18 September 2014 |
| 07:00-17:00 | | Registration Opens
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| 08:00-11:00 | | ESPE Bone and Growth Plate Working Group (BGP)
Chair(s): Part 1: Ola Nilsson (Stockholm, Sweden) & Gabrielle Hausler (Vienna, Austria) Part 2: Serap Turan (Istanbul, Turkey) & Ollie Semler (Cologne, Germany) Debate: Malachi McKenna (Dublin, Ireland) & Ciara McDonnell (Dublin, Ireland)
Wicklow Hall 1
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| 08:00 - 08:30 | WG1.1 | Unravelling GH actions on the growth plate and its promotion of linear growth |
| 08:30 – 09:00 | WG1.2 | The effect of stimulatory G proteins on differentiation within the growth plate |
| 09:10 – 09.30 | | Coffee Break |
| 09:30 – 10.00 | WG1.3 | Denosumab as an emerging therapy in pediatric metabolic bone diseases |
| 10:00 – 10:30 | WG1.4 | New therapies in Metabolic bone disease: PTH |
| 10:30 – 11:00 | | Debate: Bisphosphonates – will drug holidays avoid atypical femoral fractures? |
| 08:00-11:00 | | ESPE Working Group on Diabetes Technology and Therapeutics
Chair(s): Tadej Battelino (Ljubljana, Slovenia)
Auditorium
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| 08:00 - 08:15 | WG2.1 | Technological horizon for diabetes treatment |
| 08:15 - 08:40 | WG2.2 | Non-Insulin Glucoregulatory therapy for type 1 diabetes |
| 08:40 - 09:15 | WG2.3 | Debate: Should all newly diagnosed patients with diabetes need to be hospitalized? |
| 08:40 - 09:15 | WG2.4 | Debate: Should all newly diagnosed patients with diabetes need to be hospitalized? |
| 09:15 - 09:40 | | Coffee Break |
| 09:40 - 10:15 | WG2.5 | Debate: Sensor/pump therapy from onset of diabetes? |
| 09:40 - 10:15 | WG2.6 | Debate: Sensor/pump therapy from onset of diabetes? |
| 10:15 - 10:50 | WG2.7 | Debate: Do we need long acting insulin analogs? |
| 10:15 - 10:50 | WG2.8 | Debate: Do we need long acting insulin analogs? |
| 08:00-11:00 | | ESPE Disorders of Sex Development Working Group (DSD)
Chair(s): Part 1: Christa Flück (Bern, Switzerland) and PM Holterhus (Kiel, Germany) Part 2: Anna Nordenström (Stockholm, Sweden)
Liffey A
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| 08:00 - 08:30 | WG3.1 | Genetic variation in human SF-1 (NR5A1): clinical consequences for individuals, families and populations |
| 08:30 - 08:50 | WG3.2 | The potential role of the alternative ‘backdoor’ pathway for androgen synthesis and virilisation in CAH |
| 08:50 - 09:15 | WG3.3 | Long term outcome of prenatal CAH- therapy |
| 09:15 - 09:45 | | Coffee Break |
| 09:45 - 10:05 | WG3.4 | Detailed phenotyping of DSD: external virilisation |
| 10:05 - 10:25 | WG3.5 | Imaging of the urogenital tract |
| 10:25 - 10:35 | WG3.6 | I-DSD and I-CAH registry update |
| 10:35 - 10:45 | WG3.7 | DSDlife |
| 10:45 - 10:55 | WG3.8 | DSDnet: A COST Action on the systematic elucidation of differences of sex development |
| 10:55 - 11:00 | | Open Business meeting |
| 08:00-11:00 | | ESPE Obesity Working Group (OWG)
Chair(s): Bessie E. Spiliotis (Patras, Greece) and Jesus Argente (Madrid, Spain)
Wicklow Hall 2
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| 08:00 - 08:30 | WG4.1 | Metabolic syndrome in youth: current insights and novel serum biomarkers |
| 08:30 - 09:00 | WG4.2 | Type 2 diabetes in children and adolescents |
| 09:00 - 09:30 | | Coffee Break |
| 09:30 - 10:00 | WG4.3 | Making a diagnosis in Severe Complex Obesity |
| 10:00 - 10:30 | WG4.4 | Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity |
| 10:30 - 11:00 | | Research and Business Meeting |
| 08:00-11:00 | | ESPE Working Group on Paediatric and Adolescent Gynaecology (PAG)
Chair(s): Part 1: Feyza Darendeliler & Marco Cappa Part 2: Lucia Ghizzoni & Jean-Pierre Bourguignon
Liffey B
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| 08:00 - 08:25 | WG5.1 | New markers of Ovarian Function |
| 08:25 - 08:50 | WG5.2 | Lessons drawn from gynecological disorders in relation with hypothalamic-pituitary malfunction |
| 08:50 - 09:15 | WG5.3 | Delay or advancement of female puberty after early life exposure to Bisphenol A and neuroendocrine mechanism |
| 09:15 - 09:45 | | Coffee Break |
| 09:45 - 10:10 | WG5.4 | Contraception in Adolescence from a Public Health Perspective |
| 10:10 - 10:35 | WG5.5 | Contraception in adolescence: current options |
