 Free Communications 10 - Perinatal endocrinology
Heterozygous hypomorphic mutation in the INS gene could cause transient neonatal diabetes in extremely low birth weight neonates
Marie-Laure Sobrier
Marie-Laure Sobrier
FC11.2
Sat 03 12:30 Free Communications 11 - Neuroendocrinology
Functional characterisation of a POU1F1 mutation unexpectedly associated with isolated growth hormone deficiency (IGHD): a novel aetiology of IGHD
Mark McCabe
Mark McCabe
FC11.3
Sat 03 12:30 Free Communications 11 - Neuroendocrinology
Next generation sequencing: towards a new clinical frontier in the diagnosis and management of pituitary tumours
Nimasari Ginige
Nimasari Ginige
FC11.4
Sat 03 12:30 Free Communications 11 - Neuroendocrinology
Idiopathic multiple pituitary hormone deficiency (IMPHD): radiological and perinatal factors
Eftychia Dimitrakopoulou
Eftychia Dimitrakopoulou
FC11.5
Sat 03 12:30 Free Communications 11 - Neuroendocrinology
Endocrinopathy after intracranial germ cell tumours (IGCT) is disease not radiation- related: two decades of surveillance in a large tertiary paediatric cohort
Galina Yordanova
Galina Yordanova
FC11.6
Sat 03 12:30 Free Communications 11 - Neuroendocrinology
Long-term outcome of patients treated for paediatric Cushing's disease
Gemma Carreras-Baosa
Gemma Carreras-Baosa
FC12.2
Sat 03 12:30 Free Communications 12 - Obesity clinical
Soluble CD163, a circulating marker of macrophage activation, associates with a less favourable metabolic profile in children
Swathi Upadrasta
Swathi Upadrasta
FC12.5
Sat 03 12:30 Free Communications 12 - Obesity clinical
Link between body mass index and insulin requirement in children and young people with type 1 diabetes mellitus
Hana Sediva
Hana Sediva
FC13.1
Sat 03 12:30 Free Communications 13 - Thyroid
Gain of function STAT3 mutation in a boy with early onset autoimmune diabetes and thyroid disease, prenatal and postnatal growth impairment and lymphoproliferation
Aleksandra Goralczyk
Aleksandra Goralczyk
FC13.2
Sat 03 12:30 Free Communications 13 - Thyroid
Analysis of chosen polymorphisms rs2476601 A/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 A/G - TSHR in pathogenesis of autoimmune thyroid diseases in children
Nina Makretskaya
Nina Makretskaya
FC13.3
Sat 03 12:30 Free Communications 13 - Thyroid
Targeted next-generation sequencing demonstrates high frequency of ‘dyshormonogenesis genes’ mutations in severe congenital hypothyroidism
Andrea Esposito
Andrea Esposito
FC13.4
Sat 03 12:30 Free Communications 13 - Thyroid
Effects of initial levothyroxine dose on growth and neurodevelopmental outcomes during the first year of life in children with congenital hypothyroidism
A Iglesias
A Iglesias
FC13.6
Sat 03 12:30 Free Communications 13 - Thyroid
TRIAC treatment of allan-herndon-dudley syndrome (AHDS) due to defects in thyroid hormone transporter MCT8
Cheng Xu
Cheng Xu
FC14.1
Sat 03 12:30 Free Communications 14 - Puberty
KLB, encoding the co-receptor for FGF21, is mutated in congenital hypogonadotropic hypogonadism
Eli Hershkovitz
Eli Hershkovitz
FC14.3
Sat 03 12:30 Free Communications 14 - Puberty
The new syndrome of hypogonadotropic hypogonadism, arrythmogenic right ventricular dysplasia, facial dysmorphism and absence of corpus callosum is associated to TAX1 binding protein 3 gene mutation
Casper Hagen
Casper Hagen
FC14.4
Sat 03 12:30 Free Communications 14 - Puberty
Genetic variation of AMH signaling affects AMH and inhibin B levels in healthy peripubertal girls
Louise Fugl
Louise Fugl
FC14.6
Sat 03 12:30 Free Communications 14 - Puberty
An evaluation of glandular breast tissue development and volume by MRI in 121 healthy peripubertal girls
Carole Harbulot
Carole Harbulot
FC-LB-2
Sat 03 12:30 Free Communications 15 - Late Breaking
Loss of Neuronal Dmxl2 impairs the maturation and the activation of GnRH neurons: a new mechanism of GnRH deficiency.
Lena Wallensteen
Lena Wallensteen
FC-LB-4
Sat 03 12:30 Free Communications 15 - Late Breaking
Long-term cognitive effects of antenatal dexamethasone treatment in Swedish adolescents with and without CAH
Gerhard Binder
Gerhard Binder
FC-LB-5
Sat 03 12:30 Free Communications 15 - Late Breaking
Paternally inherited IGF2 mutation results in intrauterine and postnatal growth retardation
Maria Millan
Maria Millan
FC-LB-6
Sat 03 12:30 Free Communications 15 - Late Breaking
PROP1 mutations cause hypopituitarism by disrupting the transition of pituitary stem cells to differentiation
Oluf Pedersen
Oluf Pedersen
S8.1
Sat 03 15:30 Symposium 8 - Diabetes & Obesity as infectious diseases
Disentangling disease and drug signatures in the human gut microbiome
Rémy Burcelin
Rémy Burcelin
S8.2
Sat 03 15:30 Symposium 8 - Diabetes & Obesity as infectious diseases
The role of the gut microbiome for immunity and metabolism
Ondrej Cinek
Ondrej Cinek
S8.3
Sat 03 15:30 Symposium 8 - Diabetes & Obesity as infectious diseases
Gut microbiome modulates the risk for islet autoimmunity
Hermann Mueller
Hermann Mueller
S9.1
Sat 03 15:30 Symposium 9 - Childhood Craniopharyngioma: Recent Advances
Outcomes in patients with childhood craniopharyngioma
Michael Buchfelder
Michael Buchfelder
S9.2
Sat 03 15:30 Symposium 9 - Childhood Craniopharyngioma: Recent Advances
Surgical approach to craniopharyngioma
Lars	Sävendahl
Lars Sävendahl
S10.2
Sat 03 15:30 Symposium 10 - Growth plate & nutrition
Molecular response of the growth plate to inflammatory cytokines
Pinchas Cohen
Pinchas Cohen
PL6
Sat 03 17:45 Plenary 6
The complex relationship between the GH/IGF axis and aging and longevity – the interface with diet and mitochondrial peptides
Constantine Stratakis
Constantine Stratakis
MTE1.1
Thu 01 16:00 Meet the Expert Sessions
Management of adrenal tumours
Constantine Stratakis
Constantine Stratakis
MTE1.2
Sat 03 08:00 Meet the Expert Sessions
Management of adrenal tumours
John Achermann
John Achermann
FC1.1
Fri 02 09:15 Free Communications 1 - Adrenal
A genomic atlas of human gonad and adrenal development
Outi Mäkitie
Outi Mäkitie
YB3.3
Sat 03 12:30 Yearbook of Paediatric Endocrinology
Bone, Growth plate and mineral metabolism
Sasha Howard
Sasha Howard
FC14.2
Sat 03 12:30 Free Communications 14 - Puberty
A mutation in HS6ST1 causes self-limited delayed puberty
Rachel Besser
Rachel Besser
FC11.1
Sat 03 12:30 Free Communications 11 - Neuroendocrinology
Mutations in BRAF are associated with septo-optic dysplasia and cardiofaciocutaneous syndrome
Jarod Wong
Jarod Wong
S10.3
Sat 03 15:30 Symposium 10 - Growth plate & nutrition
Bone health in chronic disease
Thomas Reinehr
Thomas Reinehr
WG2.6
Thu 01 08:00 Working Group WG2 - ESPE Working Group on Diabetes Technology and Therapeutics
Type 2 diabetes mellitus in adolescence
Thomas Reinehr
Thomas Reinehr
Thu 01 16:00 Controversies 1: Debate - Is bariatric surgery the management of choice for obese adolescents?
Against the Motion
Christa Flück
Christa Flück
WG3.1
Thu 01 08:00 Working Group WG3 - ESPE Working Group on Disorders of Sex Development (DSD)
Maternal, placental and fetal steroid hormone synthesis: the key facts for understanding DSDs
Nadine Hornig
Nadine Hornig
FC6.1
Sat 03 09:15 Free Communications 6 - Gonads & DSD
Correlation of AR expression and AR transcriptional activity in cultured human genital fibroblasts
Klaus Mohnike
Klaus Mohnike
FC9.5
Sat 03 09:15 Free Communications 9 - Beta cell disorders
The use of glucagon for management of severe-persistent hypoglycaemia in patients with congenital hyperinsulinism
Moshe Phillip
Moshe Phillip
Thu 01 08:00 Working Group WG2 - ESPE Working Group on Diabetes Technology and Therapeutics
Introductions
Moshe Phillip
Moshe Phillip
WG2.3
Thu 01 08:00 Working Group WG2 - ESPE Working Group on Diabetes Technology and Therapeutics
Debate: Are genetic tests necessary before starting a treatment of a patient with Neonatal Diabetes?
Jacques Beltrand
Jacques Beltrand
FC9.6
Sat 03 09:15 Free Communications 9 - Beta cell disorders
Pharmacokinetics (PK) of a new suspension of glibenclamide for use in young patients and infants with neonatal diabetes
Tadej Battelino
Tadej Battelino
FC7.4
Sat 03 09:15 Free Communications 7 - Growth promoting therapies
A novel reversible albumin-binding growth hormone derivative possesses a promising once-weekly treatment profile in children with growth hormone deficiency
Malcolm Donaldson
Malcolm Donaldson
WG6.4
Thu 01 08:00 Working Group WG6 - ESPE Working Group on Turner Syndrome (TS)
Management of middle ear and hearing problems in Turner's syndrome - how can we do better?
Anna Nordenström
Anna Nordenström
Thu 01 08:00 Working Group WG3 - ESPE Working Group on Disorders of Sex Development (DSD)
Welcome
Anna Nordenström
Anna Nordenström
Thu 01 08:00 Working Group WG3 - ESPE Working Group on Disorders of Sex Development (DSD)
DSD Open Business Meeting
Maithé Tauber
Maithé Tauber
MTE6.1
Fri 02 08:00 Meet the Expert Sessions
Management of Prader-Willi syndrome in toddlers
Maithé Tauber
Maithé Tauber
MTE6.2
Sat 03 15:30 Meet the Expert Sessions
Management of Prader-Willi syndrome in toddlers
Wolfgang Högler
Wolfgang Högler
MTE8.1
Fri 02 08:00 Meet the Expert Sessions
Looking beyond nutritional rickets: From the foetus to the infant
Wolfgang Högler
Wolfgang Högler
MTE8.2
Sat 03 15:30 Meet the Expert Sessions
Looking beyond nutritional rickets: From the foetus to the infant
Theo Sas
Theo Sas
WG6.5
Thu 01 08:00 Working Group WG6 - ESPE Working Group on Turner Syndrome (TS)
Report on the progress and difficulties on transdermal Estradiol supplementation in Europe
Patrizia Bruzzi
Patrizia Bruzzi
FC12.1
Sat 03 12:30 Free Communications 12 - Obesity clinical
Evaluation of cardiovascular risk in childhood: data from a survey of dyslipidaemic children
Evangelia Charmandari
Evangelia Charmandari
YB3.1
Sat 03 12:30 Yearbook of Paediatric Endocrinology
Adrenals
Khalid Hussain
Khalid Hussain
YB2.3
Fri 02 09:15 Yearbook of Paediatric Endocrinology
Antenatal and Neonatal Endocrinology
Orit Pinhas-Hamiel
Orit Pinhas-Hamiel
YB1.2
Thu 01 16:00 Yearbook of Paediatric Endocrinology
Type 2 diabetes, metabolic syndrome and lipids
Ken Ong
Ken Ong
YB1.5
Thu 01 16:00 Yearbook of Paediatric Endocrinology
Editor's choice
Judit Bassols
Judit Bassols
FC10.2
Sat 03 12:30 Free Communications 10 - Perinatal endocrinology
The altered circulating miRNA profile in maternal obesity associate with pre- and post-natal growth
Judit Bassols
Judit Bassols
FC10.3
Sat 03 12:30 Free Communications 10 - Perinatal endocrinology
Circulating miRNA expression profile in pregestational and gestational obesity
Martin Wabitsch
Martin Wabitsch
YB1.1
Thu 01 16:00 Yearbook of Paediatric Endocrinology
Obesity and weight regulation
Martin Wabitsch
Martin Wabitsch
FC8.4
Sat 03 09:15 Free Communications 8 - Obesity Basic
Severe early-onset obesity caused by bioinactive leptin due to a N103K mutation
Carla Bizzarri
Carla Bizzarri
YB3.4
Sat 03 12:30 Yearbook of Paediatric Endocrinology
Oncology and chronic disease
Jean-Pierre Chanoine
Jean-Pierre Chanoine
SS2.3
Fri 02 14:30 Special Symposium - Opportunities and challenges in accessing essential medications in low and middle income countries
A model for the sustainable access to medicines for the management of congenital adrenal hyperplasia (CAH) in a low income setting
Gabor Szinnai
Gabor Szinnai
YB3.2
Sat 03 12:30 Yearbook of Paediatric Endocrinology
THyroid
Ken McElreavey
Ken McElreavey
S3.1
Thu 01 14:00 Symposium 3 - Disorders of sex development: An update
Novel genes identified in male and female sex development
Faisal Ahmed
Faisal Ahmed
WG3.4
Thu 01 08:00 Working Group WG3 - ESPE Working Group on Disorders of Sex Development (DSD)
I-DSD and I-CAH registry update
Michel Polak
Michel Polak
WG2.2
Thu 01 08:00 Working Group WG2 - ESPE Working Group on Diabetes Technology and Therapeutics
Debate: Are genetic tests necessary before starting a treatment of a patient with Neonatal Diabetes?