| 10:35 - 11:00 | WG5.6 | Lessons drawn from rare gynecological disorders in relation with ovarian malfunction |
| 08:00-11:00 | | ESPE Turner Syndrome Working Group (TS)
Chair(s): Part 1: Berit Kriström & Laura Mazzanti Part 2: Aneta Gawlik & Theo Sas
Liffey Hall 2
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| 08:00 - 08.45 | WG6.1 | Liver involvement in Turner syndrome |
| 08:45 - 09:15 | WG6.2 | Gastrointestinal disease in TS |
| 09:15 - 09:45 | | Coffee Break |
| 09:45 - 10:15 | WG6.4 | Motor performance in TS |
| 10:15 – 11:00 | WG6.3 | Autism and the X-chromosome |
| 09:00-11:00 | | Education and Training Update
Chair(s): Part 1: Malcolm Donaldson & Jan Lebl Part 2: Rasa Verkauskiene & John Gregory
Liffey Hall 1
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| | Welcome and meeting new ESPE members and trainees |
| | Update of the 28th ESPE Summer School |
| | The Winter School journey – past, present and future |
| | Seminars in Developmental Endocrinology: Diving in Paediatric Endocrinology sea |
| | ESPE Science School: the past and the future |
| | Harmonization of Paediatric Endocrinology training in EU |
| | Drop on behalf of e-learning team - the espe-elearning.org portal: Learning and teaching paediatric endocrinology on demand |
| | ESPE Clinical Fellowship programme: starting opportunity for young Paediatric Endocrinologists |
| | Paediatric Endocrinology in the Middle East & North Africa; future plans and collaboration |
| | ESPE Maghreb School: training in French |
| | Reflections on an African (PETCA) safari |
| | ESPE Caucasus and Central Asia School: starting in 2014 |
| | ESPE Research Fellowship programme |
| 11:15-11:30 | | Opening Ceremony
Welcome and Opening Speech - ESPE President 2014
Auditorium
Session head(s): Hilary Hoey (Ireland)
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| 11:30-12:30 | | Plenary Session 1 & 2
Chair(s): Carine de Beaufort (Luxembourg City, Luxembourg) & David Dunger (Cambridge, UK)
Auditorium
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| 11:30 | PL1 | Closed-Loop System: Dream or Reality? |
| 12:00 | PL2 | Learning from histopathology to design novel immune-therapies for type 1 and 2 diabetes |
| 12:30-13:30 | | Lunch
Visit to the Posters and Exhibition
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| 12:45-13:45 | | Industry-sponsored Satellite Symposium 1
Liffey A
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| 14:00-15:30 | | Symposium 1 - Disorders of Gsalpha Signaling
Chair(s): Serap Turan (Istanbul, Turkey) & Dov Tosiano (Haifa, Israel)
Wicklow Hall 2
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| 14:00 | S1.1 | Pseudohypoparathyroidism |
| 14:30 | S1.2 | McCune Albright Syndrome |
| 15:00 | S1.3 | Acrodysostosis |
| 14:00-15:30 | | Symposium 2 - Endocrine Cancer Syndromes: An Update
Chair(s): Helen Spoudeas (London, UK) & Hermann Mueller (Oldenburg, Germany)
Liffey B
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| 14:00 | S2.1 | PTEN: A Gene Involved in Overgrowth and Cancer |
| 14:30 | S2.2 | MEN1 in Children and Adolescents |
| 15:00 | S2.3 | DICER1 syndrome: a erview of the syndrome with a focus on endocrine aspects |
| 14:00-15:30 | | Symposium 3 - Novel Insights into Monogenic Diabetes
Chair(s): Zdenek Sumnik (Prague, Czech Republic) & George Werther (Melbourne, Australia)
Auditorium
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| 14:00 | S3.1 | Differential Diagnosis of Monogenic Diabetes |
| 14:30 | S3.2 | New Genes, New Mechanisms, New Phenotypes |
| 15:00 | S3.3 | Epidemiology of Monogenic Diabetes |
| 14:00-15:30 | | Symposium 4 - Recent Advances in Our Understanding of Hypothyroidism
Chair(s): Jan -Maarten Wit (Leiden, The Netherlands) & Filippo De Luca (Messina, Italy)
Liffey A
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| 14:00 | S4.1 | Management of Central Hypothyroidism |
| 14:30 | S4.2 | Novel role(s) for immunoglobulin superfamily, member 1 (IGSF1) in the hypothalamic-pituitary-thyroid axis |
| 15:00 | S4.3 | Novel Insights into Thyroid Hormone Resistence |
| 15:30-16:00 | | Coffee Break
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| 16:00-17:00 | | Meet the Expert Parallel Sessions
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| 16:00 - 17:00 | MTE1.1 | Management of a Child with Cryptorchidism |
| 16:00 - 17:00 | MTE2.1 | The challenges of extreme obesity |
| 16:00 - 17:00 | MTE3.1 | Evaluation of Precocious Pubarche |
| 16:00 - 17:00 | MTE4.1 | Management and prevention of complications in adolescents with Diabetes |
| 16:00-17:00 | | Yearbook of Paediatric Endocrinology
Chair(s): Gary Butler (London, UK) & Peter Bang (Linköping, Sweden)
Auditorium
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| 16:00-17:00 | | New Technological Aids in Clinical Paediatric Endocrinology 1
Liffey Hall 2
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| 16:00 | NTA1.1 | The BoneXpert methods for fully automated assessment of skeletal maturity ('bone age') and adult height prediction |
| 16:30 | NTA1.2 | Growth monitor platform: New application to predict growth and synchronize data between devices |
| 17:15-18:45 | | Industry-sponsored Satellite Symposium 2
Liffey A
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| 19:00- | | Welcome Reception
CCD
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19 September 2014 |
| 07:00- | | Registration Opens
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| 07:30-08:30 | | Meet the Expert Parallel Sessions
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| 07:30 - 08:30 | MTE5.1 | Management of childhood fractures |
| 07:30 - 08:30 | MTE6.1 | Assessment of Thyroid Nodules |
| 07:30 - 08:30 | MTE7.1 | Clinical Management of Cystic Fibrosis Related Diabetes (CFRD) in Childhood |
| 07:30 - 08:30 | MTE8.1 | Evaluation and the Management of Tall Stature |
| 07:30-08:30 | | New Technological Aids in Clinical Paediatric Endocrinology 2
Liffey Hall 2
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| 07:30 | NTA2.1 | Two girls with precocious puberty; application of the www.espe-elearning.org portal for interactive classroom teaching on your personal mobile device. |
| 08:30-08:45 | | Coffee Break
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| 08:45-09:45 | | Free Communication 1 - Adrenal
Chair(s): Evangelia Charmandari (Athens, Greece) & Anna Lauber Biason (Fribourg, Switzerland)
Liffey Hall 2
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| 08:45 | FC1.1 | Molecular Mechanisms of Nongenomic Glucocorticoid Actions: The Role of Human Glucocorticoid Receptor S-Palmitoylation. |
| 08:55 | FC1.2 | Clinical phenotype of patients with MCM4 mutation suggests pubertal delay in males in addition to adrenal failure, absent adrenarche and short stature in boys and girls |
| 09:05 | FC1.3 | Genetic engineering using TALENs to study the redox regulation of steroidogenesis in vivo |
| 09:15 | FC1.4 | A novel non-invasive Short Synacthen Test |
| 09:25 | FC1.5 | Antenatal glucocorticoid treatment and polymorphisms in glucocorticoid and mineralocorticoid receptor genes are associated with long-term |
| 09:35 | FC1.6 | Molecular Characterization of Testicular Adrenal Rest Tumours (TART) in Congenital Adrenal Hyperplasia (CAH); Lesions with both Adrenocortical and Leydig Cell Features |
| 08:45-09:45 | | Free Communication 2- Bone & Mineral
Chair(s): Nick Shaw (Birmingham, UK) & Ciara McDonnell (Dublin, Ireland)
Liffey Hall 1
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| 08:45 | FC2.1 | Asfotase Alfa: Sustained Improved Growth and Function with Extended Treatment in Children with Hypophosphatasia |
| 08:55 | FC2.2 | Hypophosphatasia: Gross motor function and height improvement in infants and young children treated with asfotase alfa for up to 3 years |
| 09:05 | FC2.3 | Calcium Homeostasis in Adolescents with Beta-Thalassemia Major: Effect of Intramuscular Injection of a Megadose of Cholecalciferol |
| 09:15 | FC2.4 | Fractures in children with chronic inflammatory and/or disabling conditions: the SNAP study |
| 09:25 | FC2.5 | Pharmacokinetics (PK) and Pharmacodynamics (PD) of a Human Monoclonal Anti-FGF23 (Fibroblast Growth Factor 23) Antibody (KRN23) Following Four Month Intra-Dose Escalation in Adults with X-linked Hypophosphatemia (XLH) |
| 09:35 | FC2.6 | Efficacy and Safety Following Four Monthly Subcutaneous (SC) Doses of a Human Anti-FGF23 (Fibroblast Growth Factor 23) Antibody (KRN23) in Adults with X-Linked Hypophosphatemia (XLH) |
| 08:45-09:45 | | Free Communication 3 - Diabetes
Chair(s): John Gregory (Cardiff, UK) & Nuala Murphy (Dublin, Ireland)