Wieland Kiess
Wieland Kiess
YB1.3
Thu 01 16:00 Yearbook of Paediatric Endocrinology
Type 1 diabetes
Wieland Kiess
Wieland Kiess
YB2.5
Fri 02 09:15 Yearbook of Paediatric Endocrinology
Type 1 diabetes
Jesús Argente
Jesús Argente
MTE3.1
Thu 01 16:00 Meet the Expert Sessions
Challenges in the management of short stature
Jesús Argente
Jesús Argente
MTE3.2
Sat 03 08:00 Meet the Expert Sessions
Challenges in the management of short stature
Taneli Raivio
Taneli Raivio
S7.3
Fri 02 14:30 Symposium 7 - Hypogonadotropic hypogonadism: diagnostic and therapeutic approach
Modeling GnRH deficiency with the use of human pluripotent cells
Nicolas Roux
Nicolas Roux
YB2.1
Fri 02 09:15 Yearbook of Paediatric Endocrinology
Pituitary and neuroendocrinology
Ze'ev Hochberg
Ze'ev Hochberg
YB3.5
Sat 03 12:30 Yearbook of Paediatric Endocrinology
The Year in Science and Medicine
Shaheena Parween
Shaheena Parween
FC10.4
Sat 03 12:30 Free Communications 10 - Perinatal endocrinology
Effect of P450 oxidoreductase variants on metabolism by cytochrome P450 proteins
Klemens Raile
Klemens Raile
FC3.3
Fri 02 09:15 Free Communications 3 - Diabetes
Clinical characteristics and molecular genetic analysis of 6 patients with pancreas aplasia and neonatal diabetes: predominance of PTF1A-enhancer mutations
Silva Arslanian
Silva Arslanian
S6.3
Fri 02 14:30 Symposium 6 - Type 2 Diabetes & Obesity
From obesity to type 2 diabetes
Susan Ozanne
Susan Ozanne
S5.2
Fri 02 14:30 Symposium 5 - Developmental Programming: Novel concepts
Transgenerational developmental programming of endocrine disease
Andrew Hattersley
Andrew Hattersley
PL2
Thu 01 12:00 Plenary 2
New advances in monogenetic diabetes
Eirini Meimaridou
Eirini Meimaridou
FC-LB-1
Sat 03 12:30 Free Communications 15 - Late Breaking
RNA Sequencing Reveals The Pathways Perturbed by Redox Imbalance in Nicotinamide Nucleotide Transhydrogenase null mice.
Nelly Pitteloud
Nelly Pitteloud
S7.2
Fri 02 14:30 Symposium 7 - Hypogonadotropic hypogonadism: diagnostic and therapeutic approach
Pubertal induction and fertility prospects in the male
Abstract Code Title Authors Affiliations Category
P1-1 Evaluation of Glucose Metabolism and Cardiovascular Risk Factors and Hyperandrogenemia in Prepubertal Girls with Premature Pubarche Digdem Bezen, Filiz Tutunculer, Emine Dilek, Didem Ag Seleci, Hakan Erbas Adrenals and HPA Axis
P1-10 Use of a Cord Blood F-Dex Monocyte Binding Assay to Study the Glucocorticoid Receptor in Neonates Arun Kashyap, Javier Aisenberg, Steven Ghanny Adrenals and HPA Axis
P1-100 Atypical features in patients with Leprechaunism suggesting a wide clinical spectrum of disease Harshini Katugampola, Nicola Improda, Pratik Shah, Hannah Gordon, Rakesh Amin, Catherine J Peters, Robert K Semple, Mehul T Dattani Diabetes and Insulin
P1-101 Does Type 1 childhood diabetes start in utero? Zvi Laron, Christiane Hampe, Lester Shulman Diabetes and Insulin
P1-102 The role of HNF1B in human pancreas development and diabetes Ranna El Khairi, Andrew Hattersley, Ludovic Vallier Diabetes and Insulin
P1-103 Molecular Characterization of a Novel Non-Stop KCNJ11 Mutation Associated with a Dual Focal and Diffuse Hyperinsulinaemic Hypoglycaemia Phenotype Ved Bhushan Arya, Qadeer Aziz, Sarah E. Flanagan, Sian Ellard, Andrew Tinker, Khalid Hussain Hypoglycaemia
P1-104 Diazoxide Responsive Congenital Hyperinsulinism in a Patient with Dual Genetic Aetiology (HNF4A and ABCC8 mutation) Dinesh Giri, Sarah E. Flanagan, Julie Park, Sian Ellard, Mo Didi, Senthil Sennaippan Hypoglycaemia
P1-105 Fluoxetine induced Hypoglycemia in a patient with Congenital Hyperinsulinism on Lanreotide Therapy Dinesh Giri, Zoe Yung, Kelly Stirrup, Mo Didi, Senthil Seniappan Hypoglycaemia
P1-106 Influence of nocturnal glycemia on ventricular repolarization and heart rate variability in prepubertal children with type 1 diabetes. Marie-Béatrice Saade, Aurélien Pecquet, Patrick Pladys, Alain Beuchée, Fabienne Pelé, Sylvie Nivot, Marc de Kerdanet Hypoglycaemia
P1-107 CHANGES IN SERUM PROTEIN EXPRESSION IN SMALL-FOR-GESTATIONAL-AGE NEWBORN INFANTS AT DIFFERENT GESTATIONAL AGES Ramón Cañete, María Dolores Ruiz-González, María Dolores Cañete, José Luis Gómez-Chaparro, Nieves Abril-Díaz, Juan Luis López-Barea Perinatal and Neonatal Endocrinology
P1-108 Liver ER stress and Intrauterine growth retardation in rats Annalisa Deodati, Josepmaria Argemi, Antonella Puglianiello, Daniela Germani, Roberto Ferrero, Tomas Aragon, Stefano Cianfarani Perinatal and Neonatal Endocrinology
P1-109 Continuous subcutaneous infusion of recombinant LH and FSH during early infancy promotes testicular descent in congenital hypogonadotropic hypogonadism. Anne Sophie LAMBERT, Philippe Lucchini, Claire Bouvattier, Pierre Bougnères Perinatal and Neonatal Endocrinology
P1-11 Steroid 11β-Hydroxylase Deficient Congenital Adrenal Hyperplasia with a Reversible Cardiomyopathy Caused by a Novel CYP11B1 Mutation: Report of Three Cases Mohammad Ahmad Awwad Alqahtani, Ayed A Shati, Minjing Zou, Ali M Alsuheel, Abdullah A Alhayani, Saleh M Al-Qahtani, Hessa M Gilban, Brain F Meyer, Yufei Shi Adrenals and HPA Axis
P1-110 Neonatal screening program for Central Congenital Hypothyroidism Debora Braslavsky, Laura Prieto, Ana Keselman, Laura Gruñeiro de Papendieck, Rosa Enacan, Virginia Mendez, Ignacio Bergadá, Ana Chiesa Perinatal and Neonatal Endocrinology
P1-111 Serum Neurokinin B level can be used to differentiate central precocious puberty from premature thelarche. Mesut Parlak, Doga Turkkahraman, Hamit Yasar Ellidag, Ayse Eda Parlak Puberty and Neuroendocrinology
P1-112 Etiological spectrum and clinical characteristics of 129 children with gonadotropin independent precocious puberty: A nationwide cohort study Zeynep Atay, Ediz Yeşilkaya, Senay Savas Erdeve, Leyla Akin, Erdal Eren, Esra Döger, Zehra Aycan, Zehra Yavaş Abali, Ayşehan Akinci, Zeynep Şiklar, Samim Özen, Cengiz Kara, Meltem Tayfun, Filiz Tutunculer, Gülcan Seymen Karabulut, Gülay Karagüzel, Halil Sağlam, Aysun Bideci, Selim Kurtoğlu, Abdullah Bereket, Serap Turan, Erkan Sari, Semra Çetinkaya, Tülay Güran, Turkish Peropheral Puberty Research Group Puberty and Neuroendocrinology
P1-113 Relevance of astrocytic signals for GnRH-neuronal function Johanna Ernst, Hanna Moeller, Manuel Pfeifer, Sabine Heger Puberty and Neuroendocrinology
P1-114 Screening of mutations in idiopathic hypogonadotropic hypogonadism using a targeted next-generation sequencing approach Anna Kolodkina, Maria Kareva, Natalia Kalinchenko, Nadezhda Raygorodskaya, Oleg Malievsky, Olga Fidelina, Evgeny Vasilyev, Vasily Petrov, Maria Naumova, Anatoly Tiulpakov Puberty and Neuroendocrinology
P1-115 Clinical guidance on 17β-Estradiol and LH serum levels in girls with Premature Thelarche based on clinical outcome of 129 girls aged up to 4 year with premature thelarche in West Sweden. Martin Österbrand, Kerstin Alvin, Hans Fors, Ensio Norjavaara Puberty and Neuroendocrinology
P1-116 FSHB/FSHR genetic variants alter serum FSH levels and prepubertal ovarian follicular growth in healthy girls Alexander S. Busch, Casper P. Hagen, Kristian Almstrup, Katharina M. Main, Anders Juul Puberty and Neuroendocrinology
P1-117 Transient breast budding in healthy girls is a frequent phenomenon: Description of pubertal progression and associations to gonadotropins, estradiol and FSHB/FSHR genetic polymorphisms Marie Lindhardt Johansen, Casper P. Hagen, Mikkel G. Mieritz, Jørgen Holm Petersen, Anders Juul Puberty and Neuroendocrinology
P1-118 Specific hypothalamic activation pattern by mGlu5 receptor blockade in vivo during pubertal development in female mice Ioana Inta, Roberto de Angelis, Katja Lankisch, Christof Dormann, Natascha Pfeiffer, Ulrich Boehm, Peter Gass, Markus Bettendorf Puberty and Neuroendocrinology
P1-119 Lipid profiles in gender dysphoric adolescents treated with GnRH agonists alone and in combination with cross-sex hormones Sebastian Schagen, Henriette Delemarre-van de Waal, Sabine Hannema Puberty and Neuroendocrinology
P1-12 GENETIC DIAGNOSIS USING WHOLE EXOME ANALYSIS IN TWO CASES WITH MALIGN INFANTILE OSTEOPETROSIS Korcan Demir, Özlem Nalbantoğlu, Kadri Karaer, Hüseyin Anıl Korkmaz, Melek Yıldız, Selma Tunç, Behzat Özkan Bone, Growth Plate and Mineral Metabolism
P1-120 A novel LHX4 mutation is associated with hypogonadotropic hypogonadism, not combined pituitary hormone deficiency Masaki Takagi, Takashi Daitsu, Chikahiko Numakura, Takeshi Sato, Satoshi Narumi, Tomonobu Hasegawa Puberty and Neuroendocrinology
P1-121 A missense mutation in MKRN3 in a Danish girl with central precocious puberty and her brother with early puberty Johanna Känsäkoski, Taneli Raivio, Anders Juul, Johanna Tommiska Puberty and Neuroendocrinology
P1-122 Congenital hypothyroidism in twin couples and triplets Antonella Olivieri, Giovanna Weber, Alessandra Cassio, Pietro Costa, Francesca Calaciura, Emanuela Medda, Maria Cristina Vigone, Tiziana De Filippis, Giulia Gelmini, Federica Marelli, Valeria Di Russo, Luca Persani Thyroid
P1-123 Th17 cells in children with Graves’ disease during methimazole treatment Maria Klatka, Ewelina Grywalska, Jacek Rolinski Thyroid
P1-124 Thyrocytes are particularly well protected against oxidative stress induced by H2O2 Chiraz Ghaddhab, Emmanuel Van Den Eeckhaute, Olivier Hancisse, Natacha Driessens, Jacques-Emile Dumont, Françoise Miot, Bernard Corvilain Thyroid
P1-125 Thyrocyte is particularly well protected against oxidative stress induced by H2O2 Chiraz Ghaddhab, Emmanuel Van Den Eeckhaute, Olivier Hancisse, Natacha Driessens, Soetkin Versteyhe, Françoise Miot, Jacques-Emile Dumont, Bernard Corvilain Thyroid
P1-126 Characteristics and Outcome of Neonates with Congenital Hypothyroidism Born after In Vitro Fertilisation (IVF) Vassiliki Giogli, Christina Kanaka-Gantenbein, Jessica-Debora Arditi, Dimitris Platis, George Chouliaras, Chrysoula Kourkouti, Ioanna Kosteria, Anna Gika, Alexandra Iliadi, George Chrousos, Panagiotis Girginoudis, Antonis Voutetakis Thyroid
P1-127 Transient vs. Permanent Congenital Hypothyroidism: The Use of Baseline Characteristics and Long-term Data Can Help Formulate a Practical Prognostic Algorithm Vassiliki Giogli, Christina Kanaka-Gantenbein, George Chouliaras, Jessica-Debora Arditi, Anna Gika, Alexandra Iliadi, Dimitris Platis, Eleni Magdalini Kyritsi, Petros Karkalousos, George-Albert Karikas, Chrysanthi Mengreli, George Chrousos, Panagiotis Girginoudis, Antonis Voutetakis Thyroid
P1-128 Diverse Genotypes and Phenotypes of Three Novel Thyroid Hormone Receptor Alpha Mutations Korcan Demir, Anja van Gucht, Muammer Büyükinan, Gönül Catli, Yavuz Ayhan, Veysel Nijat Bas, Bumin Nuri Dündar, Behzat Ozkan, Marcel E. Meima, W. Edward Visser, Robin P. Peeters, Theo J. Visser Thyroid
P1-129 Intelligence and behaviour in children and adolescents with Hashimoto´s thyroiditis Claudia Boettcher, Burkhard Brosig, Henriette Windhaus, Stefan A. Wudy, Andreas Hahn Thyroid
P1-13 Osteogenesis imperfecta - a pilot trial on treatment with the RANKL-antibody Denosumab Heike Hoyer-Kuhn, Christian Netzer, Barbara Hero, Eckhard Schoenau, Oliver Semler Bone, Growth Plate and Mineral Metabolism
P1-130 Brain-lung-thyroid syndrome - update on the clinical spectrum of a heterogeneous disorder Nina Lenherr, Jean-Marc Vuissoz, Karl Heinimann, Gabor Szinnai Thyroid
P1-131 Increased Detection Rate of Paired Box Domain Gene Mutations by Application of Multiplex Ligation-Dependent Probe Amplification Analysis in Patients with Primary Congenital Hypothyroidism and Thyroid Dysgenesis Malgorzata Kumorowicz-Czoch, Pia Hermanns, Anna Madetko-Talowska, Joahim Pohlenz Thyroid
P1-132 A severe hyperthyroidism in an infant revealed a familial nonautoimmune hyperthyroidism with novel heterozygous thyrotropin receptor gene mutation. Isabelle OLIVER PETIT, Frédérique SAVAGNER, Thomas EDOUARD, Philippe CARON Thyroid
P1-133 Improved determination of total serum estrogenic bioactivity: characterization of estrogenic activity modulators. Paris Françoise, Grimaldi Marina, Sultan Charles, Balaguer Patrick Gonads and Gynaecology
P1-134 Co-existing variants of FOXE1 and BMP15 genes in young females with primary ovarian insufficiency (POI): Evidence of digenic inheritance. NIKOLAOS SETTAS, LINA MICHALA, EFTHIMIOS DELIGEOROGLOU, DIONISIOS CHRYSIS, ANDREAS PAMPANOS, ELENI THEOCHARI, OLYMPIA VALLA, CHRISTALENA SOFOCLEOUS, KITSIOU SOFIA, HELEN FRYSSIRA, EMMANUEL KANAVAKIS, CATHERINE DACOU-VOUTETAKIS, GEORGE P CHROUSOS, ANTONIS VOUTETAKIS Gonads and Gynaecology
P1-135 Sex hormones and gonadal size in pubertal girls born small or appropriate for gestational age Indre Petraitiene, Rasa Verkauskiene, Kristina Jariene, Astra Vitkauskiene Gonads and Gynaecology
P1-136 The Eap1 promoter is differentially methylated at the onset of puberty in normal weight and obese female rats Hanna Moeller, Sabine Heger Puberty and Neuroendocrinology
P1-137 Normalization of puberty and adult height in girls with Turner syndrome, randomized trials versus age and dose at GH-start Berit Kriström, Carina Ankarberg-Lindgren, Marie-Louise Barrenäs, Karlolof Nilsson, Kerstin Albertsson-Wikland Turner Syndrome
P1-138 Weight gain in Turner Syndrome: Association to puberty induction? Thomas Reinehr, Anders Lindberg, Christina Toschke, Jose Cara, Dionisios Chrysis, Cecila Camacho-Hübner Turner Syndrome
P1-139 A study of arterial stiffness in Turner syndrome patients using cardio-ankle vascular index Hae Woon Jung, Hwa Young Kim, Gyung Min Lee, So Youn Kim, Kyung A Jeong, Keun Hee Choi, Jieun Lee, Young Ah Lee, Choong Ho Shin, Sei Won Yang Turner Syndrome
P1-14 No secular trend in vitamin D levels over the past 30 years in Swedish children Björn Andersson, Kerstin Albertsson-Wikland, Diana Swolin-Eide, Per Magnusson Bone, Growth Plate and Mineral Metabolism
P1-140 Impaired motor function in Turner syndrome: what is the relationship to performal intelligence scores? Betül Taskin, Chris Verhaak, Marlou Essink, Marlies Kempers, Anja Vinck, Ria Nijhuis-van der Sanden, Janiëlle van Alfen-van der Velden Turner Syndrome
P1-141 Adult height after growth hormone treatment and its association with X chromosome dosage in Turner Syndrome: a cross-sectional database analysis of the French national rare disease network. Elodie Fiot, Delphine Zenaty, Priscilla Boizeau, Jérémie Haignere, Sophie Dos Santos, Juliane Léger, French Turner Syndrome Study Group . Turner Syndrome
P1-142 Fracture incidence is not associated with the 6-year development of trabecular BMD in paediatric Turner syndrome patients Ondrej Soucek, Zdenek Sumnik, Marta Snajderova, Stanislava Kolouskova, Jan Lebl Turner Syndrome
P1-143 Is Aortic Stiffness Increased in Young Turner Syndrome Patients? Danya Fox, Kristopher Kang, Laura Stewart, Janis Dionne, James Potts, George Sandor Turner Syndrome
P1-144 Primary Adrenal Insufficiency in children without congenital adrenal hyperplasia: Molecular and clinical characterization of a nationwide cohort Tulay Guran, Federica Buonocore, Nurcin Saka, Mehmet Nuri Ozbek, Zehra Aycan, Abdullah Bereket, Firdevs Bas, Sukran Darcan, Aysun Bideci, Serap Turan, Ayla Guven, Omer Tarim, Sebahat Yilmaz Agladioglu, Zeynep Atay, Samim Ozen, Korcan Demir, Aysehan Akinci, Banu Kucukemre Aydin, Muammer Buyukinan, Bilgin Yuksel, Metin Yildiz, Teoman Akcay, Cengiz Kara, Tolga Ozgen, Gonul Catli, Emregul Isik, Semih Bolu, Bayram Ozhan, Fatih Gurbuz, Ahmet Ucar, Huseyin Demirbilek, Zehra Yavas Abali, Esra Doger, Erdal Eren, Merih Berberoglu, Bulent Hacihamdioglu, John C. Achermann Adrenals and HPA Axis
P1-145 Clinical follow-up of the first SF-1 deficient female patient Karine Gerster, Anna Biason-Lauber, Eugen J. Schoenle Adrenals and HPA Axis
P1-146 Salt sensitivity of blood pressure at age 7-8 years in preterm born children. Charlotte A. Ruys, Harrie N. Lafeber, Joost Rotteveel, Martijn J.J. Finken Miscellaneous
P1-147 A new LC-MS/MS assay for the analysis of sulfated steroids in human serum: quantification of cholesterol sulfate, pregnenolone sulfate, 17-hydroxypregnenolone sulfate and androgen sulfates Alberto Sánchez-Guijo, Vinzenz Oji, Michaela F. Hartmann, Heiko Traupe, Stefan A. Wudy Miscellaneous
P1-148 The analysis of occurrence the zinc transporter antibodies ZnT8 in children with Graves’ disease and Hashimoto’s thyroiditis. Artur Bossowski, Hanna Borysewicz-Sanczyk, Anna Bossowska, Mieczyslaw Szalecki, Anna Kucharska, Beata Pyrzak, Mieczyslaw Walczak, Elzbieta Petriczko, Katarzyna Ziora, Maria Del Pilar Larosa, Shu Chen, Michael Powell, Jadwiga Furmaniak, Bernard Rees Smith Autoimmune Endocrine Disease
P1-149 Recombinant Parathyroid Hormone (1-34) replacement treatment of Hypoparathyroidism in the alfacalcidol-resistant patient with severe Autoimmune Polyendocrinopathy Syndrome type 1 Leila Sozaeva, Elizaveta Orlova, Maria Kareva Autoimmune Endocrine Disease
P1-15 Lithium chloride prevents glucocorticoid-induced growth failure in cultured fetal rat metatarsal bones Ondrej Soucek, Farasat Zaman, Lars Sävendahl Bone, Growth Plate and Mineral Metabolism
P1-150 Severe immunodysregulation phenotypes including infancy-onset type 1 diabetes mellitus in two siblings with a homozygous mutation in the LPS-responsive beige-like anchor (LRBA) gene Felix Schreiner, Michaela Plamper, Gesche Düker, Stefan Schoenberger, Janine Altmueller, Alina Hilger, Heiko Reutter, Joachim Woelfle Autoimmune Endocrine Disease
P1-151 A case of autoimmune polyglandular syndrome type I presenting as progressive generalized lipodystrophy in a 15-month-old child. Ekaterina Sorkina, Elena Frolova, Dina Rusinova, Svetlana Polyakova, Evgeny Vasilyev, Vasily Petrov, Anatoly Tiulpakov Autoimmune Endocrine Disease
P1-152 Noonan syndrome-causing SHP2 mutant inhibits murine growth plate chondrogenesis and bone development: role of Ras/MAPK hyperactivation Armelle Yart, Mylène Tajan, Florence Capilla, Nicolas Beton, Jean-Luc Davignon, Maithé Tauber, Jean-Pierre Salles, Thomas Edouard Bone, Growth Plate and Mineral Metabolism
P1-153 Relationship between Vitamin D and Brainstem Auditory Evoked Potentials (BAEPs) Murat Doğan, İlyas Aydın, Keziban Aslı Bala, Sultan Kaba, Özlem Gülpınar Bone, Growth Plate and Mineral Metabolism
P1-154 Novel Compound Heterozygous BMP1 variants associated with Osteogenesis Imperfecta Aram Yang, Rimm Huh, Jinsup Kim, Sung Yoon Cho, Dong-Kyu Jin Bone, Growth Plate and Mineral Metabolism
P1-155 Prospective Cognitive Assessment in Children with Craniopharyngioma Identifies Dysfunction at Diagnosis, After Conservative Surgery and Before Adjuvant Radiation. Penelope Rodriguez-Cabrera, Adam Kuczynski, Maria Michaelidou, Laura Losa, Helen Spoudeas Endocrine Oncology
P1-156 CUSHING SYNDROME DUE TO ADRENOCORTICAL CARCINOMA IN A 3 MONTH OLD INFANT WITH A LARGE INTERSTITIAL DELETION OF CHROMOSOME 5Q INCLUDING THE APC GENE Halit Ilker Akkurt, Esther Schulz, Konrad Reinshagen, Inga Vater, Almuth Caliebe, Jessika Johannsen Endocrine Oncology
P1-157 How do Adolescent Minors Banking Sperm Before Cancer Therapy Subsequently Use the Fertility Service? A Post Banking Re-evaluation. James Pigot, Maria Michaelidou, Elizabeth Williamson, Alison Webb, Hoong-Wei Gan, Helen Spoudeas Endocrine Oncology
P1-158 The Expression of Related Neuroendocrine Factors with Puberty Onset in Rat at Different Developmental Stages Mo Kyung Jung, Ki Eun Kim, Ah Reum Kwon, Hyun Wook Hyun Wook, Duk Hee Kim, Ho-Seong Kim Pituitary
P1-159 FOXL2 gene and combined pituitary hormone deficiency: a possible link Sarah Castets, Alexandru Saveanu, Christine Raybaud, Delphine Mallet, Florence Roucher, Yves Morel, Thierry Brue, Rachel Reynaud, Marc Nicolino Pituitary
P1-16 Diverse presentations of hypophosphatasia in pediatric patients: a review of the case literature Eileen K Sawyer, Karen Anderson Bone, Growth Plate and Mineral Metabolism
P1-160 Septo-optic dysplasia (SOD) associated with Koolen-de Vries syndrome (KDVS): a case report Ani Aroyo, Iva Stoeva, Gergana Stancheva, Reni Koleva, Radka Kaneva Pituitary
P1-161 Screening of IGSF1 in patients with Central Hypothyroidism and GH deficiency, participating in the Dutch HYPOPIT study Melitza Elizabeth, Robin Peeters, Theo Visser, Anita Hokken-Koelega, Laura de Graaff Pituitary
P1-162 Congenital Hypothyroidism: Reduction in the Female to Male Ratio Following the Decrease of the TSH Cut-off Point Used for Neonatal Screening Antonis Voutetakis, Vassiliki Giogli, Dimitris Platis, Anna Gika, Alexandra Iliadi, Chrysanthi Mengreli, George Chrousos, Christina Kanaka-Gantenbein, Panagiotis Girginoudis Thyroid
P1-163 Pediatric Thyroid Nodule Score (PTNS): Derivation and Validation of a Predictive Score for Thyroid Nodule Assessment in Children Danielle van der Kaay, Jonathan Wasserman, Nadia Akseer, Michael Roskies, Frederique la Liberte, Lily Nguyen, Pramod Puligandla Thyroid
P1-164 Practical application of elastography in the diagnosis of thyroid nodules in children. Hanna Borysewicz-Sanczyk, Beata Sawicka, Janusz Dzieciol, Katarzyna Drzewek, Magdalena Oleksinska, Klaudyna Noiszewska, Artur Bossowski Thyroid
P1-165 Higher urinary iodine levels iodine correlates with lower systolic blood pressure in Chilean schoolchildren Francisca Grob, Alejandro Martínez-Aguayo, María Clara Ateaga, Carolina Loureiro, Diego Carrillo, Caroline Hill, Carmen Campino, Carolina Mendoza, Clarita Ferrada, Rodrigo Bancalari, Constanza Pinochet, Cristian Carvajal, Marlene Aglony, Carolina Valdivia, Andrea Vecchiola, Carmen Carrasco, René Baudrand, Cristobal Fuentes, Hernán García, Carlos Fardella Miscellaneous
P1-17 Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of Dexamethasone in a model of arthritis Bettina Sederquist, Cecilia Aulin, Farasat Zaman, Lars Sävendahl Bone, Growth Plate and Mineral Metabolism
P1-18 RESPONSE TO VITAMIN D REPLACEMENT IS DETERMINED BY BODY SURFACE AREA IN CHILDREN WITH VITAMIN D DEFICIENCY In Hyuk Chung, Yu Sun Kang, Eun-Gyong Yoo Bone, Growth Plate and Mineral Metabolism