Liffey A
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| 08:45 | FC3.1 | HIGH MOBILITY GROUP BOX-1(HMGB-1) SERUM CONCENTRATIONS INCREASE AT ONSET OF DIABETES IN CYSTIC FIBROSIS (CF) PATIENTS |
| 08:55 | FC3.2 | HbA1c level as a predictive marker of progression to clinical diabetes |
| 09:05 | FC3.3 | Improved hepatic insulin sensitivity in children randomized to CSII treatment from onset of type 1 diabetes |
| 09:15 | FC3.4 | Genetics of pediatric type 2 diabetes: ABCC8 mutation in obesity-associated insulin secretion defects |
| 09:25 | FC3.5 | Pancreatic N-Methyl-D-Aspartate receptors as novel drug targets for the treatment of diabetes mellitus |
| 09:35 | FC3.6 | ALPHA-LIPOIC ACID AND ANTI-OXIDANT DIET HELPS TO IMPROVE ENDOTHELIAL DYSFUNCTION IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES. |
| 08:45-09:45 | | Free Communication 4- Growth
Chair(s): Veronica Mericq (Santiago, Chile) & Stefano Cianfarani (Rome, Italy)
Wicklow Hall 2
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| 08:45 | FC4.1 | HETEROZYGOUS IGF1R MUTATIONS REPRESENT A FREQUENT FINDING IN PATIENTS WITH PRE- AND/OR POSTNATAL PROPORTIONAL UNDERGROWTH AND LOW, NORMAL OR SUPRANORMAL IGF1 |
| 08:55 | FC4.2 | The effect of GRB10-deficiency in Zebrafish: a translational animal model to study human growth |
| 09:05 | FC4.3 | Oscillations in gene expression profiles across childhood highlight the relation of growth and specific metabolic functions in both sexes |
| 09:15 | FC4.4 | Short stature, accelerated bone maturation, and early growth cessation due to heterozygous aggrecan mutations |
| 09:25 | FC4.5 | Fetal and postnatal growth in Turner Syndrome and their associations with the dosage effects of the X-linked gene: a cross-sectional data base analysis of the French national rare disease network |
| 09:35 | FC4.6 | LONGITUDINAL GROWTH OF FINNISH CHILDREN WITH GESTATIONAL DIABETES IN MOTHERS |
| 08:45-09:45 | | Free Communication 5- Neuroendocrinology
Chair(s): Nicholas de Roux (Paris, France) & Taneli Raivio (Helsinki, Finland)
Wicklow Hall 1
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| 08:45 | FC5.1 | Derivation of GnRH neuron-like cells from human embryonic stem cell-derived neural crest progenitors |
| 08:55 | FC5.2 | Mutations in the maternally imprinted gene MKRN3 are a frequent cause of familial central precocious puberty |
| 09:05 | FC5.3 | Loss of Function Mutations in PNPLA6 Cause Hypogonadotropic Hypogonadism due to Impaired LH Release from Pituitary Gonadotropes |
| 09:15 | FC5.4 | Reference values for urinary gonadotropins in preterm and full-term infants in “minipuberty” |
| 09:25 | FC5.5 | Characterization of IGF-I receptor expression and localization in paediatric gliomas upon diagnosis according to WHO 2007 grading |
| 09:35 | FC5.6 | The diencephalic syndrome (DS) of emaciation in infantile hypothalamochiasmatic low-grade gliomas (HCLGGs): a retrospective case-control study of diagnostic parameters and long-term outcomes over 30 years of follow-up |
| 08:45-09:45 | | New Perspectives 1
Chair(s): Mohamad Maghnie (Liguria, Italy) & Martin Wabitsch (Ulm, Germany)
Micro-RNAs in Health and Diseases
Liffey B
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| 08:45 | NP1.1 | Non Coding RNA's: Introduction to Non-Coding RNAs and the Role of MicroRNAs in GnRH Neurons |
| 09:15 | NP1.2 | The Role of MicroRNAs in Diabetes |
| 08:45-09:45 | | Yearbook of Paediatric Endocrinology
Chair(s): Franco Chiarelli (Chieti, Italy) & Angela Webber (Dresden, Germany)
Auditorium
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| 09:45-10:15 | | Coffee Break
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| 10:15-10:45 | | Plenary Session 3
Chair(s): Laura Audi (Barcelona, Spain) & Peter Clayton (Manchester, UK)
Auditorium
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| 10:15 | PL3 | Sex, Stem Cells and Decision of Cell Fate |
| 10:45-11:45 | | ESPE Award and Activities
Auditorium
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| 11:45-12:15 | | Plenary Session 4
Chair(s): Laura Audi (Barcelona, Spain) & Peter Clayton (Manchester, UK)
Auditorium
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| 11:45 | PL4 | Gene therapy in cerebral form of X-linked adrenoleukodystrophy |
| 12:30-13:30 | | Lunch
Visit to the Posters and Exhibition
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| 13:00-14:00 | | Industry-sponsored Satellite Symposium
Liffey B
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| 14:15-15:45 | | Symposium 5 - Novel Insights into Hypoadrenalism
Chair(s): Tsutomu Ogata (Hamamatsu, Japan) & Christa Fluck (Bern, Switzerland)
Auditorium
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| 14:15 | S5.1 | Aetiology of Congenital Hypoadrenalism |
| 14:45 | S5.2 | Adrenarche: Coming of age in the era of genomics and metabolomics |
| 15:15 | S5.3 | CAH: Health Status in Adults (CaHASE) |
| 14:15-15:45 | | Symposium 6 - New Concepts in the Gonadotropic Axis
Chair(s): Jean-Claude Carel (Paris, France) & Nelly Pitteloud (Lausanne, Switzerland)
Liffey A
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| 14:15 | S6.1 | Role of The Hypothalamic MicroRNA in Puberty Regulations |
| 14:45 | S6.2 | New Syndromes Resulting in Secretory Pathway and Gonadotropic Axis Regulation Defects |
| 15:15 | S6.3 | Genetic Dissection of Puberty in Mice |
| 14:15-15:45 | | Symposium 7 - Controversies in the Surgical Management of DSD
Chair(s): Peter Lee (Pennsylvania, USA) & Olaf Hiort (Lubeck, Germany)
Liffey B
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| 14:15 | S7.1 | Evolution of Feminising Genitoplasty |
| 14:30 | S7.2 | Pros and Cons of Early or Late Feminising Genitoplasty |
| 15:00 | S7.3 | Masculinising Genitoplasty |
| 14:15-15:45 | | ESPE Working Group for Paediatric Endocrine Nurse Specialists and Allied Health Professionals
Chair(s): Jacquie Lyons & Sinead Moloney
Wicklow Hall 1
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| 14.15 | WG7.1 | Quality of life and anxiety in adolescents with differentiated thyroid cancer |
| 14:35 | WG7.2 | Evolving Growth Hormone Therapy (GHT) Patient Training in a Digital World |
| 14:55 | WG7.3 | Endocrine Nursing, social media and research: results of an international study |
| 15:15 | | Open discussion |
| 14:15-15:45 | | Working Group for Global Paediatric Endocrinology and Diabetes (GPED)
Chair(s): Dr Raul Calzada & Dr Asmahane Ladjouze
Liffey Hall 1
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| 14:15 - 14:25 | WG8.1 | Word from GPED’s President |
| 14:25 - 14:35 | WG8.2 | Inequities of treatment options in developing countries: Inequities in treatment options type 1 diabetes in Sudan |
| 14:35 - 14:45 | WG8.3 | Inequities of treatment options in developing countries: Osteogenesis imperfecta in Indonesia |
| 14:45 - 14:55 | WG8.4 | Inequities of treatment options in developing countries: Congenital Adrenal Hyperplasia |
| 14:55 - 15:05 | | Q & A |
| 15:05 - 15:15 | WG8.5 | Neonatal screening for congenital hypothyroidism: Don’t take it for granted! (Costa Rica) |
| 15:15 - 15:25 | WG8.6 | Neonatal screening for congenital hypothyroidism: Don’t take it for granted! (Ghana) |
| 15:25 - 15:35 | WG8.7 | Neonatal screening for congenital hypothyroidism: Don’t take it for granted! (Nigeria) |
| 15:35 - 15:45 | | Q & A |
| 15:45-16:15 | | Coffee Break
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| 16:15-17:45 | | Industry-sponsored Satellite Symposium 4
Auditorium
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| 16:15-17:45 | | Industry-sponsored Satellite Symposium 5
Liffey B
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| 16:15-17:45 | | Industry-sponsored Satellite Symposium 6
Liffey A
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| 18:00-19:30 | | ESPE Business Meeting
Liffey A
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| 19:30- | | Free Evening
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20 September 2014 |
| 07:00- | | Registration Opens
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| 07:30-08:30 | | Meet the Expert Parallel Sessions
|
| 07:30 - 08:30 | MTE1.2 | Management of a Child with Cryptorchidism |
| 07:30 - 08:30 | MTE2.2 | The challenges of extreme obesity |
| 07:30 - 08:30 | MTE3.2 | Evaluation of Precocious Pubarche |
| 07:30 - 08:30 | MTE4.2 | Management and Prevention of Complications in Adolescents with Diabetes |
| 07:30 - 08:30 | MTE5.2 | Management of Childhood Fractures |
| 08:45-09:45 | | Free Communication 6 - Gonads & DSD
Chair(s): Abdulla Bereket (Istanbul, Turkey) & Faisal Ahmed (Glasgow, UK)