P1-19 Bone-Muscle Unit Assessment With pQCT In Children With Inflammatory Bowel Disease Following Treatment With Infliximab Mabrouka Altowati, UMM-IE-SALMA Malik, Sheila Shepherd, Paraic Mcgrogan, Richard Russell, Faisal Ahmed, S. C. Wong Bone, Growth Plate and Mineral Metabolism
P1-2 ONTOGENY OF THE SYNCHRONIZATION BETWEEN ADRENAL CLOCK GENES, ADRENAL STEROIDOGENESIS-RELATED GENES AND THE CIRCADIAN RHYTHM OF THE HPA AXIS IN RATS Silvia Ruiz, Clarissa Martins, Margaret Castro, Sonir Antonini, Edson Martinez, Ayrton Moreira Adrenals and HPA Axis
P1-20 24 hydroxylase polymorphism as a possible contributor to the increased 1, 25(OH)2D in African Americans Thomas O Carpenter, David EC Cole, Laleh Ardeshirpour, Shadab Salehpour Bone, Growth Plate and Mineral Metabolism
P1-21 Effects of inorganic phosphate and FGF23 on C2C12 myoblast cells Adalbert Raimann, Alexander Dangl, Susanne Greber-Platzer, Monika Egerbacher, Gabriele Haeusler Bone, Growth Plate and Mineral Metabolism
P1-22 EVALUATION OF BONE MINERAL DENSITY AND MICROARCHITECTURAL PARAMETERS BY DXA AND HR-pQCT IN 36 X-LINKED HYPOPHOSPHATEMIC RICKETS PATIENTS FROM A SINGLE-CENTER STUDY Guido de Paula Colares Neto, Rosa Maria Rodrigues Pereira, Jackeline Couto Alvarenga, Liliam Takayama, Mariana Ferreira de Assis Funari, Regina Matsunaga Martin Bone, Growth Plate and Mineral Metabolism
P1-23 Safety and efficacy of treatment with long-acting lanreotide autogel® in early infancy in patients with congenital hyperinsulinism Heike Corda, Thomas Meissner, Sebastian Kummer, Alena Welters, Norbert Teig Diabetes and Insulin
P1-24 The influence of miR-125b in pancreatic β-cell apoptosis Bei Han, Ziyang Zhu, Wei Gu, Shining Ni, Ruixue Yang, Xing Shi, Xuewen Yuan, Wentao Gao Diabetes and Insulin
P1-25 Lower Bone Mineral Density in type 1 Diabetes Mellitus (T1DM) is probably associated with Wnt/β-catenin pathway downregulation through increased Dickkopf-1 levels Kyriaki Karavanaki, Charalampos Tsentidis, Lydia Kossiva, Antonios Marmarinos, Artemis Doulgeraki, Dimitrios Gourgiotis Diabetes and Insulin
P1-26 Human Placenta-Derived Mesenchymal Stem Cells: a novel protocol for pancreatic differentiation. Viviana Dora Patianna, Bernard Okere, Barbara Predieri, Patrizia Bruzzi, Lorenzo Iughetti Diabetes and Insulin
P1-27 Activation of insulin signaling in gastrocnemius after central leptin infusion is associated with an increase in proliferation and muscle fiber size Vicente Barrios, Emma Burgos-Ramos, Sandra Canelles, Amaia Rodríguez, Javier Gómez-Ambrosi, Julie A. Chowen, Gema Frühbeck, Jesús Argente Diabetes and Insulin
P1-28 Clinical characterisation of a novel RFX6 mutation- a rare cause of neonatal diabetes syndrome Moira Cheung, Simon Chapman, Katie Hunt, Erin Makin, Ann Hickey, Jonathan Hind, Sian Ellard, Charles Buchanan, Ritika Kapoor Diabetes and Insulin
P1-29 Is reduced heart rate variability associated with arterial stiffness in youth with childhood-onset type 1 diabetes mellitus? Hwa Young Kim, Hae Woon Jung, Gyung Min Lee, So Youn Kim, Kyung A Jeong, Keun Hee Choi, Jieun Lee, Young Ah Lee, Choong Ho Shin, Sei Won Yang Diabetes and Insulin
P1-3 Are heterozygous carriers of CYP21A2 less vulnerable to psychological stress? Anna Nordenström, Agnieszka Butwicka, Henrik Falhammar, Angelica Lindén Hirschberg, Catharina Almqvist, Agneta Nordenskjöld, Louise Frisén Adrenals and HPA Axis
P1-30 A NOVEL MUTATION IN THE ABCC8 GENE CAUSING A VARIABLE PHENOTYPE OF IMPAIRED GLUCOSE METABOLISM IN THE SAME FAMILY Evelina Maines, Khalid Hussain, Sarah E. Flanagan, Sian Ellard, Claudia Piona, Grazia Grazia Morandi, Sarah Dal Ben, Paolo Cavarzere, Franco Franco Antoniazzi, Rossella Gaudino Diabetes and Insulin
P1-31 Type 1 Diabetes Onset: a story of innate and adaptive immune cells? Ana Laura Fitas, Catarina Martins, Anabela Alonso, Glória Nunes, Rosa Pina, Daniela Amaral, Sigurd Lenzen, Lurdes Lopes, Luis Miguel Borrego, Catarina Limbert Diabetes and Insulin
P1-32 Etiological diagnosis of diabetes in Italian diabetic children and adolescents Maurizio Delvecchio, Giuseppina Salzano, Enza Mozzillo, Giulio Frontino, Ippolita Patrizia Patera, Sonia Toni, Ivana Rabbone, Valentino Cherubini, Stefano Tumini, Giuseppe D'Annunzio, Lorenzo Iughetti, Giulio Maltoni, Vittoria Cauvin, Marco Marigliano, Fabrizio Barbetti Diabetes and Insulin
P1-33 Improved genetic testing for monogenic diabetes in the Swiss population by targeted next generation sequencing Mirjam Dirlewanger, Jean-Louis Blouin, Philippe Klee, Montserrat Castellsague-Perolini, Céline Girardin, Federico Santoni, Valérie Schwitzgebel Diabetes and Insulin
P1-34 Low bone mineral density is associated to poor glycemic control and increased dickkopf-1 (DKK-1) serum levels in children and adolescents with type 1 diabetes Maria Felicia Faienza, Maurizio Delvecchio, Anna Fusillo, Antonella Lonero, Clara Zecchino, Angelo Acquafredda, Laura Piacente, Maria Grano, Luciano Cavallo, Giacomina Brunetti Diabetes and Insulin
P1-35 Effect of 6 months therapy with Metreleptin in an African American boy with Congenital generalized lipodystrophy. Svetlana Ten, Amrit Bhangoo, Divya Khurana, Mark Flyer, Abhimanyu Garg Diabetes and Insulin
P1-36 Somatic paternal UPD on chromosome 11p15 in focal form of congenital hyperinsulinism (CHI) causes monoallelic expression of mutant ABCC8 and KCNJ11 Ina Dallmann, Silke Vogelgesang, Winfried Barthlen, Emine Varol, Wolfgang Mohnike, Susann Empting, Klaus Mohnike, Martin Zenker, Ilse Wieland Diabetes and Insulin
P1-37 Hyperthyroidism in 276 Children and Adolescents with Type 1 Diabetes from Germany and Austria Axel Dost, Tilman R. Rohrer, Elke Fröhlich-Reiterer, Esther Bollow, Beate Karges, Andreas Böckmann, Johannes Hamann, Reinhard W. Holl Diabetes and Insulin
P1-38 METABOLIC SYNDROME FREQUENCY IN LONGITUDINALLY FOLLOWED CHILDREN WITH PREMATURE ADRENARCHE DURING PUBERTAL AGES Gamze Kaya, Sükran Poyrazoglu, Oguz Bulent Erol, Seha Saygili, Mine Sükür, Firdevs Bas, Ruveyde Bundak, Feyza Darendeliler Diabetes and Insulin
P1-39 EVALUATION OF ABILITY OF URINARY PODOCALYXIN, NEPHRIN AND LIVER TYPE FATTY ACID BINDING PROTEIN FOR EARLY DIAGNOSIS IN RENAL INJURY IN ADOLESCENTS WITH TYPE 1 DIABETES seniha kiremitci yilmaz, fatma taneli, arzu oran, gülgün yilmaz ovali, betül ersoy Diabetes and Insulin
P1-4 Effect of CYP17A1 inhibitors orteronel and galeterone on adrenal androgen biosynthesis. Sameer S. Udhane, Amit V. Pandey Adrenals and HPA Axis
P1-40 Efficacy and safety of a fixed combination of insulin degludec/ insulin aspart in children and adolescents with type 1 diabetes Tadej Battelino, Larry Deeb, Panagiota Diamantopoulou Reiter, Tina Maria Greve, Georgeanna Klingensmith, Miriana Kocova, Margarita Kovarenko, Naim Shehadeh Diabetes and Insulin
P1-41 Current care and outcomes for children and young people with diabetes in England and Wales: Results from the National Paediatric Diabetes Audit Naomi Holman, Fiona Campbell, Justin Warner Diabetes and Insulin
P1-42 Dynamics perceptions of their own health in the process of learning self-control adolescents with type 1 diabetes mellitus Olena Budreiko, Olena Kirilova, Sergey Tsylyuryk, Svitlana Chumak Diabetes and Insulin
P1-43 Evaluation of median nerve in children with type1 diabetes using ultrasonographic imaging and electrophysiology Nancy Elbarbary, Abeer Maghawry, Rana ElHilaly, Rania Refaat Diabetes and Insulin
P1-44 Is metabolic control affected by military service in young adults with type 1 diabetes? Avivit Brener, Eran Mel, Shlomit Shalitin, Liora Lazar, Liat de Vries, Ariel Tenebaum, Tal Oron, Moshe Philip, Yael Lebenthal Diabetes and Insulin
P1-45 IMMUNE/INFLAMMATORY PROFILE IN CHILDREN WITH TYPE 1 DIABETES MELLITUS AND CELIAC DISEASE AND/OR AUTOIMMUNE THYROIDITIS Valentina Fattorusso, Mario Galgani, Enza Mozzillo, Marianna Santopaolo, Rosa Nugnes, Giuseppe Matarese, Adriana Franzese Autoimmune Endocrine Disease
P1-46 Trends in insulin therapy in 50,861 children and adolescents with type 1 diabetes from Austria and Germany between 2000 and 2014 Barbara Bohn, Susanna Wiegand, Sebastian Kummer, Ulrike Menzel, Olga Kordonouri, Claudia Böttcher, Elke Fröhlich-Reiterer, Reinhard W. Holl Diabetes and Insulin
P1-47 RELATIVE HYPOALDOSTERONISM IN A PATIENT WITH WOLCOTT-RALLISON SYNDROME Ahmet Ucar, Yusuf Aydemir, Ayse Dogan, Ebru Tuncez Diabetes and Insulin
P1-48 Structured Education Programmes for Children with Type 1 Diabetes – A Systematic Review Anbezhil Subbarayan Diabetes and Insulin
P1-49 Can hypothalamic obesity be treated with stimulants? -Follow up Friederike Denzer, Belinda Lennerz, Heike Vollbach, Christian Denzer, Martin Wabitsch Fat Metabolism, Obesity
P1-5 Genetic heterogeneity in triple A syndrome – discrimination of the classic syndrome from two triple A-like syndromes Angela Huebner, Felix Reschke, Ingo Kurth, Susann Kutzner, Eda Utine, Filiz Hazan, Dana Landgraf, Christian A. Hübner, Katrin Koehler Adrenals and HPA Axis
P1-50 A feasibility study of intra-gastric balloons (supported by a lifestyle programme) for the treatment of severe adolescent obesity - the (BOB) Study. Pooja Sachdev, Lindesy Reece, Rob Copeland, Mike Thomson, Anuja Natarajan, Jerry Wales, Neil Wright Fat Metabolism, Obesity
P1-51 Distribution of obesity indices among European preschool children and associated risk factors: the ToyBox-study Sonya Galcheva, Mina Lateva, Violeta Iotova, Ilse De Bourdeaudhuij, Greet Cardon, Odysseas Androutsos, Zbigniew Kulaga, Piotr Socha, Luis Moreno, Berthold Koletzko, Yannis Manios, ToyBox-study Group Fat Metabolism, Obesity
P1-52 A Randomized Trial of the Effects of Perinatal Education of Overweight Pregnant Women to Prevent Childhood Overweight: the ETOIG study. Sophie PARAT, Emmanuel COSSON, Amandine BAPTISTE, Marie-Therese TAUBER, Paul VALENSI, Anne-Marie BERTRAND, Myriam DABBAS, Caroline ELIE, Françoise LORENZINI, Veronique NEGRE Fat Metabolism, Obesity
P1-53 Perypheral neuroblastic tumors and ROHHADNET syndrome (Rapid-onset Obesity with Hypothalamic dysfunction, Hypoventilation, Autonomic Dysregulation and NEural Tumor) Flavia Napoli, Ramona Tallone, Annalisa Calcagno, Stefania Sorrentino, Anna Allegri, Natascia Di Iorgi, Mohamad Maghnie Fat Metabolism, Obesity
P1-54 “bestPWS EU”: A Phase 3 study in adolescent and adult patients with PWS in Europe Maithe Tauber, Terri Kim, Nerissa Kreher, Dennis Kim, Berthold Hauffa Fat Metabolism, Obesity
P1-55 Intrauterine growth restriction is associated with greater severity in childhood obesity-associated metabolic impairment and poorer adult height prediction Rocío González-Leal, Julián Martínez-Villanueva, Jesús Argente, Gabriel Á. Martos-Moreno Fat Metabolism, Obesity
P1-56 Immunohistochemical detection of estrogen α and androgen receptors in genital tissues in girls with congenital adrenal hyperplasia Irina Kopylova, Elizaveta Orlova, Veronika Sysoeva, Tatyana Glybina, Mariia Kareva Gonads and Gynaecology
P1-57 Attitudes of parents of Klinefelter boys and Flemish pediatricians towards neonatal screening and fertility preservation techniques in Klinefelter syndrome. Inge Gies, Herman Tournaye, Jean De Schepper Gonads and Gynaecology
P1-58 Long-Term Endocrine Outcome In Men With Partial Androgen Insensitivity Syndrome Angela K Lucas-Herald, S Faisal Ahmed, Silvano Bertelloni, Anders Juul, Jillian Bryce, Jipu Jiang, Martina Rodie, Marie L Johansen, Olaf Hiort, Paul-Martin Holterhus, Martine Cools, An Desloovere, Naomi Weintrob, Sabine E Hannema, Tulay Guran, Feyzad Darendeliler, Anna Nordenstrom, Ieuan Hughes Sex Differentiation
P1-59 Novel Genetic Associations In Children With Disorders Of Sex Development (DSD) And Neurodevelopment Disorders – Insights From The Deciphering Developmental Disorders (DDD) Study Gabriella Gazdagh, DDD Study, Edward S. Tobias, S. Faisal Ahmed, Ruth McGowan Sex Differentiation
P1-6 Genetic diagnosis of congenital primary adrenal insufficiency by Massive Parallel Sequencing (MPS). Florence Roucher Boulez, Delphine Mallet Motak, Mad-Helenie Guerrin Elsensohn, Claire Bardel, Pascal Roy, Yves Morel Adrenals and HPA Axis
P1-60 Insight into the Human Ovarian Sex Development Networks Leila Bouazzi, Mariangela Franco, Wassim Eid, Monika Meyer-Böni, Patrick Sproll, Alexander Maret, Anna Lauber-Biason Sex Differentiation
P1-61 Current Models Of Practice & Professional Development Of Clinicians In DSD Centres – Results From An International Survey Of Specialist Care For DSD. Andreas Kyriakou, Arianne B Dessens, Jillian Bryce, Ira Haraldsen, Violeta Iotova, Anders Juul, Maciej Krawczynski, Agneta Nordenskjöld, Marta Rozas, Caroline Sanders, Olaf Hiort, S Faisal Ahmed Sex Differentiation
P1-62 Prediction of germ cell cancer occurrence in postpubertal individuals with androgen insensitivity based on pathological findings and cancer predisposition SNPs Martine Cools, Katja P Wolffenbuttel, Jana Kaprova, Berenice B Mendonca, Sten LS Drop, Remko Hersmus, Hans Stoop, Ad JM Gillis, Elaine MF Costa, Soraiah Domenice, Lutsz Wunsch, Charmian Quigley, Wiebke Arlt, Guy T'Sjoen, Leendert HJ Looijenga Sex Differentiation
P1-63 Gender identity prediction in adulthood by HTP test (House-Tree-Family) in 46, XY DSD patients Rafael Loch Batista, Marlene Inacio, Ari Oliveira Jr, Vinicius N Brito, Elaine M F Costa, Sorahia Domenice, Berenice B Mendonça Sex Differentiation
P1-64 MAMLD1 mutations seem not sufficient to explain a 46,XY DSD phenotype. What else? Núria Camats, Mónica Fernández-Cancio, Laura Audí, Primus E Mullis, Francisca Moreno, Isabel González Casado, Juan Pedro López-Siguero, Raquel Corripio, José Antonio Bermúdez de la Vega, José Antonio Blanco, Christa E Flück Sex Differentiation
P1-65 Subcutaneous continuous administration of recombinant human luteinizing and follicle-stimulating hormones is an effective treatment for micropenis during the mini-puberty Athanasia Stoupa, Dinane Samara-Boustani, Isabelle Flechtner, Graziella Pinto, Isabelle Jourdon, Kathleen Laborde, Didier Chevenne, Anne-Elodie Millischer-Bellaiche, Michel Polak, Jacques Beltrand Sex Differentiation
P1-66 46,XX ovotesticular DSD in the absence of SRY gene associated to SOX3 duplication Romina P. Grinspon, Julián Nevado, María de los Angeles Mori Alvarez, Rodolfo A. Rey, Graciela del Rey, Ana Chiesa Sex Differentiation
P1-67 miR-146a-mediated suppression of the inflammatory response in human adipocytes Julian Roos, Eveliina Enlund, Daniel Tews, Jan-Bernd Funcke, Verena Zoller, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky Fat Metabolism, Obesity
P1-68 Leptin resistance alteration after modulation of dopamine system funcional activity in rat's diet-induced obesity Liudmila Viazava, Angzhalika Solntsva, Alexander Sukalo, Alena Dashkevich, Julia Stukach Fat Metabolism, Obesity
P1-7 Carriers of 21- Hydroxylase Deficiency Demonstrate Increased Psychological Vulnerability to Stress Georgia Koltsida, Ioanna Farakla, Aikaterini Papanikolaou, Gerasimos Kolaitis, Emilia Mantzou, Evangelia Charmandari Adrenals and HPA Axis
P1-70 Outcome of Adolescents Undergoing Bariatric Surgery – One Year Follow-up Michal Ben-Ami, Maayan Bacher, Irena Vusiker, Reut Pink, Daniel Stein, Benjamin Vagner, Gal Raz-Dubnov, Danny Yardeni, Orit PInhas-Hamiel Fat Metabolism, Obesity
P1-71 Identifying critical periods for maintaining weight loss in obese children Amanda Peacock, Talat Mushtaq, Erin Alexander, Helen Truby, Darren Greenwood, Vince Russo, Steven Yau, George Werther, Matthew Sabin Fat Metabolism, Obesity
P1-72 Use of topiramate in severe hyperphagia associated to neuropsychiatric features in a boy with congenital proopiomelanocortin deficiency (POMC) Romana Marini, Sara Ciccone, Paolo Alfieri, Stefania Pedicelli, Marco Cappa Fat Metabolism, Obesity
P1-73 CIRCULATING miR146a AND 486-5p ARE ALTERED IN OBESE CHILDREN WITH AND WITHOUT NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND CORRELATE WITH ABDOMINAL FAT AND BMI. Luisa Montanini, Viviana D. Patianna, Chiara Sartori, Barbara Predieri, Patrizia Bruzzi, Pietro Lazzeroni, Silvia Merli, Paolo Bergamaschi, Sergio Bernasconi, Lorenzo Iughetti, Maria Elisabeth Street Fat Metabolism, Obesity
P1-74 Erythropoietin activates heat production and lipolysis on brown adipose tissue and consequently reduces obesity in dietary-induced obese mice Kazuki Kodo, Hisakazu Nakajima, Satoru Sugimoto, Ikuyo Itoh, Shota Fukuhara, Shigehara keiichi, Taichiro Nishikawa, Jun Mori, Kitaro Kosaka, Hajime Hosoi Fat Metabolism, Obesity
P1-75 Ghrelin and brain-derived neurotrophic factor in children with Prader-Willi syndrome. Elena Bogova, Natalya Volevodz, Valentina Peterkova Fat Metabolism, Obesity
P1-76 Endothelial Progenitor Cells in Obese Non-diabetic Children and Adolescents: Relations to Some Metabolic Parameters, Echocardiographic Parameters and Tissue Doppler Imaging Alaa Ahmed, Omneya Youssef, Botheina Thabet Fat Metabolism, Obesity
P1-77 Evaluation of adiponectin concentrations in obese children and its correlation with lipid and carbohydrate parameters Malgorzata Ruminska, Anna Majcher, Beata Pyrzak Fat Metabolism, Obesity
P1-78 Influence of Genetic Variation on the Response to Recombinant Human Growth Hormone (GH) Treatment in Children with GH Deficiency: An Analysis of 13 Single Nucleotide Polymorphisms and the GH Receptor Exon 3 Deletion Anna-Maria Jung, Paul Francois Hoffmann, Dominik Monz, Christina Lissewski, Denny Schanze, Martin Zenker, Tilman Robert Rohrer GH and IGF Treatment
P1-79 Decrease of jumping power in adolescents with severe GHD (sGHD) after stop of GH-therapy Roland Schweizer, Julian Ziegler, Gerhard Binder GH and IGF Treatment
P1-8 CORTISOL – CORTISONE RATIO AND METALLOPROTEINASE-9 EMERGING AS RISK FACTORS ASSOCIATED WITH PEDIATRICS HIPERTENSION Alejandro Martinez-Aguayo, Carmen Campino, Rene Baudrand, Cristian Carvajal, Constanza Pinochet, Hernan Garcia, Rodrigo Bancalari, Alejandra Tapia, Lorena Garcia, Carolina Loureiro, Carolina Mendoza, Andrea Vecchiola, Carolina Valdivia, Cristobal Fuente, Carlos Lagos, Francisca Grob, Sandra Solari, Fidel Allende, Alexis Kalergis, Carlos Fardella Adrenals and HPA Axis
P1-80 GOOD CLINICAL RESPONSE TO GROWTH HORMONE THERAPY IN A BOY WITH A COMBINATION OF FAMILIAR SHORT STATURE CAUSED BY NOVEL p.Val478Serfs*14 MUTATION IN ACAN GENE AND ISOLATED GROWTH HORMONE DEFICIENCY Stepanka Pruhova, Lenka Dusatkova, Petra Dusatkova, Dana Zemkova, Jan Lebl GH and IGF Treatment
P1-81 The growth response to growth hormone treatment is greater in patients with SHOX enhancer deletions compared to SHOX defects. Stephany Donze, Caroline Meijer, Sarina Kant, Gladys Zandwijken, Annemieke van der Hout, Resie van Spaendonk, Ans van den Ouweland, Jan Maarten Wit, Monique Losekoot, Wilma Oostdijk GH and IGF Treatment
P1-82 Assessment of Primary Cancers in Growth Hormone (GH)–Treated Paediatric Patients Compared with General Population Registries: An Epidemiological Analysis of a Large, Multinational, Prospective Observational Study Christopher Child, Alan Zimmermann, Nan Jia, Leslie Robison, Jürgen Brämswig, Werner Blum GH and IGF Treatment
P1-83 Genetic markers contribute to the Prediction of response to GH in severe but not mild GH deficiency Adam Stevens, Philip Murray, Jerome Wojcik, John Raelson, Ekaterina Koledova, Pierre Chatelain, Peter Clayton GH and IGF Treatment
P1-84 Disease and Treatment Burden In Children And Adolescents with Growth Hormone Deficiency (GHD) Meryl Brod, Lise Højbjerre, Suzanne Alolga, Alise Nacson, Lars Nordholm, Michael Højby Rassmussen GH and IGF Treatment
P1-85 EFFECTS OF GROWTH HORMONE TREATMENT ON IMMUNITY Ramón Cañete, María Dolores Caballero, Rocío Aguado, Manuel Santamaría GH and IGF Treatment
P1-86 The growth hormone treatment results in the increase of irisin concentration in plasma Beata Wikiera, Katarzyna Pukajlo, Lukasz Laczmanski, Natalia Sloka, Aleksander Basiak, Anna Noczynska, Marek Bolanowski, Jacek Daroszewski GH and IGF Treatment
P1-87 A novel OTX2 gene mutation in a child with growth hormone deficiency Antonella Lonero, Maurizio Delvecchio, Paola Primignani, Roberto Caputo, Fabrizia De Palma, Vincenza Luce, Maria Felicia Faienza, Luciano Cavallo GH and IGF Treatment
P1-88 The dose dependent effect of growth hormone therapy in patients with IGF-1 receptor haploinsufficiency due to heterozygous deletion Haruo Mizuno, Kohei Aoyama, Tatsushi Tanaka, Shinji Saitoh GH and IGF Treatment
P1-89 Royal Jelly supplementation induces the growth plate development and increases plasma growth hormone and estradiol levels in prepubertal rats Murat Sever, Ozgur Pirgon, Metin Ciris, Bunyamin Aydin Growth
P1-9 Founder Effect and the Clinical and Molecular Characteristics in a Cohort of Classical and Non-Classical Congenital Lipoid Adrenal Hyperplasia (CLAH) due to StAR Mutations Abdulsalam Abu-Libdeh, Ariella Weinberg Shokrun, Ephrat Levy-Lahad, Osnat Admoni, Yardena Tenenbaum-Rakover, David Zangen Adrenals and HPA Axis
P1-90 Silver-Russell syndrome without body asymmetry in three patients with duplications of maternally derived chromosome 11p15 involving CDKN1C Shinichi Nakashima, Fumiko Kato, Tomoki Kosho, Keisuke Nagasaki, Toru Kikuchi, Masayo Kagami, Maki Fukami, Tsutomu Ogata Growth
P1-91 Mutation in RTTN, a regulator of ciliary function, causes a complex syndrome characterized by severe congenital microcephaly, lissencephaly and profound growth failure in two siblings Anna Grandone, Vincenzo Nigro, Annalaura Torella, Adalgisa Festa, Caterina Luongo, Pierluigi Marzuillo, Ruggero Coppola, Emanuele Miraglia del Giudice, Laura Perrone Growth
P1-92 Chronic Effects of Bisphenol A administration on Growth Hormone Activity Mohammed AL-Masroori, Mohammed Hebais, Amnah AL-Araimi, Fahad Zadjali Growth