Wicklow Hall 2
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| 08:45 | FC6.1 | Search for genetic defects in the transcription factor genes FOXL2, FOXE1, BMP15, NOBOX and GDF9 in children, adolescents and young adults with premature ovarian insufficiency (POI). |
| 08:55 | FC6.2 | Next generation sequencing of the androgen receptor (AR) gene in patients with androgen insensitivity syndrome (AIS) and controls |
| 09:05 | FC6.3 | LRH-1 rescues SF-1 deficiency for steroidogenesis in vitro but cannot explain the broad phenotype of SF-1 deficiency in men |
| 09:15 | FC6.4 | FAMILIAL 46,XY COMPLETE FEMALE EXTERNAL SEX DEVELOPMENT AND PRIMARY AMENORRHEA ALONG WITH HIDDEN GONADAL TUMORS, SECONDARY TO A NOVEL p.MET64VAL SRY GENE MUTATION |
| 09:25 | FC6.5 | Serum levels of AMH reflect ovarian morphology by MRI in 109 healthy peripubertal girls |
| 09:35 | FC6.6 | Effects of exposure to the endocrine disruptor di(n-butyl) phthalate on testicular dysgenesis and fetal germ cell development in the rat and human fetal testis. |
| 08:45-09:45 | | Free Communication 7 - Growth Promoting Therapies
Chair(s): Leo Dunkel (London, UK) & Fayza Darendelier (Istanbul, Turkey)
Liffey A
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| 08:45 | FC7.1 | Genetic markers of insulin resistance are associated with growth hormone response in short SGA children – the North European SGA Study (NESGAS) |
| 08:55 | FC7.2 | The rs1024531 GRB10 promoter polymorphism is associated with response to growth hormone (GH) therapy in patients with GH deficiency (GHD): validation by in vitro functional analysis |
| 09:05 | FC7.3 | Gene expression networks associated with changes in serum markers of metabolism and growth in growth hormone (GH)-treated children with GH deficiency (GHD) |
| 09:15 | FC7.4 | A decade of clinical experience in a Swedish university centre using prediction models to optimize growth hormone (GH) treatment in prepubertal children |
| 09:25 | FC7.5 | Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome – A High Resolution Peripheral Quantitative Computed Tomography Study |
| 09:35 | FC7.6 | Topicon™ ThermoMatrix™-Mediated Passive Transdermal Delivery of Human Growth Hormone (hGH) Across EpidermFT™ Full-Thickness Human Skin Equivalent (HSE): Towards an Extended-Wear hGH Patch |
| 08:45-09:45 | | Free Communication 8 - Fat Metabolism
Chair(s): Abei Lopez Bermejo (Girona, Spain) & Saraf Farooqi (Cambridge, UK)
Wicklow Hall 1
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| 08:45 | FC8.1 | Activation of the ER stress response in cultured human umbilical vein endothelial cells (HUVECs) by plasma obtained from prepubertal obese children. |
| 08:55 | FC8.2 | MicroRNA-152 promotes hepatic steatosis by suppressing the Wnt signaling pathway |
| 09:05 | FC8.3 | Identification of death ligand TRAIL (TNF-related apoptosis-inducing ligand) as a potent mitogen in human preadipocytes |
| 09:15 | FC8.4 | CREB-REGULATED TRANSCRIPTION COACTIVATOR 3 (CRTC3): A NEW ADIPOKINE RELATED TO CHILDHOOD OBESITY |
| 09:25 | FC8.5 | Putative gain-of-function in rats carrying the Ghsr Q343X mutation |
| 09:35 | FC8.6 | A Novel Missense Variant in the Insulin Receptor Gene in 3 unrelated Irish families with severe Insulin Resistance Syndrome - Evidence for an Irish Founder Effect. |
| 08:45-09:45 | | Free Communication 9 - Beta Calls
Chair(s): Renata Lorini (Genova, Italy) & Carlo Acerini (Cambridge, UK)
Liffey Hall 2
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| 08:45 | FC9.1 | Inappropriately High Rates of Cell Proliferation in Diffuse Congenital Hyperinsulinism are Linked to Nuclear Expression of CDK6 |
| 08:55 | FC9.2 | Characterising the immunohistochemical expression of dipeptidyl peptidase-4 in pancreatic tissue from patients with diffuse and focal congential hyperinsulinism. |
| 09:05 | FC9.3 | In search for new monogenic diabetes genes: PCBD1 |
| 09:15 | FC9.4 | Clinical characteristics and molecular genetics analysis of 20 patients with neonatal diabetes mellitus from a single centre of the South-Eastern region of Turkey |
| 09:25 | FC9.5 | TRANSIENT NEONATAL DIABETES IN ADULTHOOD: METABOLIC AND NEURODEVELOPMENTAL OUTCOMES |