P1-93 Severe IGF-I deficiency and multi-organ autoimmune disease associated with novel germline STAT3 mutations. Paula Scaglia, Ana Keselman, Mariana Gutiérrez, Sabina Domené, Miguel Blanco, Nora Sanguinetti, Liliana Bezrodnik, Daniela Di Giovanni, María Soledad Caldirola, Lucia Martucci, Liliana Karabatas, Ashish Kumar, Nana-Hawa Jones, Vivian Hwa, Santiago Revale, Martín Vázquez, Héctor Jasper, Horacio Domené Growth
P1-95 Various imprinting disorders underlying Silver-Russell Syndrome-compatible phenotype Masayo Kagami, Keiko Matsubara, Shinichiro Sano, Akie Nakamura, Seiji Mizuno, Naoki Hamajima, Atsuhiro Yanagisawa, Miyuki Hashimoto, Akira Yukote, Maki Fukami, Tsutomu Ogata Growth
P1-96 Ligase IV deficiency syndrome as a cause of microcephalic primordial dwarfism in dizygotic twins Céline Girardin, Emmanuelle Ranza, Philippe Klee, Mirjam Dirlewanger, Marianne Caflisch, Armand Bottani, Valérie Schwitzgebel Growth
P1-97 HIGH FREQUENCY OF HYPOMORPHIC ALLELIC HAPLOTYPES OF THE GH1 PROXIMAL PROMOTER IN PATIENTS WITH PROPORTIONAL UNDERGROWTH AND ISOLATED GH DEFICIENCY Angel Campos-Barros, Ana Gómez-Núñez, Olga Zurita-Múñoz, Elena Gallego-Gómez, Jaime Cruz-Rojo, Lucía Garzón, Cristina Luzuriaga-Tomás, Isolina Riaño-Galán, Carolina Bezanilla-López, José María Donate-Legaz, Mercedes Marbán-Calzón, Sara Rupérez, Florinda Hermoso, Emma Lara-Orejas, Mª Victoria Borrás-Pérez, Jose Manuel Rius-Peris, Beatriz García-Cuartero, Isabel González-Casado Growth
P1-98 Growth Hormone Excess in McCune-Albright Syndrome Daniele Tessaris, Alison M. Boyce, Patrizia Matarazzo, Roberto Lala, Michael T. Collins Pituitary
P1-99 Growth hormone hypersecretion in children with NF1 and optic pathway gliomas Stefania Pedicelli, Paola Cambiaso, Marina Macchiaiolo, Stefania Galassi, Angela Mastronuzzi, Francesca Del Bufalo, Graziamaria Ubertini, Marco Cappa Pituitary
P2-166 Late diagnosis of adrenal insufficiency caused by novel compound heterozygous mutations in POMC. Elena Frolova, Irina Shirokova, Svetlana Karpova, Anna Kolodkina, Nina Makretskaya, Anatoly Tiulpakov Adrenals and HPA Axis
P2-167 Hyponatraemia secondary to exudative eczema Irene Pilar Fernandez Viseras, Michal Ajzensztejn Adrenals and HPA Axis
P2-168 The Natural Mutant Receptor hGRαT556I Causes Primary Generalized Glucocorticoid Resistance Through Decreased Affinity for the Ligand and Impaired Interaction with the GRIP1 Coactivator Nicolas C. Nicolaides, Eirini Skyrla, Dimitrios Vlachakis, Anna-Maria G. Psarra, Amalia Sertedaki, Sophia Kossida, Evangelia Charmandari Adrenals and HPA Axis
P2-169 References values under Synacthen® test for 6 steroids in serum by LC-MS/MS marie Souillot, ingrid Plotton, chantal Rigaud, veronique Tardy, severine Ruet, yves Morel Adrenals and HPA Axis
P2-170 Usefulness of salivary cortisol levels in secondary adrenal insufficiency in pediatric population Raquel Corripio, Jacobo Pérez, Ariadna Borràs, Laura Capdevila, Judith Sánchez, Josefa Rivera Adrenals and HPA Axis
P2-171 Acute adrenal failure in a term newborn with congenital cytomegalovirus infection: case description and review of the literature Lucia Marseglia, Tommaso Alterio, Lauretta Manti, Tommaso Aversa, Maria Rosa Calafiore, Eloisa Gitto, Malgorzata Wasniewska Adrenals and HPA Axis
P2-172 Resveratrol disrupts steroidogenesis in human fetal adrenals Iuliia Savchuk, Olle Söder, Konstantin Svechnikov Adrenals and HPA Axis
P2-173 Normal Ranges of Basal and Glucagon-Stimulated Free Cortisol in Children Anita Schachter Davidov, Ori Eyal, Anat Becker Anat, Asaf Oren, Naftali Stern, Rona Limor, Naomi Weintrob Adrenals and HPA Axis
P2-174 CLINICAL, BIOCHEMICAL AND MOLECULAR CHARACTERISTICS OF THE PATIENTS WITH NONCLASSICAL CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY IN CROATIA Miroslav Dumic, Nevena Krnic, Vesna Kusec, Zorana Grubic, Katarina Stingl, Tony Yuen, Katja Dumic Kubat, Veselin Skrabic, Maria I. New Adrenals and HPA Axis
P2-175 Abnormal circadian blood pressure profile in patients with congenital adrenal hyperplasia without overt hypertension Dominika Janus, Malgorzata Wojcik, Katarzyna Tyrawa, Jerzy Starzyk Adrenals and HPA Axis
P2-176 Triple A syndrome - the second most common cause of chronic adrenal insufficiency in North Africa? Kahina Mohammedi, Asmahane Ladjouze, Ammar Tebaibia, Leila Kedji, Abdelmajid Maoudj, Karima Berkouk, Manoubia Bensmina, Souhila Amoura, Mohamed El Amine Boudjella, Abdennour Laraba Adrenals and HPA Axis
P2-177 Analysis the relationship between clinical characteristics and genotype of six cases of Bartter syndrome and Gitelman syndrome in children zhang jun, chen qiuli, guo song, yang ping, ma huamei, li yanhong, du minlian Miscellaneous
P2-178 Genotypic heterogeneity and clinical phenotype in two patients with triple A syndrome (AAAS). Antonella Meloni, Maria Rosaria Casini, Roberta Mazzitti, Riccardo Congia, Maria Cristina Rosatelli, Marco Bonomi Miscellaneous
P2-179 Primary adrenal insufficiency: About a pediatric series imen nardine, nora soumeya fedala, boubker derghoum, leyla ahmed ali, ali el mahdi haddam, djamila meskine, farida chentli Adrenals and HPA Axis
P2-180 High-dose Hook Effect in 17- Hydroxyprogesterone Assay in 21-hydroxylase deficiency Mesut Parlak, Doga Turkkahraman, Ayse Eda Parlak, Hamit Yasar Ellidag Adrenals and HPA Axis
P2-181 Baseline cortisol concentrations predict positively and negatively anti- and pro- oxidation, respectively that are measured following an acute aerobic exercise bout in pre- and early pubertal normal-weight and obese boys. George Paltoglou, Maria Papagianni, Ioannis G. Fatouros, Aimilia Mantzou, Athanasios Jamurtas, Alexandra Avloniti, Charikleia Stefanaki, Christina Kanaka-Gantenbein, George P. Chrousos, George Mastorakos Adrenals and HPA Axis
P2-182 Insulin sensitivity and adipocytokynes in children with Classical Congenital Adrenal Hyperplasia Nicola Improda, Manuela Cerbone, Andrea Esposito, Flavia Barbieri, Raffaella Di Mase, Donatella Capalbo, Mariacarolina Salerno Adrenals and HPA Axis
P2-183 24-hour urinary free cortisol as a screening test for Cushing’s syndrome in children. Lucy Shapiro, Shezan Elahi, Joe Baliey, Les Perry, Lee Martin, Ashley Grossman, Scott Akker, John Monson, William Drake, Martin Savage, Helen Storr Adrenals and HPA Axis
P2-184 Familial Hyporeninemic Hyperkalemia and Hypertension (Pseudohypoaldosteronism Type II) in Infancy and Childhood. Aaron Hanukoglu, Shira London, Rafael Halevi, Yardena Tenenbaum-Rakover Adrenals and HPA Axis
P2-185 Severe craniosynostosis syndrome associated to salt wasting congenital adrenal hyperplasia Luciana Amorim Beltrão, Elisa Cordeiro Apolinario, Liana Capelo Costa, Yve Lozovei, Simone Martins Castro, Rafael Fabiano Machado Rosa, Cristiane Kopacek Adrenals and HPA Axis
P2-186 TESTICULAR ADRENAL CELL REST TUMORS ARE NOT ASSOCIATED WITH 21 HYDROXYLASE MUTATIONS OR THERAPY COMPLIANCE IN BOYS WITH CLASSIC FORM OF CAH Mirjana Kocova, Vesna Janevska, Violeta Anastasovska, Elena Sukarova-Angelovska Adrenals and HPA Axis
P2-187 A large family with a novel mutation in the SCNN1A gene causing a mild and transient form of autosomal recessive Pseudohypoaldosteronism type 1 (PHA1) Alexandra Efthymiadou, Amalia Sertedaki, George Chrousos, Dionisios Chrysis Adrenals and HPA Axis
P2-188 Phosphoglucomutase -1 deficiency presented as adrenal insufficiency Neta Loewenthal, Ruti Parvari, Alon Haim, Judy Tavashi, Eli Hetshkovits Adrenals and HPA Axis
P2-189 The etiological spectrum of congenital adrenal hyperplasia based on molecular genetic analyses Jin-Ho Choi, Ja Hye Kim, Eungu Kang, Ja Hyang Cho, Gu-Hwan Kim, Han-Wook Yoo Adrenals and HPA Axis
P2-190 Higher serum DHEAS concentration is associated with lower plasma LDL cholesterol concentration in children Aino Mäntyselkä, Jarmo Jääskeläinen, Virpi Lindi, Timo Lakka Adrenals and HPA Axis
P2-191 Central adrenal insufficiency is not a common feature in CHARGE syndrome Gianni Bocca, Monica Wong, Conny van Ravenswaaij-Arts Adrenals and HPA Axis
P2-192 Baseline adrenal function by measurement of long term cortisol levels in scalp hair of asthmatic children using inhaled corticosteroids equals healthy controls. Maria Smit, Ed van Leer, Gerard Noppe, Yolanda de Rijke, Jurriaan Hoekx, Erica van den Akker Adrenals and HPA Axis
P2-193 Adrenal function in children born small for gestational age Indre Petraitiene, Rasa Verkauskiene Adrenals and HPA Axis
P2-194 Cushing's syndrome in children and adolescents : About a pediatric serie aicha houatia, soumeya nora fedala, ali el mahdi haddam, djamila meskine, farida chentli Adrenals and HPA Axis
P2-195 Serum cortisol and cortisone ratio as sensitive tool to identify subjects with severe or partial 11β-hydroxysteroid dehydrogenase type 2 deficiency Cristian Carvajal, Virginia Iturrieta, Carmen Campino, Carolina Valdivia, Jaime Lizama, Fidel Allende, Sandra Solari, René Baudrand, Carlos Lagos, Andrea Vecchiola, Alejandro Martínez-Aguayo, Hernán García, Carlos Fardella Adrenals and HPA Axis
P2-196 The role of de Nurse practitioner in optimizing care for Children with Congenital Adrenal Hyperplasia Viviane van de Crommert, Janiëlle van Alfen-van der Velden, Annelieke van der Linde, Kees Noordam, Hedi Claahsen-van der Grinten Adrenals and HPA Axis
P2-197 Evaluation of medical treatment in the first 2 years of life with a new Dutch national longitudinal registry for children with congenital adrenal hyperplasia (CAH) Annelieke van der Linde, Erica van den Akker, Willy Bakker- van Waarde, Sabine Hannema, Gea Hoorweg-Nijman, Hetty van de Kamp, Daniel Klink, Roelof Odink, Saartje Straetemans, Paul van Trotsenburg, Paul Verkerk, Hedi Claahsen-van der Grinten Adrenals and HPA Axis
P2-198 Incidence of nonclassical 21-hydroxylase deficiency in Russian population as estimated by the carrier frequency of V281L mutation Tatiana Anosova, Anatoly Tiulpakov Adrenals and HPA Axis
P2-199 CARDIO-METABOLIC RISK FACTORS IN CHILDREN AND ADOLESCENTS WITH CLASSICAL 21-HYDROXYLASE DEFICIENCY Kansuda Ariyawatkul, Supatporn Tepmongkol, Taninee Sahakitrungruang Adrenals and HPA Axis
P2-200 A novel mutation (c.delG209) in the proopiomelanocortin (POMC) gene in a child with early-onset obesity Semra Cetinkaya, Tulay Guran, Erdal Kurnaz, Meliksah Keskin, Elif Sagsak, Senay Savas Erdeve, Federica Buonocore, Zehra Aycan Adrenals and HPA Axis
P2-201 IMPROVED LINEAR GROWTH IN PATIENTS WITH CLASSICAL CONGENITAL ADRENAL HYPERPLASIA. Silvia Roma, Carla Bizzarri, Giuseppe Scirè, Gian Luigi Spadoni, Marco Cappa, Chiara Maggioli Adrenals and HPA Axis
P2-202 Autoimmune polyglandular syndrome type 1 in Russia: clinical experience in 112 patients. Elizaveta Orlova, Leila Sozaeva, Maria Kareva, Bergithe E. Oftedal, Lars Breivik, Per M. Knappskog, Ekaterina Zakharova, Eystein S. Husebye, Valentina Peterkova Autoimmune Endocrine Disease
P2-203 Autoimmune encephalitis - a newly recognised clinical manifestation of autoimmune polyendocrine syndrome type 1? Juliana Ferenczova, Veronika Vargova, David Krysl, Erika Banoova, Eva Sadova Autoimmune Endocrine Disease
P2-204 Children With Coeliac Disease On Gluten Free Diet Have Normal Bone Mass, Geometry And Muscle Mass M Mackinder, S C Wong, M Tsiountsioura, S Shepherd, E Buchanan, C Edwards, S F Ahmed, K Gerasimidis Bone, Growth Plate and Mineral Metabolism
P2-205 Mechanism of bone disease in Prader-Willi syndrome Maria Felicia Faienza, Giacomina Brunetti, Graziano Grugni, Antonino Crinò, Sarah Bocchini, Angela Oranger, Isabella Gigante, Laura Piacente, Annamaria Ventura, Silvia Colucci, Maria Grano, Luciano Cavallo, Maurizio Delvecchio Bone, Growth Plate and Mineral Metabolism
P2-206 Hereditary vitamin D-resistant rickets (HVDRR): Report of four cases with successful use of intermittent intravenous calcium via peripheral route Saygin Abali, Mayuko Tamura, Zeynep Atay, Pinar Isguven, Tulay Guran, Belma Haliloglu, Serpil Bas, Tsuyoshi Isojima, Serap Turan, Sachiko Kitanaka, Abdullah Bereket Bone, Growth Plate and Mineral Metabolism
P2-207 A novel PRKAR1A gene mutation with mild brachydactyly Hiroko Yagi, Masaki Takagi, Toshikastu Mistui, Tomonobu Hasegawa, Yukihiro Hasegawa Bone, Growth Plate and Mineral Metabolism
P2-208 Bone mineral density in children and adolescents with vertical HIV infection. Deisi Maria Vargas, Daniela Oliveira Prust, Jose Carlos Galvão Bone, Growth Plate and Mineral Metabolism
P2-209 Sclerostin and its associations with energy metabolism in children and adolescents Anna Wedrychowicz, Jerzy Starzyk Bone, Growth Plate and Mineral Metabolism
P2-210 Genetic and epigenetic alterations at the GNAS locus and clinical consequences in Pseudohypoparathyroidism: a new healthcare pathway Federica Giachero, Francesca M. Elli, Marta Baricco, Patrizia Matarazzo, Giovanna Mantovani, Luisa de Sanctis Bone, Growth Plate and Mineral Metabolism
P2-211 Fibrous cortical defects and non-ossifying fibromas in patients with precocious puberty Bang Won Lee, Kyung-Sue Shin Bone, Growth Plate and Mineral Metabolism
P2-212 The effect of high dose oral 17ß estradiol on bone mineralization and body composition in young women with Turner syndrome - a 5 year randomized controlled clinical trial Line Cleemann, Kirsten Holm, Hanne Kobbernagel, Bent Kristensen, Sven Olaf Skouby, Andreas Emil Kryger Jensen, Claus Gravholt Bone, Growth Plate and Mineral Metabolism
P2-213 Comparison of cost benefits and efficacy of Zoledronic acid and Pamidronate in the treatment of Osteogenesis Imperfecta in children. Vrinda Saraff, Jaskiran Sahota, Nicola Crabtree, Nick Shaw, Wolfgang Högler Bone, Growth Plate and Mineral Metabolism
P2-214 TmP/GFR is a useful marker in making a clinical diagnosis of X-linked hypophosphatemic rickets caused by the PHEX gene mutation Ryojun Takeda, Kentaro Miyai, Masaki Takagi, Masahiro Goto, Daisuke Ariyasu, Masako Izawa, Junko Igaki, Eri Suzuki, Yoshie Nakamura, Yukihiro Hasegawa Bone, Growth Plate and Mineral Metabolism
P2-215 Whole body vibration training improves physical function and increases bone and muscle mass in youngsters with mild cerebral palsy Silmara Gusso, Patricia Colle, Jose G B Derraik, Janene Biggs, Craig Munns, Wayne Cutfield, Paul Hofman Bone, Growth Plate and Mineral Metabolism
P2-216 A CASE WITH ACRODYSOSTOSIS AND HORMONE RESISTANCE Selma Tunç, Korcan Demir, Filiz Hazan, Özgür Kırbıyık, Eren Soyaltın, Özlem Nalbantoğlu, Melek Yıldız, Hüseyin Anıl Korkmaz, Behzat Özkan Miscellaneous
P2-217 The spectrum of molecular defects in 64 patients with hypophosphatemic rickets identified by targeted next-generation sequencing. Kristina Kulikova, Anna Kolodkina, Evgeny Vasilyev, Vasily Petrov, Fedor Gofman, Anatoly Horkin, Vladimir Kenis, Michael Petrov, Anatoly Tiulpakov Bone, Growth Plate and Mineral Metabolism
P2-218 NEPHROCALCINOSIS AND NEPHROLITHIASIS IN 36 X-LINKED HYPOPHOSPHATEMIC RICKETS PATIENTS: DIAGNOSTIC IMAGING AND EVALUATION OF RISK FACTORS IN A SINGLE-CENTER STUDY Guido de Paula Colares Neto, Fernando Ide Yamauchi, Ronaldo Hueb Baroni, Igor Fontenele, Andrea Cavalanti Gomes, Maria Cristina Chammas, Regina Matsunaga Bone, Growth Plate and Mineral Metabolism
P2-219 Early increase of the bone formation marker PINP is in a higher degree related to growth response compared to bone mineralization in GH treated prepubertal children Ralph Decker, Björn Andersson, Diana Swolin-Eide, Per Magnusson, Berit Kriström, Kerstin Albertsson-Wikland Bone, Growth Plate and Mineral Metabolism
P2-220 Genotype and phenotype characteristics in 22 patients with Vitamin D Dependent Rickets Type I (VDDR1) Sophia Tahir, Huseyin Demirbilek, Mehmet Nuri Ozbek, Riza Taner Baran, Sibel Tanriverdi, Khalid Hussain Bone, Growth Plate and Mineral Metabolism
P2-221 Evidence of a link between resting energy expenditure and bone remodelling, glucose homeostasis and adipokine variations in adolescent girls with anorexia nervosa Laurent Maimoun, Sebastien Guillaume, Patrick Lefbvre, Pascal Philibert, Helena Bertet, Marie-Christine Picot, Laura Gaspari, Françoise Paris, Maude Sennec, Anne-Marie Dupuys, Philippe Courtet, Eric Thomas, Denis Mariano-Goulart, Jacques Bringer, Eric Renard, Charles Sultan Bone, Growth Plate and Mineral Metabolism
P2-222 Bone density, HIV infection and antiretroviral treatment: a 10-year follow-up in young patients Stefano Mora, Katia Maruca, Alessandro Ambrosi, Maria Puzzovio, Paola Erba, Pilar Nannini, Annarita Benincaso, Silvia Capelli, Vania Giacomet Bone, Growth Plate and Mineral Metabolism
P2-223 Refractory Hypercalcaemia of Malignancy: Responsiveness to Denosumab and Zoledronate Dinesh Giri, Renuka Ramakrishnan, James Hayden, Lynda Brook, Urmi Das, M.Zulf Mughal, Peter Selby, Poonam Dharmaraj, Senthil Senniappan Bone, Growth Plate and Mineral Metabolism
P2-224 Fractures In Boys With Duchenne Muscular Dystrophy And Their Relationship To Age Shuko Joseph, Marina Di Marco, Iain Horrocks, S Faisal Ahmed, S C Wong Bone, Growth Plate and Mineral Metabolism
P2-225 Early Detection of Increased Bone Turnover among Children and Adolescents with Type 1 Diabetes Mellitus Amina Abdel Wahab, Sonia El Sharkawy, Fadia Attia, Mona Amin Bone, Growth Plate and Mineral Metabolism
P2-226 Association between oxidative stress and bone turnover markers in the obese children Pawel Matusik, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek, Ewa Malecka-Tendera Bone, Growth Plate and Mineral Metabolism
P2-227 Longitudinal bone development in patients with classical congenital adrenal hyperplasia: data using peripheral quantitative computed tomography Susanne Bechtold, Leyla Duman, Claudia Weissenbacher, Julia Roeb, Robert Dalla Pozza, Heinrich Schmidt Bone, Growth Plate and Mineral Metabolism
P2-228 Online Survey to Characterize the Burden of Illness in Children with X-linked Hypophosphatemia (XLH) Agnes Linglart MD, PhD, Melita Dvorak-Ewell, PhD, Ayla Marshall, Javier San Martin, MD, Alison Skrinar, PhD Bone, Growth Plate and Mineral Metabolism
P2-229 Comparison of the response to bisphosphonate treatment between acute lymphoblastic leukaemia and osteogenesis imperfecta type I Suma Uday, Anitha Kumaran, Nimasari Ginige, Sophia Sakka, Vrinda Saraff, J Sahota, Nicola Crabtree, Nick Shaw, Wolfgang Högler Bone, Growth Plate and Mineral Metabolism
P2-230 The relationship between serum 25-hydroxyvitamin D and parathyroid hormone in children Hae Soon Kim, Jung In Kang, Ye Jin Han Bone, Growth Plate and Mineral Metabolism
P2-231 Cinacalcet treatment in girls with hereditary vitamin D resistant rickets Erkan Sari, Firat Ozkececi, Onur Akin, Ahmet Bolat, Ediz Yesilkaya Bone, Growth Plate and Mineral Metabolism
P2-232 Regulation of bone growth via ligand-specific activation of estrogen receptor alpha Maryam Iravani, Marie Lagerquist, Claes Ohlsson, Lars Savendahl Bone, Growth Plate and Mineral Metabolism
P2-233 Teriparatide (rhPTH) therapy in a boy with Hypoparathyroidism-Deafness-Renal dysplasia (HDR) syndrome due to GATA3 mutation Dinesh Giri, Senthil Senniappan, Poonam Dharmaraj, Lynne Hatchard, Renuka Ramakrishnan Bone, Growth Plate and Mineral Metabolism
P2-234 Variable degree of hormonal resistance in patients with Progressive Osseous Heteroplasia Kentaro Miyai, Noriko Nishina, Masaki Takagi, Masahiro Goto, Yukihiro Hasegawa Bone, Growth Plate and Mineral Metabolism
P2-235 Assessment of foramen magnum in early infancy is efficient for patients with achondroplasia Chisumi Sogi, Miki Kamimura, Akiko Hakoda, Junko Kanno, Ikuma Fujiwara, Shigeo Kure Bone, Growth Plate and Mineral Metabolism
P2-236 Body composition measures on different DEXA scanners are not the same Udo Meinhardt, Fabienne Witassek, Christiane Fritz, Urs Eiholzer Bone, Growth Plate and Mineral Metabolism
P2-237 Intrauterine growth restriction, gestational age, steroidal prophylaxis and breastfeeding influence bone mass in prepubertal children Annalisa Calcagno, Giovanna Pala, Anna Elsa Maria Allegri, Flavia Napoli, Nadia Fratangeli, Maria Grazia Calevo, Mohamad Maghnie, Natascia Di Iorgi Bone, Growth Plate and Mineral Metabolism
P2-238 Can vitamin D deficiency cause prolongation in visual evoked potentials? Murat Doğan, İlyas Aydin, Sultan Kaba, Keziban Aslı Bala, Özlem Gülpınar Bone, Growth Plate and Mineral Metabolism
P2-239 Novel CYP27B1 Gene Mutations in Children with Vitamin D-Dependent Rickets Type 1A Korcan Demir, Walaa E Kattan, Minjing Zou, Erdem Durmaz, Huda BinEssa, Ozlem Nalbantoglu, Roua A.Al-Rijjal, Brian Meyer, Behzat Ozkan, Yufei Shi Bone, Growth Plate and Mineral Metabolism
P2-240 Size-corrected bone mineral density is not affected by haematopoietic stem cell transplantation and total body irradiation (HSCT/TBI) in leukaemia survivors Christina Wei, Ruth Elson, Rachel Cox, Karin Bradley, John Barton, Michael Stevens, Elizabeth Crowne Bone, Growth Plate and Mineral Metabolism
P2-241 Quantitative Sonometeric Bone Age (SBA) as a Function of Height and BMI Alina German, Nira Koren-Morag, Shmuel Levin, Ze'ev Hochberg Bone, Growth Plate and Mineral Metabolism
P2-242 THE ASSOCIATION OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) AND AUTISM SPECTRUM DISORDERS (ASD) WITH THE MEAN PLATELET VOLUME (MPV) AND VITAMIN D Keziban Aslı Bala, Murat Doğan, Tuba Mutluer, Sultan Kaba, Oktay Aslan, Nihat Demir, Lokman Üstyol Miscellaneous
P2-243 Dyslipidemia in Children with Diabetes Pei Kwee Lim, Rashida Vasanwala, Tuck Seng Cheng, Ngee Lek, Yuen Ching Angela Hui, Soo Ting Lim, Fabian Yap Diabetes and Insulin
P2-244 Diabetes mellitus and hypoparathyroidism in a girl with mitochondrial disease Gonul Buyukyilmaz, Nazli Gonc, Goknur Haliloglu, Beril Talim, Alev Ozon, Ayfer Alikasifoglu, Nurgun Kandemir Diabetes and Insulin
P2-245 Association of ghrelin levels and insulin resistance in small for gestational age rats wangkai liu, zhenyu shen, minlian du, siqi zhuang, huamei ma Diabetes and Insulin
P2-246 Protective Effects of Combined Intervention with Adenovirus Vector Mediated IL-10 and IGF-1 Genes on Endogenous Islet β Cells in Nonobese Diabetes Mice with Onset of Type 1 Diabetes Mellitus Tang Li Diabetes and Insulin