| 09:35 | FC9.6 | Sulfonylurea therapy corrects hypotonia, attention deficits, improves complex neuropsychological functions and motricity in patients with neonatal diabetes secondary to mutation in potassium channel subunits, through a central nervous system effect. |
| 08:45-09:45 | | New Perspectives 2
Chair(s): Tim O'Brien (Galway, Ireland) & José C. Moreno (Madrid, Spain)
Regenerative Endocrinology
Liffey B
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| 08:45 | NP2.1 | Pancreatic Beta Cell Development: from rodent to human |
| 09:15 | NP2.2 | Formation of a Thyroid Gland from Embryonic Stem Cells |
| 08:45-09:45 | | Free Communications - Late Breaking
Chair(s): Irene Netchine (Paris, France) & Susan O'Connell (Cork, Ireland)
Liffey Hall 1
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| 08:45 | FC-LB-1 | Top Line Results of Once-Weekly, CTP-Modified Human Growth Hormone (MOD-4023): Phase 2 Dose Finding Study in Children with Growth Hormone Deficiency (GHD) |
| 08:55 | FC-LB-2 | Sonic Hedgehog is required for cell specification of Rathke’s pouch progenitors during normal development and is over-expressed in adamantinomatous craniopharyngioma |
| 09:05 | FC-LB-3 | Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche |
| 09:15 | FC-LB-4 | Does Severity of Hypothyroidism at Birth Contribute to Abnormal Cortical Development among Children with Congenital Hypothyroidism (CH)? |
| 09:25 | FC-LB-5 | CB2 polymorphism could modulate the relationship between childhood obesity and age at menarche |
| 09:35 | FC-LB-6 | Global Consensus Recommendations on Prevention and Management of Nutritional Rickets |
| 10:15-10:45 | | Plenary Session 5
Chair(s): Jan Lebl (Prague, Czech Republic) & Reiko Horikawa (Tokyo, Japan)
Auditorium
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| 10:15 | PL5 | Obesity: Novel Treatments and the Imperative for Prevention |
| 10:45-11:45 | | ESPE Award Session and Activities 2
Auditorium
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| 12:00-13:00 | | Free Communication 10 - Programming & Early
Chair(s): Ken Ong (Cambridge, UK) & Colm Costigan (Crumlin, Ireland)
Liffey Hall 1
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| 12:00 | FC10.1 | A role for Delta-like homologue 1 (DLK1) in a secretory placental population and implications for foetal growth |
| 12:10 | FC10.2 | STK11 EXPRESSION IN ADIPOSE TISSUE FOLLOWING FETAL GROWTH RESTRICTION: RELATION TO CATCH-UP GROWTH AND VISCERAL FAT MASS. |
| 12:20 | FC10.3 | Genetic and epigenetic defects at the GNAS locus lead to opposite patterns of fetal and postnatal growth |
| 12:30 | FC10.4 | Influence of newborn and maternal factors on neonatal body composition |
| 12:40 | FC10.5 | Contrasting associations of maternal smoking and alcohol intake in late pregnancy and offspring body composition in childhood |
| 12:50 | FC10.6 | The PremAldo Study: Impaired Aldosterone Signaling Worsens Renal Sodium Loss in Preterm Infants |
| 12:00-13:00 | | Free Communication 11 - Pituitary
Chair(s): Ivo Arnhold (Sao Paulo, Brazil) & Juliane Leger (Paris, France)
Liffey A
|
| 12:00 | FC11.1 | ABNORMAL SONIC HEDGEHOG SIGNALING IN ADAMANTINOMATOUS CRANIOPHARYNGIOMAS AND ITS ASSOCIATION WITH CTNNB1/BETA-CATENIN MUTATIONS |
| 12:10 | FC11.2 | Novel SOX2 mutation: identification of new molecular mechanisms of SOX2 action and interactions. |
| 12:20 | FC11.3 | Early-Onset Central Diabetes Insipidus is associated with De novo Arginine Vasopressin-Neurophysin II or Wolfram Syndrome 1 gene mutations |
| 12:30 | FC11.4 | Management of hyperhydration in a child with Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) using a selective vasopresin receptor agonist. |
| 12:40 | FC11.5 | ENDOCRINE FEATURES OF A LARGE COHORT OF CHILDREN WITH SEPTO-OPTIC DYSPLASIA AND CONGENITAL MULTIPLE PITUITARY HORMONAL DEFICIENCIES |
| 12:50 | FC11.6 | Clinical and neuroradiological characteristics in children and adolescents with Septo-Optic Dysplasia, Multiple Pituitary Hormone Deficiencies and Optic Nerve Hypoplasia: Experience from a single tertiary centre. |
| 12:00-13:00 | | Free Communication 12 - Obesity
Chair(s): Jean-Pierre Chanoine (Vancouver, Canada) & Judith Meehan (Dublin, Ireland)
Wicklow Hall 2
|
| 12:00 | FC12.1 | High-fat diet rapidly triggers circadian de-synchronization of clock genes, neuropeptides and inflammation mediators in the hypothalamus of C57BL mice |
| 12:10 | FC12.2 | Obesity in childhood and adolescence is associated with shorter leucocyte telomere length |
| 12:20 | FC12.3 | Increased resting energy expenditure in girls with Turner syndrome |
| 12:30 | FC12.4 | Pediatric reference values for insulin from oGTT and prevalence of hyperinsulinemia in obese children |
| 12:40 | FC12.5 | Low Circulating Levels of DKK-1 Protein in Obese Children Indicate Suppression of Canonical Wnt Signaling |
| 12:50 | FC12.6 | Resveratrol inhibits inflammation-induced production of cytokines in human adipocytes |
| 12:00-13:00 | | Free Communication 13 - Thyroid
Chair(s): Marek Niedziela (Poznan, Poland) & Heiko Krude (Berlin, Germany)
Liffey Hall 2
|
| 12:00 | FC13.1 | Massive sequencing of thyroidal genes reveals unexpected polygenic defects in dyshormonogenic hypothyroidism. |
| 12:10 | FC13.2 | Thyroid agenesis and severe thyroid hypoplasia caused by a new inactivating TSH receptor mutation Ala579Val |
| 12:20 | FC13.3 | Overexpression of supressor tumoral PTEN, but not DREAM, was detected in multinodular goiter in humans. |
| 12:30 | FC13.4 | The prevalence of congenital malformations in infants with TSH elevation on newborn screening – the importance of distinguishing between true and transient congenital hypothyroidism |
| 12:40 | FC13.5 | THE ULTRASTRUCTURAL CHANGES IN THYROID CELLS IN THE COURSE OF DAMAGE IN HASHIMOTO’S THYROIDITIS |
| 12:50 | FC13.6 | ABNORMAL THYROID HORMONE METABOLISM IN PATIENTS WITH THRA MUTATIONS DUE TO IMPAIRED EXPRESSION OF THE TYPE 3 DEIODINASE |
| 12:00-13:00 | | Free Communication 14 - Puberty
Chair(s): Margaret Zacharin (Melbourne, Austrailia) & Clodagh O'Gorman (Limerick, Ireland)
Liffey B
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| 12:00 | FC14.1 | Brain structure and function in gender dysphoric adolescents |
| 12:10 | FC14.2 | Infancy growth rate predicts timing of puberty both in girls and boys |
| 12:20 | FC14.3 | Novel genetic variants in a cohort of paediatric and adolescent patients with Hypogonadotrophic Hypogonadism and Kallmann syndrome |
| 12:30 | FC14.4 | Development of pubertal gynaecomastia - A longitudinal cohort study |
| 12:40 | FC14.5 | Fertility of women treated during childhood for precocious puberty with triptorelin: PREFER retrospective study |
| 12:50 | FC14.6 | QUALITY OF LIFE IN PATIENTS WITH CONGENITAL HYPOGONADOTROPIC HYPOGONADISM (CHH) |
| 12:00-13:00 | | Yearbook of Paediatric Endocrinology
Chair(s): Wieland Kiess (Leipzig, Germany) & Ze'ev Hochberg (Haifa, Israel)
Auditorium
|
| 13:00-13:30 | | Lunch
Visit to the Posters and Exhibition
|
| 15:00-16:30 | | Symposium 8 - Novel Therapies in Paediatric Endocrinology
Chair(s): Nils Krone (Birmingham, UK) & Alan Rogol (Virginia, USA)
Liffey B
|
| 15:00 | S8.1 | Hyperinsulinaemia |
| 15:30 | S8.2 | Treatment of Hypophosphatasia |
| 16:00 | S8.3 | Congenital Adrenal Hyperplasia |
| 15:00-16:30 | | Symposium 9 - Novel Insights into Pituitary Development and Function
Chair(s): Roland Pfaeffle (Leipzig, Germany) & Ron Rosenfeld (USA)
Wicklow Hall 2
|
| 15:00 | S9.1 | Paracrine Regulation in the Pituitary |
| 15:30 | S9.2 | Sox2+ve cells in the adult murine pituitary are stem cells with tumour-inducing potential |
| 16:00 | S9.3 | Pax7 dictates alternate pituitary cell fates during development |
| 15:00-16:30 | | Symposium 10 - Childhood Obesity: Challenges in Management
Chair(s): Phil Zeitler (Colorado, USA) & Ewa Malecka-Tendera (Katowice, Poland)
Liffey A
|
| 15:00 | S10.1 | The Metabolically Healthy Obese Child |
| 15:30 | S10.2 | Childhood and Adolescent Obesity - Can Treatment Response be Predicted? |
| 16:00 | S10.3 | Natural Course of Impaired Glucose Tolerance in Obese Children |
| 15:00-16:00 | | Meet the Expert Parallel Sessions
|
| 15:00 - 16:00 | MTE6.2 | Assessment of Thyroid Nodules |
| 15:00 - 16:00 | MTE7.2 | Clinical Management of Cystic Firbrosis Related Diabetes (CRFD) in Childhood |
| 15:00 - 16:00 | MTE8.2 | Evaluation and the Management of Tall Stature |
| 16:30-17:00 | | Coffee Break
|
| 17:00-17:30 | | Plenary 6
Chair(s): Mehul Dattani (London, UK) & Cheri Deal (Montréal, Canada)
Auditorium
|
| 17:00 | PL6 | Genetics of Obesity |
| 17:30-17:45 | | President Poster Award
Auditorium
|
| 17:45-18:00 | | Closing Ceremony
Auditorium
|
| 19:00- | | ESPE Evening
|