P2-247 A case of Donohue Syndrome : New Genetic Mutation and added phenotypic characteristics Fawzia Alyafei, Mahmoud Zyoid, , Ashraf Soliman, Anas Abdulkayoum, Rawia Jarir, Bader Kurdi, Laila Mahmoud Diabetes and Insulin
P2-248 Genetic analysis and follow-up of 23 neonatal diabetes mellitus patients in China Cao bingyan, Gong chunxiu, Wu di, Lu chaoxia, Liu Fang, Liu Xiaojing, Zhang Ying-xian, Gu Yi, Qi Zhan, Li Xiaoqiao, Liu Min, Li Wenjing, Su Chang, Liang Xuejun, Feng Mei Diabetes and Insulin
P2-249 Level of knowledge about type I diabetes mellitus among nurses employed at endocrinological dispensaries Akmaral Tashmanova Diabetes and Insulin
P2-250 Recombinant human insulin-like growth factor-1 treatment in patients with insulin receptor mutations resulting in Donohue syndrome: a 10-year experience in a tertiary centre. Nicola Improda, Harshini Katugampola, Pratik Shah, Hannah Gordon, Rakesh Amin, Catherine J Peters, Robert K Semple, Mehul T Dattani Diabetes and Insulin
P2-251 Sick day rule: Survey of parents of children with Type 1 diabetes (experience and Knowledge) Juliana Chizomam Agwu, S May Ng, J DREW, J EDGE, M KERSHAW, N WRIGHT, C GARDNER Diabetes and Insulin
P2-252 Brachial Flow Mediated Dilation and its Relation to Osteoprotegerin in Type 1 Diabetes Mellitus Eman Sherief, Omneyia Youssef, Karim Abd El-Tawab, Hoda Ez-elarab, Moaz Ibrahim, Nermine Amr Diabetes and Insulin
P2-253 Value of the intrarenal arterial resistivity indices and different renal biomarkers for early identification of diabetic nephropathy in type 1 diabetic patients. Ahmed Battah, Soha Abd El Dayem, Abo El Magd El Bohy, Amal El Shohaby, Nagwa Abd Allah Diabetes and Insulin
P2-254 Can we rely on finger stick haemoglobin A1c? Comparison of levels assayed by DCA 2000 with IFCC reference method in a pediatric cohort Gianluca Tornese, Nadia Milic, Laura Spetti, Daniela Gembrini, Carmen Loganes, Maria Chiara Pellegrin, Lucia Radillo, Oriano Radillo, Elena Faleschini, Alessandro Ventura Diabetes and Insulin
P2-255 Significant impact of nocturnal melatonin secretion on obesity-related metabolic disorders in children and adolescents Johanna Overberg, Peter Kühnen, Andrea Ernert, Heiko Krude, Susanna Wiegand Diabetes and Insulin
P2-256 Exposure to phthalates and phenols in relation to gestational blood glucose homeostasis Benjamin G. Fisher, Hanne Frederiksen, Anna-Maria Andersson, Anders Juul, A Thankamony, Kenneth K. Ong, David B. Dunger, Ieuan A. Hughes Diabetes and Insulin
P2-257 Developing a targeted, mobile-health technology (e-book) to promote self-care during diabetes transition Andrew Dwyer, Samaita Unal, Severine Emmanouilidis, Marie-Paule Aquarone-Vaucher, Silvia Pichard, Teresa Gyuriga, Joelle Korpes, Francois Jornayvaz, Elena Gonzalez-Rodriguez, Eglantine Elowe-Gruau, Sophie Stoppa, Anne Zanchi-Delacretaz, Jardena Puder, Francesca Amati, Therese Bouthors, Franziska Phan-Hug, Nelly Pitteloud, Michael Hauschild Diabetes and Insulin
P2-258 CARDIAC AUTONOMIC NEUROPATHY IS HIGHLY PREDICTIVE FOR SURVIVAL IN CHILDREN WITH MAURIAC SYNDROME Margarita Arshinkova, Olga Slavcheva, Maia Konstantinova Diabetes and Insulin
P2-259 Predictors of Cystic Fibrosis-Related Diabetes (CFRD) in Patients with CF and Pancreatic Insufficiency Joseph Meyerovitch, Rony Be'eri Berkowiz, Meir Mei-Zahav, Hannah Blau, Huda Mussaffi-Georgy Diabetes and Insulin
P2-260 Adherence to diabetes care in children and adolescents with Type 1 Diabetes Mellitus in Spain: Results from the CHRYSTAL Study. Juan Pedro López Siguero, Luis Alberto Vázquez, Renata Villoro, Dingfeng Jiang, María Merino, Jesús Reviriego, Magaly Perez-Nieves Diabetes and Insulin
P2-261 Gaining from patient experience on a local level: The introduction of annual questionnaires for children and teenagers with diabetes Emily Cottrell, Manju Chandwani, Frances Hanson, James Wong Diabetes and Insulin
P2-262 Factitious administration of analogue insulin to a 2 year old child Nehal Thanawala, Sarah Cheney, Gwen Wark, Mario Thevis, A Thomas, V Tziaferi, James Greening Diabetes and Insulin
P2-263 Insulin Sensitivity in Adolescents with Gender Dysphoria during Puberty Suppressing Therapy with GnRH Agonists Sebastian Schagen, Henriette Delemarre-van de Waal, Sabine Hannema Diabetes and Insulin
P2-264 Ethnic variation in the correlation of waist circumference to daily insulin requirement in children with type 1 diabetes Suma Uday, Shaun Gorman, Richard Feltbower, Mathew Mathai Diabetes and Insulin
P2-265 IMPORTANCE OF THROMBOCYTE VOLUME PARAMETERS IN TYPE I DIABETES MELLITUS PATIENTS WITH AND WITHOUT CLINICAL FINDINGS OF DIABETIC KETOACIDOSIS Dogus Vuralli, Hatice Tatar Aksoy, Arzu Yilmaz, Ozlem Engiz, Yildiz Bilge Dallar Diabetes and Insulin
P2-266 Increased Arterial Wall Stiffness in Children with Type 1 Diabetes and Poor Metabolic Control: An Early Marker of Vascular Complications? Barbora Obermannova, Lenka Petruzelkova, Terezie Sulakova, Zdenek Sumnik Diabetes and Insulin
P2-267 Glycaemic dysregulation in transfusion dependent thalassaemia patient in a children’s hospital SONG HAI LIM, WILKINS LIM, THIAN LIAN SOO Diabetes and Insulin
P2-268 MODY-GCK and MODY-HNF1A in children and adolescents in Russian population Elena Sechko, Lubov Zilberman, Olga Ivanova, Tamara Kuraeva, Valentina Peterkova Diabetes and Insulin
P2-269 Clinical and hormonal profile in Mini-puberty of daughters born after pregnancies with diabetes: preliminary report Joel Riquelme, Daniela Martínez, Teresa Sir-Petermann, Claudio Villarroel, Ethel Codner Diabetes and Insulin
P2-270 Growth and Endocrinopathy in Wolfram Syndrome: the experience of a nationally commissioned specialist clinic. Melanie Kershaw, Susan Gleeson, Denise Williams, Rajat Gupta, John Ainsworth, Archana Kulkarni, Liam McCarthy, Lesley MacPherson, Rachel Bates, Marie McGee, Timothy G Barrett Diabetes and Insulin
P2-271 Evaluation of a Novel Tool to Adjust Insulin Boluses based on Continuous Glucose Monitoring Trend Arrows and Insulin Sensitivity (Trend Arrow Adjustment Tool©) in Children and Youth with Type 1 Diabetes using Insulin Pump Therapy Emmeline Heffernan, Margaret Lawson, Brenda Bradley, Jennilea Courtney, Christine Richardson Diabetes and Insulin
P2-272 Circulating GLP-1 in infants born small-for-gestational-age: breast-feeding versus formula-feeding Marta Díaz, Judit Bassols, Giorgia Sebastiani, Abel López-Bermejo, Lourdes Ibáñez, Francis de Zegher Diabetes and Insulin
P2-273 Utility of estimated glucose disposal rate and fat mass percentage for predicting metabolic syndrome in children and adolescents with type 1 diabetes Ozlem Koken, Cengiz Kara, Gulay Can Yilmaz, Murat Aydin Diabetes and Insulin
P2-274 Friedreich’s Ataxia presenting with Diabetes Mellitus in an adolescent Serpil Bas, Saygin Abali, Zeynep Atay, Ziya Gurbanov, Dilsad Turkdogan, Serap Turan, Abdullah Bereket Diabetes and Insulin
P2-275 DO PANCREATIC FUNCTIONS PREDICT CARDIAC AND LIVER IRON LOADING IN TRANSFUSION-DEPENDENT BETA THALASSEMIA MAJOR PATIENTS USING CARDIOVASCULAR AND LIVER T2-STAR (T2*)MAGNETIC RESONANCE ? Galila Mokhtar, Wafaa Ibrahim, Nancy Elbarbary, Randa Matter, Ahmed Ibrahim, Safa Sayed Diabetes and Insulin
P2-276 Determinants of outcome of children with type 1 diabetes in Cameroon. Loveline Niba, Benedikt Aulinger, Wilfred Mbacham, Klaus Parhofer Diabetes and Insulin
P2-277 Psychosocial Screening in children with Type 1 Diabetes in Ireland Elena Hennessy, Patricia Gallagher, Triona Butler, Norma O’Toole, Susan M O’Connell, Stephen MP O’Riordan Diabetes and Insulin
P2-278 Neonatal Diabetes –Experience from a single center in Sri Lanka Navoda Atapattu, Vasundara Vithanage, Kirikankanange Shamya Harshini de Silva, Daham Haresha de Silva, Mala Mangalika Jayathilaka, Andrew T Hattersley, Sian Ellard, Sarah E. Flanagan, J.A.L Houghton, Khalid Hussain Diabetes and Insulin
P2-279 Dive: a serious game for diabetes therapeutic education in children Cecile Godot, Nadine Lepage, Isabelle Jourdon, Marie-Eve Schmidt, Pierre Maccini, Michel Polak, Jacques Beltrand Diabetes and Insulin
P2-280 GLUCOSE AND INSULIN RESPONSE AT STANDARD ORAL GLUCOSE LOAD AND FOLLOWED SUBMAXIMAL TREADMILL TEST IN OBESE ADOLESCENTS Tetyana Chaychenko, Olena Rybka Diabetes and Insulin
P2-281 Insulin Dynamics and Biochemical Markers for Predicting Impaired Glucose Tolerance in Thai Obese Youth Sirapassorn Tirabanchasak, Sukumarn Siripunthana, Vichit Supornsilchai, Suttipong Wacharasindhu, Taninee Sahakitrungruang Diabetes and Insulin
P2-282 Total-Body Irradiation is a major risk factor for young adult onset diabetes mellitus and hyperlipidemia in childhood cancer survivors after hematopoietic stem cell transplantation. Ryuichi Nakagawa, Atsumi Tsuji, Yuki Aoki, Keisuke Nakajima, Akito Sutani, Yuichi Miyakawa, Kei Takasawa, Daisuke Tomizawa, Masatoshi Takagi, Kenichi Kashimada, Tomohiro Morio Diabetes and Insulin
P2-283 Variables in Diabetic Children and Adolescents associated with High, Acceptable and Low range of Glycosylated Haemoglobin (HbA1c) in a DGH setting – An Analysis Karthi Manoharan, Sharon Lim Diabetes and Insulin
P2-284 In-patient care for children with type 1 diabetes- a regional audit in the Yorkshire and Humber region in the north of England. Suma Uday, Nadia Amin, Fiona Campbell, James Yong Diabetes and Insulin
P2-285 Implementation of Effective Transition from Paediatric to Adult Diabetes Care: Epidemiological and clinical characteristics. A pioneering experience in North Africa. ESSADDAM Leïla, TURKI Zinet, FITOURI Zohra, BEN SLAMA Claude, MATOUSSI Nadia, BEN BECHER Saayda Diabetes and Insulin
P2-286 Assessment of Ventricular Function by Tissue Doppler Echocardiography in Children and Adolescents with Type 1 Diabetes Mellitus Shereen Abdelghaffar, Nermeen Salah, Mona Attia, Mona Hafez, Mona Mamdouh, Abeer Atef, Fatma Elmougy, Sahar Abdelaty, Amany Ibrahim, Hend Mehawed, Noha Musa, Noha Arafa, Marwa Farouk, Mohamed Ismail, Faten Abdelaziz, Aya Fattouh, Eman Hussein, Isis Ghali Diabetes and Insulin
P2-287 Incidence of Type 1 Diabetes among Korean Children and Adolescents in 2012-2013: Analysis of Data from the Nationwide Registry of Korea Jae Hyun Kim, Young Ah Lee, Sei Won Yang, Choong Ho Shin Diabetes and Insulin
P2-288 Functional condition of the kidneys (K/DOQI , 2002) by ACE gene I/D polymorphism in children and adolescents with type I diabetes mellitus Gulnara Rakhimova, Akida Sadikova, Nasiba Alimova Diabetes and Insulin
P2-289 LONGITUDINAL STUDY OF IRISH CHILDREN AND ADOLESCENTS ON CONTINUOUS SUBCUTANEOUS INSULIN INFUSION (CSII) Mary-Ellen Bohane, Niamh McGrath, Aoife Carroll, Dympna Devenney, Ciara McDonnell, Nuala Murphy Diabetes and Insulin
P2-290 C peptide variation after the diagnosis of type 1 diabetes in pediatric age Joana Correia, Catarina Mendes, Marina Pinheiro, Clara Preto, Helena Cardoso, Maria João Oliveira, Teresa Borges Diabetes and Insulin
P2-291 Metformin Utilizat